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Cltc Gene Detail
Summary
  • Symbol
    Cltc
  • Name
    clathrin heavy chain
  • Synonyms
    CHC
  • Feature Type
    protein coding gene
  • IDs
    MGI:2388633
    NCBI Gene: 67300
  • Alliance
    gene page
  • Transcription Start Sites
    31 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:86585177-86648391 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 51.82 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1232 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2388633
 protein coding gene Chr11:86585177-86648637 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018894
 protein coding gene Chr11:88268495-88334972 (-)
A/J MGP_AJ_G0018861
 protein coding gene Chr11:84874119-84938601 (-)
AKR/J MGP_AKRJ_G0018831
 protein coding gene Chr11:87413828-87479520 (-)
BALB/cJ MGP_BALBcJ_G0018834
 protein coding gene Chr11:85255838-85318929 (-)
C3H/HeJ MGP_C3HHeJ_G0018648
 protein coding gene Chr11:87435554-87511791 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019286
 protein coding gene Chr11:90929597-90996336 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016919
 protein coding gene Chr11:81894396-81957082 (-)
CAST/EiJ MGP_CASTEiJ_G0018203
 protein coding gene Chr11:88129399-88197594 (-)
CBA/J MGP_CBAJ_G0018619
 protein coding gene Chr11:94755066-94824211 (-)
DBA/2J MGP_DBA2J_G0018727
 protein coding gene Chr11:84443106-84506563 (-)
FVB/NJ MGP_FVBNJ_G0018716
 protein coding gene Chr11:83944439-84006676 (-)
LP/J MGP_LPJ_G0018797
 protein coding gene Chr11:88756840-88822770 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018743
 protein coding gene Chr11:94859730-94926683 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019326
 protein coding gene Chr11:87657155-87725547 (-)
PWK/PhJ MGP_PWKPhJ_G0017973
 protein coding gene Chr11:85239673-85305280 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017765
 protein coding gene Chr11:87211500-87276704 (-)
WSB/EiJ MGP_WSBEiJ_G0018254
 protein coding gene Chr11:87529691-87596700 (-)



Homology
more
  • Human Ortholog
    CLTC, clathrin heavy chain
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CLTC, clathrin heavy chain
  • Synonyms
    CHC, CHC17, CLH-17, CLTCL2, Hc, MRD56
  • Links
    NCBI Gene ID: 1213
    neXtProt AC: NX_Q00610
    UniProt: Q00610

  • Chr Location
    17q23.1; chr17:59619680-59696956 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CLTC associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    75
  • GO References
    22
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    718
  • Tissues
    8
  • cDNA Data
    771
  • Literature Summary
    24
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000047126 Ensembl Gene Model | MGI Sequence Detail 63215 C57BL/6J ±  kb
transcript ENSMUST00000060766 Ensembl | MGI Sequence Detail 6163 Not Applicable  
polypeptide ENSMUSP00000050220 Ensembl | MGI Sequence Detail 1679 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    9 Sequences
  • Protein Ontology
    PR:000030907 clathrin heavy chain 1
    (term hierarchy)
  • PDB
    5ODS
  • InterPro Domains
    IPR016024 Armadillo-type fold
    IPR016341 Clathrin, heavy chain
    IPR015348 Clathrin, heavy chain, linker, core motif
    IPR016025 Clathrin heavy chain, N-terminal
    IPR022365 Clathrin, heavy chain, propeller repeat
    IPR000547 Clathrin, heavy chain/VPS, 7-fold repeat
    IPR011990 Tetratricopeptide-like helical domain superfamily
  • GlyGen
    Q68FD5 6 sites, 5 N-linked glycans (5 sites), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 774
    cDNA 772
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGI:1914550, MGI:2144696
References
more
  • Summaries
    All 107
    Developmental Gene Expression 24
    Gene Ontology 22
    Phenotypes 16
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:340878 Yang Y, et al., USP25-PKM2-glycolysis axis contributes to ischemia reperfusion-induced acute kidney injury by promoting M1-like macrophage polarization and proinflammatory response. Clin Immunol. 2023 Jun;251:109279
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory