About   Help   FAQ
Piga Gene Detail
Summary
  • Symbol
    Piga
  • Name
    phosphatidylinositol glycan anchor biosynthesis, class A
  • Synonyms
    phosphatidylinositolglycan class A, Pig-a
  • Feature Type
    protein coding gene
  • IDs
    MGI:99461
    NCBI Gene: 18700
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:163202814-163216912 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 76.49 cM, cytoband F3-F4
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    343 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99461
 protein coding gene ChrX:163202783-163216912 (+)
129S1/SvImJ MGP_129S1SvImJ_G0036256
 protein coding gene ChrX:162517481-162531600 (+)
A/J MGP_AJ_G0036226
 protein coding gene ChrX:161681555-161696058 (+)
AKR/J MGP_AKRJ_G0036154
 protein coding gene ChrX:166875639-166889758 (+)
BALB/cJ MGP_BALBcJ_G0036219
 protein coding gene ChrX:159683030-159697149 (+)
C3H/HeJ MGP_C3HHeJ_G0035926
 protein coding gene ChrX:162853340-162867451 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036742
 protein coding gene ChrX:167261720-167275843 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033562
 protein coding gene ChrX:152715850-152730020 (+)
CAST/EiJ MGP_CASTEiJ_G0035214
 protein coding gene ChrX:141833193-141847337 (+)
CBA/J MGP_CBAJ_G0035900
 protein coding gene ChrX:172128950-172143069 (+)
DBA/2J MGP_DBA2J_G0036066
 protein coding gene ChrX:160554579-160568698 (+)
FVB/NJ MGP_FVBNJ_G0035998
 protein coding gene ChrX:159691865-159706009 (+)
LP/J MGP_LPJ_G0036151
 protein coding gene ChrX:163640629-163654748 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0036030
 protein coding gene ChrX:180793734-180807853 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036781
 protein coding gene ChrX:161995017-162009136 (+)
PWK/PhJ MGP_PWKPhJ_G0034912
 protein coding gene ChrX:138606357-138620243 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034733
 protein coding gene ChrX:142344872-142359002 (+)
WSB/EiJ MGP_WSBEiJ_G0035349
 protein coding gene ChrX:159959141-159973260 (+)



Homology
more
  • Human Ortholog
    PIGA, phosphatidylinositol glycan anchor biosynthesis class A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PIGA, phosphatidylinositol glycan anchor biosynthesis class A
  • Synonyms
    GPI3, MCAHS2, NEDEPH, PIG-A, PNH1
  • Links
    NCBI Gene ID: 5277
    neXtProt AC: NX_P37287
    UniProt: P37287

  • Chr Location
    Xp22.2; chrX:15319451-15335554 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Piga mouse models; 2 with human PIGA associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    43 phenotypes from 4 alleles in 7 genetic backgrounds
    1 images
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations produce lethal neural tube defects. Specific allele combinations are viable but oocytes are defective. Neural crest cell-specific KO leads to cleft lip and palate and craniofacial skeleton abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    809
  • Tissues
    100
  • cDNA Data
    13
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18700 NCBI Gene Model | MGI Sequence Detail 14099 C57BL/6J ±  kb
    transcript NM_011081 RefSeq | MGI Sequence Detail 3563 ZRU/MplStud  
    polypeptide Q64323 UniProt | EBI | MGI Sequence Detail 485 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      Genomic 9
      cDNA 16

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-16231, MGI:2147852
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 7
      Phenotypes 30
    • Earliest
      J:26642 Takeda J, et al., Deficiency of the GPI anchor caused by a somatic mutation of the PIG-A gene in paroxysmal nocturnal hemoglobinuria. Cell. 1993 May 21;73(4):703-11
    • Latest
      J:346523 Murakami Y, et al., AAV-based gene therapy ameliorated CNS-specific GPI defect in mouse models. Mol Ther Methods Clin Dev. 2024 Mar 14;32(1):101176
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory