Npdc1 Gene Detail

Summary

• Symbol
  Npdc1
• Name
  neural proliferation, differentiation and control 1
• Synonyms
  NPDC-1

• Feature Type
  protein coding gene
• IDs
  MGI:1099802
  NCBI Gene: 18146
• Alliance
  gene page
• Transcription Start Sites
  2 TSS

Location &
Maps

• Sequence Map
  Chr2:25293067-25299504 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 2, 17.23 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  206 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1099802	protein coding gene	Chr2:25289363-25299506 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025444	protein coding gene	Chr2:23283676-23295328 (+)
A/J	MGP_AJ_G0025421	protein coding gene	Chr2:22382853-22393135 (+)
AKR/J	MGP_AKRJ_G0025391	protein coding gene	Chr2:23129836-23140052 (+)
BALB/cJ	MGP_BALBcJ_G0025417	protein coding gene	Chr2:22496015-22506563 (+)
C3H/HeJ	MGP_C3HHeJ_G0025178	protein coding gene	Chr2:23067432-23079495 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025861	protein coding gene	Chr2:24032919-24044228 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023272	protein coding gene	Chr2:21293934-21303980 (+)
CAST/EiJ	MGP_CASTEiJ_G0024641	protein coding gene	Chr2:22945273-22956582 (+)
CBA/J	MGP_CBAJ_G0025156	protein coding gene	Chr2:24861093-24873561 (+)
DBA/2J	MGP_DBA2J_G0025289	protein coding gene	Chr2:22222263-22232403 (+)
FVB/NJ	MGP_FVBNJ_G0025251	protein coding gene	Chr2:21964935-21976007 (+)
LP/J	MGP_LPJ_G0025375	protein coding gene	Chr2:23227222-23239378 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025282	protein coding gene	Chr2:25053321-25065396 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025920	protein coding gene	Chr2:23083313-23095873 (+)
PWK/PhJ	MGP_PWKPhJ_G0024389	protein coding gene	Chr2:22043283-22054937 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024189	protein coding gene	Chr2:23226808-23237957 (+)
WSB/EiJ	MGP_WSBEiJ_G0024710	protein coding gene	Chr2:23157343-23169840 (+)

Homology

• Human Ortholog
  NPDC1, neural proliferation, differentiation and control 1

• Vertebrate Orthologs
  4

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  NPDC1, neural proliferation, differentiation and control 1
  
• Synonyms
  CAB, CAB-, CAB-1, CAB1, NPDC-1
• Links
  HGNC:7899

  NCBI Gene ID: 56654

  neXtProt AC: NX_Q9NQX5

  UniProt: Q9NQX5

  
  
• Chr Location
  9q34.3; chr9:137039463-137046179 (-)  GRCh38

---

• MGI Vertebrate Homology
  Npdc1 stringent orthology
  1 human;1 mouse;1 rat;2 zebrafish
  
• HCOP
  vertebrate homology predictions: NPDC1
• Gene Tree
  Npdc1
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 1 allele in 1 genetic background
  3 phenotype references
  

• All Mutations and Alleles
  2
• Endonuclease-mediated
  1
• Targeted
  1
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  31 strains or lines available

Homozygous null mice display no obvious abnormalities in viability, fertility, behavior, or brain morphology.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  1
• GO References
  1

Expression

• Assay Results
  809
• Tissues
  31
• cDNA Data
  150
• Literature Summary
  6

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase npdc1, npdc1.2
  ZFIN npdc1a

Sequences &
Gene Models

• All Sequences
  63
• RefSeq
  6
• UniProt
  6
• CCDS
  CCDS15771.1

• Ensembl
  ENSMUSG00000015094 (Evidence)
• NCBI Gene
  18146

Representative Sequences			Length	Strain/Species
genomic	18146	NCBI Gene Model | MGI Sequence Detail	6438	C57BL/6J
transcript	NM_001420469	RefSeq | MGI Sequence Detail	1535	C57BL/6
polypeptide	Q64322	UniProt | EBI | MGI Sequence Detail	332	Not Applicable

Protein
Information

• UniProt
  6 Sequences
• Protein Ontology
  PR:000011359 neural proliferation differentiation and control protein 1
  (term hierarchy)
• InterPro Domains
  IPR009635 Neural proliferation differentiation control-1
• GlyGen
  Q64322 2 sites, 1 O-linked glycan (2 sites)

Molecular
Reagents

• All nucleic 152

  cDNA 151

  Primer pair 1

  
  

  Microarray probesets 3

Other
Accession IDs

MGI:2138881

References

• Summaries
  All 28

  Developmental Gene Expression 6

  Gene Ontology 1

  Phenotypes 3
• Earliest
  J:23322 Galiana E, et al., Identification of a neural-specific cDNA, NPDC-1, able to down-regulate cell proliferation and to suppress transformation. Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1560-4
• Latest
  J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034

TSS for Npdc1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr16712	Chr2:25293056-25293127 (+)	25 bp
Tssr16713	Chr2:25293140-25293212 (+)	109 bp