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Ptprj Gene Detail
Summary
  • Symbol
    Ptprj
  • Name
    protein tyrosine phosphatase receptor type J
  • Synonyms
    Byp, CD148, DEP-1, RPTPJ, Scc-1, Scc1
  • Feature Type
    protein coding gene
  • IDs
    MGI:104574
    NCBI Gene: 19271
  • Alliance
    gene page
  • Transcription Start Sites
    48 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:90260098-90410939 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 50.19 cM, cytoband E1-2
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3284 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104574
 protein coding gene Chr2:90260098-90411102 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026129
 protein coding gene Chr2:91688910-91844464 (-)
A/J MGP_AJ_G0026090
 protein coding gene Chr2:88010866-88183127 (-)
AKR/J MGP_AKRJ_G0026071
 protein coding gene Chr2:90478301-90517648 (-)
BALB/cJ MGP_BALBcJ_G0026099
 protein coding gene Chr2:88183364-88238092 (-)
C3H/HeJ MGP_C3HHeJ_G0025850
 protein coding gene Chr2:90738561-90898012 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026550
 protein coding gene Chr2:94877574-95082234 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023940
 protein coding gene Chr2:84553092-84705534 (-)
CAST/EiJ MGP_CASTEiJ_G0015136
 protein coding gene Chr2:91262492-91296703 (-)
CBA/J MGP_CBAJ_G0025828
 protein coding gene Chr2:98147510-98323460 (-)
DBA/2J MGP_DBA2J_G0025964
 protein coding gene Chr2:87628141-87784148 (-)
FVB/NJ MGP_FVBNJ_G0025927
 protein coding gene Chr2:86713139-86882432 (-)
LP/J MGP_LPJ_G0026068
 protein coding gene Chr2:91855523-92039435 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025953
 protein coding gene Chr2:101226325-101391482 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026604
 protein coding gene Chr2:90517863-90667108 (-)
PWK/PhJ MGP_PWKPhJ_G0025050
 protein coding gene Chr2:87339414-87497446 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024851
 protein coding gene Chr2:90096157-90250559 (-)
WSB/EiJ MGP_WSBEiJ_G0025382
 protein coding gene Chr2:91095178-91253643 (-)



Homology
more
  • Human Ortholog
    PTPRJ, protein tyrosine phosphatase receptor type J
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PTPRJ, protein tyrosine phosphatase receptor type J
  • Synonyms
    CD148, DEP1, HPTP eta, HPTPeta, R-PTP-ETA, R-PTP-J, SCC1, THC10
  • Links
    NCBI Gene ID: 5795
    neXtProt AC: NX_Q12913
    UniProt: Q12913

  • Chr Location
    11p11.2; chr11:47980425-48170839 (+)  GRCh38
Human Diseases
more
  • Diseases
    4 with human PTPRJ associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    34 phenotypes from 5 alleles in 6 genetic backgrounds
    17 phenotypes from multigenic genotypes
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele die in utero displaying severe growth retardation and cardiovascular defects. Homozygotes for a second null allele are viable, fertile and healthy with no spontaneous tumor formation. Homozygotes for a third null allele show sterility and a block B cell development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    82
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    737
  • Tissues
    7
  • cDNA Data
    24
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025314 Ensembl Gene Model | MGI Sequence Detail 150842 C57BL/6J ±  kb
    transcript ENSMUST00000111495 Ensembl | MGI Sequence Detail 4197 Not Applicable  
    polypeptide ENSMUSP00000107121 Ensembl | MGI Sequence Detail 1299 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000001924 receptor-type tyrosine-protein phosphatase eta
      (term hierarchy)
    • EC
      3.1.3.48
    • InterPro Domains
      IPR003961 Fibronectin type III
      IPR036116 Fibronectin type III superfamily
      IPR013783 Immunoglobulin-like fold
      IPR016130 Protein-tyrosine phosphatase, active site
      IPR003595 Protein-tyrosine phosphatase, catalytic
      IPR029021 Protein-tyrosine phosphatase-like
      IPR041201 PTPRJ, transmembrane domain
      IPR050713 Receptor-type Tyrosine-protein Phosphatases/Ushers
      IPR000242 Tyrosine-specific protein phosphatase, PTPase domain
      IPR000387 Tyrosine-specific protein phosphatases domain
    • GlyGen
      Q64455 37 sites, 25 N-linked glycans (21 sites)
    Molecular
    Reagents
    less
    • All nucleic 27
      Genomic 1
      cDNA 25
      Primer pair 1

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGD-MRK-14303, MGD-MRK-14304, MGD-MRK-26008, MGI:2138959, MGI:98238
    References
    more
    • Summaries
      All 82
      Developmental Gene Expression 7
      Gene Ontology 15
      Phenotypes 33
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:329409 Shalev M, et al., PTPRJ promotes osteoclast maturation and activity by inhibiting Cbl-mediated ubiquitination of NFATc1 in late osteoclastogenesis. FEBS J. 2021 Aug;288(15):4702-4723
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory