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St8sia1 Gene Detail
Summary
  • Symbol
    St8sia1
  • Name
    ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
  • Synonyms
    9330109E03Rik, alpha-2,8-sialyltransferase, GD3S, GD3 synthase, Siat8, Siat8a, ST8Sia I
  • Feature Type
    protein coding gene
  • IDs
    MGI:106011
    NCBI Gene: 20449
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:142767271-142910178 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 74.78 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4469 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106011
 protein coding gene Chr6:142767267-142935247 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031471
 protein coding gene Chr6:147636335-147787008 (-)
A/J MGP_AJ_G0031446
 protein coding gene Chr6:141832468-141984845 (-)
AKR/J MGP_AKRJ_G0031374
 protein coding gene Chr6:146052086-146194703 (-)
BALB/cJ MGP_BALBcJ_G0031453
 protein coding gene Chr6:141603829-141749259 (-)
C3H/HeJ MGP_C3HHeJ_G0031175
 protein coding gene Chr6:146091594-146233022 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031915
 protein coding gene Chr6:151683450-151828691 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029039
 protein coding gene Chr6:140658964-140796599 (-)
CAST/EiJ MGP_CASTEiJ_G0030543
 protein coding gene Chr6:145673827-145824051 (-)
CBA/J MGP_CBAJ_G0031135
 protein coding gene Chr6:157450438-157603647 (-)
DBA/2J MGP_DBA2J_G0031292
 protein coding gene Chr6:140668516-140808762 (-)
FVB/NJ MGP_FVBNJ_G0031243
 protein coding gene Chr6:139411058-139542718 (-)
LP/J MGP_LPJ_G0031376
 protein coding gene Chr6:147771512-147928101 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031283
 protein coding gene Chr6:161327975-161485446 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031947
 protein coding gene Chr6:145884077-146035609 (-)
PWK/PhJ MGP_PWKPhJ_G0030270
 protein coding gene Chr6:139147057-139284170 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030094
 protein coding gene Chr6:144078777-144217146 (-)
WSB/EiJ MGP_WSBEiJ_G0030636
 protein coding gene Chr6:146497210-146637090 (-)



Homology
more
  • Human Ortholog
    ST8SIA1, ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ST8SIA1, ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
  • Synonyms
    GD3S, SIAT8, SIAT8-A, SIAT8A, ST8SiaI
  • Links
    NCBI Gene ID: 6489
    neXtProt AC: NX_Q92185
    UniProt: Q92185

  • Chr Location
    12p12.1; chr12:22063773-22437041 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotypes from multigenic genotypes
    47 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted allele are behaviorally normal with no signs of aberrant brain histology or demyelination. Homozygotes for a knock-out allele are behaviorally intact with normal nervous tissue morphology and sensitivity to Fas-mediated apoptosis but show impaired repair of damaged nerves.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    926
  • Tissues
    155
  • cDNA Data
    14
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030283 Ensembl Gene Model | MGI Sequence Detail 142908 C57BL/6J ±  kb
    transcript ENSMUST00000032421 Ensembl | MGI Sequence Detail 8991 Not Applicable  
    polypeptide ENSMUSP00000032421 Ensembl | MGI Sequence Detail 355 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      Genomic 1
      cDNA 15
      Primer pair 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-18769, MGD-MRK-33693, MGI:2444866
    References
    more
    • Summaries
      All 93
      Developmental Gene Expression 12
      Gene Ontology 8
      Phenotypes 47
    • Earliest
      J:26814 Yoshida Y, et al., Molecular cloning of Sia alpha 2,3Gal beta 1,4GlcNAc alpha 2,8-sialyltransferase from mouse brain. J Biol Chem. 1995 Jun 16;270(24):14628-33
    • Latest
      J:352441 Tajima O, et al., Ganglioside GM3 prevents high fat diet-induced hepatosteatosis via attenuated insulin signaling pathway. PLoS One. 2023;18(2):e0281414
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory