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Cdk6 Gene Detail
Summary
  • Symbol
    Cdk6
  • Name
    cyclin dependent kinase 6
  • Synonyms
    Crk2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277162
    NCBI Gene: 12571
  • Alliance
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:3391485-3581008 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 5, 2.04 cM, cytoband A2-A3
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4116 from dbSNP Build 142
  • Strain Annotations
    17
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1277162
protein coding gene Chr5:3391004-3581008 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029255
protein coding gene Chr5:182886-336759 (+)
A/J MGP_AJ_G0029220
protein coding gene Chr5:7155-218113 (+)
AKR/J MGP_AKRJ_G0029168
protein coding gene Chr5:46089-216269 (+)
BALB/cJ MGP_BALBcJ_G0029236
protein coding gene Chr5:189396-450738 (+)
C3H/HeJ MGP_C3HHeJ_G0028957
protein coding gene Chr5:192060-386407 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029686
protein coding gene Chr5:353162-591119 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026928
protein coding gene Chr5:14125-250652 (+)
CAST/EiJ MGP_CASTEiJ_G0028369
protein coding gene Chr5:154810-392706 (+)
CBA/J MGP_CBAJ_G0028919
protein coding gene Chr5:238189-483768 (+)
DBA/2J MGP_DBA2J_G0029068
protein coding gene Chr5:120910-205937 (+)
FVB/NJ MGP_FVBNJ_G0029031
protein coding gene Chr5:117397-280943 (+)
LP/J MGP_LPJ_G0029158
protein coding gene Chr5:88827-375302 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029058
protein coding gene Chr5:76497-293503 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029717
protein coding gene Chr5:117173-341050 (+)
PWK/PhJ MGP_PWKPhJ_G0028090
protein coding gene Chr5:191575-351979 (+)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0028449
protein coding gene Chr5:217052-365843 (+)



Homology
more
  • Human Ortholog
    CDK6, cyclin dependent kinase 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CDK6, cyclin dependent kinase 6
  • Synonyms
    MCPH12, PLSTIRE
  • Links
    NCBI Gene ID: 1021
    neXtProt AC: NX_Q00534
    UniProt: Q00534

  • Chr Location
    7q21.2; chr7:92604921-92836573 (-)  GRCh38

Human Diseases
more
  • Diseases
    5 with human CDK6 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    48 phenotypes from 7 alleles in 5 genetic backgrounds
    29 phenotypes from multigenic genotypes
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display hematopoietic abnormalities affecting spleen and thymus size. Female body weight and fertility are also reduced.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040274 Ensembl Gene Model | MGI Sequence Detail 189524 C57BL/6J ±  kb
    transcript ENSMUST00000165117 Ensembl | MGI Sequence Detail 11525 Not Applicable  
    polypeptide ENSMUSP00000126024 Ensembl | MGI Sequence Detail 326 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      Genomic 1
      cDNA 22
      Primer pair 6
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-2146, MGI:2140921, MGI:88503
    References
    more
    • Summaries
      All 147
      Developmental Gene Expression 46
      Diseases 1
      Gene Ontology 18
      Phenotypes 39
    • Earliest
      J:19713 Meyerson M, et al., A family of human cdc2-related protein kinases. EMBO J. 1992 Aug;11(8):2909-17
    • Latest
      J:354227 Barao S, et al., Conserved transcriptional regulation by BRN1 and BRN2 in neocortical progenitors drives mammalian neural specification and neocortical expansion. Nat Commun. 2024 Sep 14;15(1):8043

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    10/22/2024
    MGI 6.24
    The Jackson Laboratory