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Nlrp9a Gene Detail
Summary
  • Symbol
    Nlrp9a
  • Name
    NLR family, pyrin domain containing 9A
  • Synonyms
    D7Ertd565e, Nalp9a, Nalp-theta
  • Feature Type
    protein coding gene
  • IDs
    MGI:2675292
    NCBI Gene: 233001
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr7:26234448-26273573 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 15.08 cM, cytoband A3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1100 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2675292
 protein coding gene Chr7:26234448-26275040 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031887
 protein coding gene Chr7:25098698-25141970 (+)
A/J MGP_AJ_G0031867
 protein coding gene Chr7:24470544-24522968 (+)
AKR/J MGP_AKRJ_G0031797
 protein coding gene Chr7:25081142-25105161 (+)
BALB/cJ MGP_BALBcJ_G0031872
 protein coding gene Chr7:24664583-24719567 (+)
C3H/HeJ MGP_C3HHeJ_G0031594
 protein coding gene Chr7:25521146-25564967 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032334
 protein coding gene Chr7:25925015-25969088 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029388
 protein coding gene Chr7:25726255-25766097 (+)
CAST/EiJ MGP_CASTEiJ_G0030930
 protein coding gene Chr7:18804846-18844084 (+)
CBA/J MGP_CBAJ_G0031559
 protein coding gene Chr7:26954710-26999759 (+)
DBA/2J MGP_DBA2J_G0031710
 protein coding gene Chr7:24336999-24375426 (+)
FVB/NJ MGP_FVBNJ_G0031667
 protein coding gene Chr7:24422013-24461624 (+)
LP/J MGP_LPJ_G0031791
 protein coding gene Chr7:25366405-25406509 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031700
 protein coding gene Chr7:26586757-26636237 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032367
 protein coding gene Chr7:24704758-24740666 (+)
PWK/PhJ MGP_PWKPhJ_G0030655
 protein coding gene Chr7:19221659-19275930 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030484
 protein coding gene Chr7:15773869-15820515 (+)
WSB/EiJ MGP_WSBEiJ_G0031034
 protein coding gene Chr7:24965246-25009302 (+)



Homology
more
  • Human Ortholog
    NLRP9, NLR family pyrin domain containing 9
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NLRP9, NLR family pyrin domain containing 9
  • Synonyms
    CLR19.1, NALP9, NOD6, PAN12
  • Links
    NCBI Gene ID: 338321
    neXtProt AC: NX_Q7RTR0
    UniProt: Q7RTR0

  • Chr Location
    19q13.42; chr19:55708438-55738402 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from multigenic genotypes
    8 phenotype references
Mice homozygous for null alleles of Nlrp9a, Nlrp9b, and Nlrp9c exhibit reduced litter size, incomplete preimplantation lethality, delayed or impaired blastocyst formation, and failure of cell division at the 2 cell stage.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    9
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    10
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 233001 NCBI Gene Model | MGI Sequence Detail 39126 C57BL/6J ±  kb
transcript NM_001048219 RefSeq | MGI Sequence Detail 3349 ZRU/MplStud  
polypeptide Q66X03 UniProt | EBI | MGI Sequence Detail 949 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000011568 NACHT, LRR and PYD domains-containing protein 9A
    (term hierarchy)
  • InterPro Domains
    IPR004020 DAPIN domain
    IPR011029 Death-like domain superfamily
    IPR001611 Leucine-rich repeat
    IPR032675 Leucine-rich repeat domain superfamily
    IPR041267 NACHT, LRR and PYD domains-containing protein, helical domain HD2
    IPR007111 NACHT nucleoside triphosphatase
    IPR050637 NLRP family, innate immunity and inflammation regulators
    IPR041075 NOD2, winged helix domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
less
  • All nucleic 11
    cDNA 10
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
less
MGI:1261858
References
more
  • Summaries
    All 35
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:302234 Kanzaki S, et al., Involvement of Nlrp9a/b/c in mouse preimplantation development. Reproduction. 2020 Aug;160(2):181-191
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory