Tfe3 MGI Mouse Gene Detail - MGI:98511 - transcription factor E3

Symbol

Tfe3
Name

transcription factor E3
Synonyms

bHLHe33, F830016E06Rik, Tcfe3, Tfe-3, Tfe3

Feature Type

protein coding gene
IDs

MGI:98511
NCBI Gene: 209446
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

ChrX:7628799-7641441 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 3.50 cM, cytoband A2
Mapping Data

18 experiments

SNPs within 2kb

284 from dbSNP Build 142
Strain Annotations

18
PCR

2
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98511	protein coding gene	ChrX:7628769-7641441 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035523	protein coding gene	ChrX:2380145-2392787 (+)
A/J	MGP_AJ_G0035501	protein coding gene	ChrX:2341917-2354744 (+)
AKR/J	MGP_AKRJ_G0035433	protein coding gene	ChrX:2461296-2473935 (+)
BALB/cJ	MGP_BALBcJ_G0035497	protein coding gene	ChrX:2364749-2378191 (+)
C3H/HeJ	MGP_C3HHeJ_G0035205	protein coding gene	ChrX:2430168-2442809 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0036021	protein coding gene	ChrX:2466038-2478678 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032897	protein coding gene	ChrX:1907207-1919930 (+)
CAST/EiJ	MGP_CASTEiJ_G0034506	protein coding gene	ChrX:2319395-2331946 (+)
CBA/J	MGP_CBAJ_G0035175	protein coding gene	ChrX:2587208-2599849 (+)
DBA/2J	MGP_DBA2J_G0035332	protein coding gene	ChrX:2366652-2379194 (+)
FVB/NJ	MGP_FVBNJ_G0035279	protein coding gene	ChrX:2329002-2341644 (+)
LP/J	MGP_LPJ_G0035410	protein coding gene	ChrX:2401184-2413826 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035319	protein coding gene	ChrX:2560316-2572956 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036039	protein coding gene	ChrX:2366845-2379489 (+)
PWK/PhJ	MGP_PWKPhJ_G0034207	protein coding gene	ChrX:2298417-2311079 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034045	protein coding gene	ChrX:2345374-2358015 (+)
WSB/EiJ	MGP_WSBEiJ_G0034629	protein coding gene	ChrX:2374883-2387523 (+)

Human Ortholog

TFE3, transcription factor binding to IGHM enhancer 3

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TFE3, transcription factor binding to IGHM enhancer 3
Synonyms

bHLHe33, MRXSPF, RCCP2, RCCX1, TFEA
Links

HGNC:11752

NCBI Gene ID: 7030

neXtProt AC: NX_P19532

UniProt: P19532
Chr Location

Xp11.23; chrX:49028726-49043410 (-) GRCh38

MGI Vertebrate Homology

Tfe3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: TFE3
Gene Tree

Tfe3

Diseases

1 with human TFE3 associations

				Human Disease	Mouse Models
				renal cell carcinoma IDs renal cell carcinoma DOID:4450 EFO:0000681 MESH:D002292 NCI:C9385 OMIM:300854 ORDO:217071 UMLS_CUI:C0007134

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
9 phenotypes from multigenic genotypes
27 phenotype references

All Mutations and Alleles

45
Endonuclease-mediated

3
Gene trapped

38
Targeted

4
Find Mice (IMSR)

23 strains or lines available

Mice homozygous for a knock-out allele are viable and fertile, normally pigmented, have normal eyes and mast cells, and show no evidence of osteopetrosis.

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All GO Annotations

38
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

971
Tissues

237
cDNA Data

103
Literature Summary

12

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tfe3

ZFIN tfe3a, tfe3b

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All Sequences

114
RefSeq

25
UniProt

8
CCDS

CCDS52984.1, CCDS52985.1, CCDS72332.1, CCDS72333.1

Ensembl

ENSMUSG00000000134 (Evidence)
NCBI Gene

209446

			Length	Strain/Species	Flank
genomic	ENSMUSG00000000134	Ensembl Gene Model \| MGI Sequence Detail	12643	C57BL/6J	± kb
transcript	ENSMUST00000077680	Ensembl \| MGI Sequence Detail	3277	Not Applicable
polypeptide	ENSMUSP00000076864	Ensembl \| MGI Sequence Detail	572	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000016271 transcription factor E3

(term hierarchy)
InterPro Domains

IPR036638 Helix-loop-helix DNA-binding domain superfamily

IPR021802 MiT/TFE transcription factors, C-terminal

IPR031867 MiT/TFE transcription factors, N-terminal

IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain

IPR024100 Transcription factor E3, bHLHzip domain
GlyGen

Q64092 4 sites, 1 O-linked glycan (4 sites)

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All nucleic 115

Genomic 5

cDNA 103

Primer pair 5

Other 2

Microarray probesets 4

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MGD-MRK-14763, MGD-MRK-15044, MGD-MRK-15045, MGI:2147926

Summaries

All 105

Developmental Gene Expression 12

Gene Ontology 12

Phenotypes 27
Earliest

J:29571 Roman C, et al., A dominant negative form of transcription activator mTFE3 created by differential splicing. Science. 1991 Oct 4;254(5028):94-7
Latest

J:355468 Patel AA, et al., TFEB/3 Govern Repair Schwann Cell Generation and Function Following Peripheral Nerve Injury. J Neurosci. 2024 Aug 28;44(35)

TSS for Tfe3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr160423	ChrX:7628787-7628801 (+)	-5 bp
Tssr160424	ChrX:7628891-7628928 (+)	111 bp
Tssr160425	ChrX:7628942-7628968 (+)	156 bp
Tssr160426	ChrX:7629028-7629048 (+)	239 bp
Tssr160427	ChrX:7629051-7629076 (+)	265 bp
Tssr160428	ChrX:7629121-7629137 (+)	330 bp
Tssr160429	ChrX:7629142-7629153 (+)	349 bp
Tssr160430	ChrX:7630190-7630204 (+)	1,398 bp
Tssr160431	ChrX:7630489-7630502 (+)	1,697 bp
Tssr160432	ChrX:7630515-7630526 (+)	1,722 bp
Tssr160433	ChrX:7630549-7630560 (+)	1,756 bp
Tssr160434	ChrX:7630562-7630590 (+)	1,777 bp
Tssr160435	ChrX:7630637-7630654 (+)	1,847 bp
Tssr160436	ChrX:7633763-7633796 (+)	4,981 bp
Tssr160437	ChrX:7641008-7641020 (+)	12,215 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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