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Cyp1b1 Gene Detail
Summary
  • Symbol
    Cyp1b1
  • Name
    cytochrome P450, family 1, subfamily b, polypeptide 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88590
    NCBI Gene: 13078
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:80014369-80022490 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 50.30 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    324 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88590
 protein coding gene Chr17:80008966-80022490 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024053
 protein coding gene Chr17:82576051-82584113 (-)
A/J MGP_AJ_G0024010
 protein coding gene Chr17:80041750-80049820 (-)
AKR/J MGP_AKRJ_G0023979
 protein coding gene Chr17:81262243-81270328 (-)
BALB/cJ MGP_BALBcJ_G0024012
 protein coding gene Chr17:79917951-79926025 (-)
C3H/HeJ MGP_C3HHeJ_G0023776
 protein coding gene Chr17:82169643-82177708 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024456
 protein coding gene Chr17:85588387-85596454 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021898
 protein coding gene Chr17:75427552-75435622 (-)
CAST/EiJ MGP_CASTEiJ_G0023256
 protein coding gene Chr17:82805482-82814976 (-)
CBA/J MGP_CBAJ_G0023750
 protein coding gene Chr17:89145414-89153498 (-)
DBA/2J MGP_DBA2J_G0023879
 protein coding gene Chr17:78562652-78570733 (-)
FVB/NJ MGP_FVBNJ_G0023845
 protein coding gene Chr17:78063237-78071297 (-)
LP/J MGP_LPJ_G0023962
 protein coding gene Chr17:83421542-83433882 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023873
 protein coding gene Chr17:89222421-89230498 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024501
 protein coding gene Chr17:81746286-81754357 (-)
PWK/PhJ MGP_PWKPhJ_G0023002
 protein coding gene Chr17:78064147-78072613 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022813
 protein coding gene Chr17:78523989-78532042 (-)
WSB/EiJ MGP_WSBEiJ_G0023323
 protein coding gene Chr17:82569789-82577858 (-)



Homology
more
  • Human Ortholog
    CYP1B1, cytochrome P450 family 1 subfamily B member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CYP1B1, cytochrome P450 family 1 subfamily B member 1
  • Synonyms
    ASGD6, CP1B, CYPIB1, GLC3A, P4501B1
  • Links
    NCBI Gene ID: 1545
    neXtProt AC: NX_Q16678
    UniProt: Q16678

  • Chr Location
    2p22.2; chr2:38066973-38109902 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Cyp1b1 mouse models; 7 with human CYP1B1 associations

Human Disease Mouse Models
      
IDs
 View 4 models
      
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 5 genetic backgrounds
    4 phenotypes from multigenic genotypes
    51 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are protected from the acute bone marrow cytotoxic and preleukemic effects of DMBA, show a decreased incidence of DMBA-induced lymphomas, and display background-sensitive ocular abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    90
  • GO References
    25
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    892
  • Tissues
    153
  • cDNA Data
    16
  • Literature Summary
    22
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13078 NCBI Gene Model | MGI Sequence Detail 8122 C57BL/6J ±  kb
    transcript NM_009994 RefSeq | MGI Sequence Detail 5161 C57BL/6  
    polypeptide Q64429 UniProt | EBI | MGI Sequence Detail 543 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      cDNA 19
      Primer pair 7
      Other 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-2304
    References
    more
    • Summaries
      All 127
      Developmental Gene Expression 22
      Diseases 1
      Gene Ontology 25
      Phenotypes 51
    • Earliest
      J:27812 Pottenger LH, et al., Purification and immunological characterization of a novel cytochrome P450 from C3H/10T1/2 cells. Arch Biochem Biophys. 1991 May 1;286(2):488-97
    • Latest
      J:344332 Stading R, et al., Prenatal exposure to polycyclic aromatic hydrocarbons (PAHs) augments neonatal hyperoxic lung injury: Role of cytochrome P450 (CYP)1A1, 1A2, and 1B1. Free Radic Biol Med. 2024 Feb 1;211:35-46
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory