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Cd34 Gene Detail
Summary
  • Symbol
    Cd34
  • Name
    CD34 antigen
  • Feature Type
    protein coding gene
  • IDs
    MGI:88329
    NCBI Gene: 12490
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:194621239-194643587 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 98.38 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    357 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88329
 protein coding gene Chr1:194621127-194643587 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016966
 protein coding gene Chr1:202110853-202134885 (+)
A/J MGP_AJ_G0016945
 protein coding gene Chr1:193815426-193837998 (+)
AKR/J MGP_AKRJ_G0016910
 protein coding gene Chr1:199546973-199569428 (+)
BALB/cJ MGP_BALBcJ_G0016903
 protein coding gene Chr1:194511627-194534105 (+)
C3H/HeJ MGP_C3HHeJ_G0016727
 protein coding gene Chr1:200441310-200463810 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017366
 protein coding gene Chr1:208485161-208508627 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015073
 protein coding gene Chr1:185219792-185242779 (+)
CAST/EiJ MGP_CASTEiJ_G0016310
 protein coding gene Chr1:200006257-200029534 (+)
CBA/J MGP_CBAJ_G0016701
 protein coding gene Chr1:216174116-216196949 (+)
DBA/2J MGP_DBA2J_G0016807
 protein coding gene Chr1:192530840-192553255 (+)
FVB/NJ MGP_FVBNJ_G0016803
 protein coding gene Chr1:190623261-190646769 (+)
LP/J MGP_LPJ_G0016882
 protein coding gene Chr1:203262511-203286627 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016835
 protein coding gene Chr1:222825087-222849438 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017403
 protein coding gene Chr1:199403220-199426239 (+)
PWK/PhJ MGP_PWKPhJ_G0016097
 protein coding gene Chr1:191847762-191870334 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015873
 protein coding gene Chr1:198448292-198470751 (+)
WSB/EiJ MGP_WSBEiJ_G0016372
 protein coding gene Chr1:199680012-199702347 (+)



Homology
more
  • Human Ortholog
    CD34, CD34 molecule
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CD34, CD34 molecule
  • Links
    NCBI Gene ID: 947
    neXtProt AC: NX_P28906
    UniProt: P28906

  • Chr Location
    1q32.2; chr1:207880972-207911402 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show decreased splenocyte number and hematopoietic defects. Homozygotes for another null allele show reduced eosinophil accumulation after allergen exposure, impaired TPA-induced hair follicle stem cell activation and reduced incidence of chemically-induced skin tumors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    62
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1513
  • Tissues
    415
  • cDNA Data
    124
  • Literature Summary
    200
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12490 NCBI Gene Model | MGI Sequence Detail 22349 C57BL/6J ±  kb
    transcript NM_001111059 RefSeq | MGI Sequence Detail 2498 ZRU/MplStud  
    polypeptide Q64314 UniProt | EBI | MGI Sequence Detail 382 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 136
      Genomic 4
      cDNA 126
      Primer pair 3
      Other 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1849, MGI:2138487
    References
    more
    • Summaries
      All 275
      Developmental Gene Expression 200
      Gene Ontology 17
      Phenotypes 23
    • Earliest
      J:2996 Howell SM, et al., Localisation of the gene coding for the haemopoietic stem cell antigen CD34 to chromosome 1q32. Hum Genet. 1991 Sep;87(5):625-7
    • Latest
      J:348104 Lan W, et al., A subset of megakaryocytes regulates development of hematopoietic stem cell precursors. EMBO J. 2024 May;43(9):1722-1739
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory