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Gapdhs Gene Detail
Summary
  • Symbol
    Gapdhs
  • Name
    glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
  • Synonyms
    Gapd-s, Gapds
  • Feature Type
    protein coding gene
  • IDs
    MGI:95653
    NCBI Gene: 14447
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:30429204-30443106 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 19.23 cM, cytoband A3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    367 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95653
 protein coding gene Chr7:30429200-30443106 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032042
 protein coding gene Chr7:29738638-29750066 (-)
A/J MGP_AJ_G0032019
 protein coding gene Chr7:28929016-28943316 (-)
AKR/J MGP_AKRJ_G0031952
 protein coding gene Chr7:29670487-29687340 (-)
BALB/cJ MGP_BALBcJ_G0032026
 protein coding gene Chr7:29115937-29133959 (-)
C3H/HeJ MGP_C3HHeJ_G0031745
 protein coding gene Chr7:30127309-30142448 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032492
 protein coding gene Chr7:30706250-30734572 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029542
 protein coding gene Chr7:29951773-29965603 (-)
CAST/EiJ MGP_CASTEiJ_G0031079
 protein coding gene Chr7:23381750-23397861 (-)
CBA/J MGP_CBAJ_G0031711
 protein coding gene Chr7:32155231-32171428 (-)
DBA/2J MGP_DBA2J_G0031863
 protein coding gene Chr7:28657086-28671174 (-)
FVB/NJ MGP_FVBNJ_G0031820
 protein coding gene Chr7:28797202-28811525 (-)
LP/J MGP_LPJ_G0031944
 protein coding gene Chr7:30051333-30071643 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031856
 protein coding gene Chr7:31395651-31424043 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032520
 protein coding gene Chr7:29173173-29189536 (-)
PWK/PhJ MGP_PWKPhJ_G0030803
 protein coding gene Chr7:23698427-23718053 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030638
 protein coding gene Chr7:20182521-20200762 (-)
WSB/EiJ MGP_WSBEiJ_G0031189
 protein coding gene Chr7:29576910-29592311 (-)



Homology
more
  • Human Ortholog
    GAPDHS, glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GAPDHS, glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
  • Synonyms
    GAPD2, GAPDH-2, GAPDS, HEL-S-278, HSD-35
  • Links
    NCBI Gene ID: 26330
    neXtProt AC: NX_O14556
    UniProt: O14556

  • Chr Location
    19q13.12; chr19:35533455-35545319 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human GAPDHS associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display male infertility and asthenozoospermia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    831
  • Tissues
    101
  • cDNA Data
    26
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14447 NCBI Gene Model | MGI Sequence Detail 13903 C57BL/6J ±  kb
    transcript NM_008085 RefSeq | MGI Sequence Detail 1476 C57BL/6  
    polypeptide Q64467 UniProt | EBI | MGI Sequence Detail 440 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000007841 glyceraldehyde-3-phosphate dehydrogenase, testis-specific
      (term hierarchy)
    • PDB
      5C7I
    • EC
      1.2.1.12
    • InterPro Domains
      IPR020830 Glyceraldehyde 3-phosphate dehydrogenase, active site
      IPR020829 Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain
      IPR020828 Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain
      IPR006424 Glyceraldehyde-3-phosphate dehydrogenase, type I
      IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family
      IPR036291 NAD(P)-binding domain superfamily
    • GlyGen
      Q64467 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 28
      cDNA 26
      Primer pair 2

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-9980, MGD-MRK-9981
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 4
      Gene Ontology 9
      Phenotypes 10
    • Earliest
      J:843 Welch JE, et al., Expression of a glyceraldehyde 3-phosphate dehydrogenase gene specific to mouse spermatogenic cells. Biol Reprod. 1992 May;46(5):869-78
    • Latest
      J:252087 Huang Z, et al., Sperm function, protein phosphorylation, and metabolism differ in mice lacking successive sperm-specific glycolytic enzymes. Biol Reprod. 2017 Oct 01;97(4):586-597
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    10/29/2024
    MGI 6.24     		The Jackson Laboratory