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Maoa Gene Detail
Summary
  • Symbol
    Maoa
  • Name
    monoamine oxidase A
  • Synonyms
    1110061B18Rik, MAO-A, MGC:27811
  • Feature Type
    protein coding gene
  • IDs
    MGI:96915
    NCBI Gene: 17161
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:16485937-16554051 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 11.78 cM, cytoband A2
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1271 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96915
 protein coding gene ChrX:16485937-16554057 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035579
 protein coding gene ChrX:11476000-11544105 (+)
A/J MGP_AJ_G0035556
 protein coding gene ChrX:11569356-11631915 (+)
AKR/J MGP_AKRJ_G0035488
 protein coding gene ChrX:11930962-12000876 (+)
BALB/cJ MGP_BALBcJ_G0035549
 protein coding gene ChrX:11384779-11451191 (+)
C3H/HeJ MGP_C3HHeJ_G0035266
 protein coding gene ChrX:11612076-11676206 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036084
 protein coding gene ChrX:11772396-11841269 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032949
 protein coding gene ChrX:10123062-10189119 (+)
CAST/EiJ MGP_CASTEiJ_G0034558
 protein coding gene ChrX:11166133-11233674 (+)
CBA/J MGP_CBAJ_G0035235
 protein coding gene ChrX:12304619-12382358 (+)
DBA/2J MGP_DBA2J_G0035387
 protein coding gene ChrX:11419849-11487351 (+)
FVB/NJ MGP_FVBNJ_G0035334
 protein coding gene ChrX:11279735-11349747 (+)
LP/J MGP_LPJ_G0035469
 protein coding gene ChrX:11763604-11831247 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035378
 protein coding gene ChrX:12399899-12486910 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036091
 protein coding gene ChrX:11404553-11468828 (+)
PWK/PhJ MGP_PWKPhJ_G0034259
 protein coding gene ChrX:10744398-10807586 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034098
 protein coding gene ChrX:11388088-11460322 (+)
WSB/EiJ MGP_WSBEiJ_G0034693
 protein coding gene ChrX:11366270-11443628 (+)



Homology
more
  • Human Ortholog
    MAOA, monoamine oxidase A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAOA, monoamine oxidase A
  • Synonyms
    BRNRS, MAO-A
  • Links
    NCBI Gene ID: 4128
    neXtProt AC: NX_P21397
    UniProt: P21397

  • Chr Location
    Xp11.3; chrX:43654907-43746817 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Maoa mouse models; 5 with human MAOA associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 3 alleles in 3 genetic backgrounds
    6 phenotypes from multigenic genotypes
    63 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show reduced LV systolic pressure and resistance to induced cardiac stress. Males hemizygous for a spontaneous allele show intermale aggression and hypoactivity. Hemizygotes for a transgenic gene disruption show altered behavior and adrenocortical response to stress.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1101
  • Tissues
    167
  • cDNA Data
    25
  • Literature Summary
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17161 NCBI Gene Model | MGI Sequence Detail 68115 C57BL/6J ±  kb
    transcript NM_173740 RefSeq | MGI Sequence Detail 4161 ZRU/MplStud  
    polypeptide Q64133 UniProt | EBI | MGI Sequence Detail 526 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 32
      Genomic 1
      cDNA 26
      Primer pair 4
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-12111, MGI:1916081, MGI:2147818
    References
    more
    • Summaries
      All 134
      Developmental Gene Expression 19
      Diseases 2
      Gene Ontology 13
      Phenotypes 63
    • Earliest
      J:10089 Derry JM, et al., Localization of monoamine oxidase A and B genes on the mouse X chromosome. Nucleic Acids Res. 1989 Oct 25;17(20):8403
    • Latest
      J:330340 Lapierre JA, et al., Deletion of monoamine oxidase A in a prostate cancer model enhances anti-tumor immunity through reduced immune suppression. Biochem Biophys Res Commun. 2022 Oct 6;634:100-107
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory