Fnip1 MGI Mouse Gene Detail - MGI:2444668 - folliculin interacting protein 1

Symbol

Fnip1
Name

folliculin interacting protein 1
Synonyms

A730024A03Rik, mKIAA1961

Feature Type

protein coding gene
IDs

MGI:2444668
NCBI Gene: 216742
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr11:54329025-54409061 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 32.13 cM
Mapping Data

2 experiments

SNPs within 2kb

1208 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2444668	protein coding gene	Chr11:54328071-54409067 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018316	protein coding gene	Chr11:53911801-53996347 (+)
A/J	MGP_AJ_G0018285	protein coding gene	Chr11:51900240-51981414 (+)
AKR/J	MGP_AKRJ_G0018254	protein coding gene	Chr11:53603530-53686889 (+)
BALB/cJ	MGP_BALBcJ_G0018256	protein coding gene	Chr11:52242914-52323975 (+)
C3H/HeJ	MGP_C3HHeJ_G0018067	protein coding gene	Chr11:53537021-53617343 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018708	protein coding gene	Chr11:55565816-55656083 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016358	protein coding gene	Chr11:49345821-49425927 (+)
CAST/EiJ	MGP_CASTEiJ_G0017632	protein coding gene	Chr11:53584744-53668487 (+)
CBA/J	MGP_CBAJ_G0018042	protein coding gene	Chr11:58199013-58282026 (+)
DBA/2J	MGP_DBA2J_G0018151	protein coding gene	Chr11:51612092-51692260 (+)
FVB/NJ	MGP_FVBNJ_G0018143	protein coding gene	Chr11:51259766-51339558 (+)
LP/J	MGP_LPJ_G0018226	protein coding gene	Chr11:54364057-54449311 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018169	protein coding gene	Chr11:59396695-59508147 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018750	protein coding gene	Chr11:53612625-53695730 (+)
PWK/PhJ	MGP_PWKPhJ_G0017405	protein coding gene	Chr11:52151023-52232231 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017200	protein coding gene	Chr11:53391312-53478485 (+)
WSB/EiJ	MGP_WSBEiJ_G0017680	protein coding gene	Chr11:53248124-53334980 (+)

Human Ortholog

FNIP1, folliculin interacting protein 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FNIP1, folliculin interacting protein 1
Synonyms

IMD93
Links

HGNC:29418

NCBI Gene ID: 96459

neXtProt AC: NX_Q8TF40

UniProt: Q8TF40
Chr Location

5q31.1; chr5:131641714-131797017 (-) GRCh38

MGI Vertebrate Homology

Fnip1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FNIP1
Gene Tree

Fnip1

Diseases

1 with human FNIP1 associations

				Human Disease	Mouse Models
				primary immunodeficiency disease IDs primary immunodeficiency disease DOID:612 ICD10CM:D84.9 ICD9CM:279.3 KEGG:05340 MESH:D007153 NCI:C39725 OMIM:242850 OMIM:PS300755 UMLS_CUI:C0021051

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

80 phenotypes from 8 alleles in 10 genetic backgrounds
14 phenotypes from multigenic genotypes
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (ENU)

4
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

2
Targeted

2
Genomic Mutations

1 involving Fnip1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

60 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for an ENU-induced or targeted allele exhibit arrested B cell development at the pre-B cell stage with increased B cell apoptosis.

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All GO Annotations

45
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

61

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fnip1

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All Sequences

49
RefSeq

8
UniProt

2
CCDS

CCDS24698.1

Ensembl

ENSMUSG00000035992 (Evidence)
NCBI Gene

216742

			Length	Strain/Species	Flank
genomic	ENSMUSG00000035992	Ensembl Gene Model \| MGI Sequence Detail	80037	C57BL/6J	± kb
transcript	ENSMUST00000046835	Ensembl \| MGI Sequence Detail	6255	Not Applicable
polypeptide	ENSMUSP00000049026	Ensembl \| MGI Sequence Detail	1165	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000007589 folliculin-interacting protein 1

(term hierarchy)
PDB

7ROY
InterPro Domains

IPR028086 Folliculin-interacting protein, C-terminal domain

IPR026156 Folliculin-interacting protein family

IPR028085 Folliculin-interacting protein, middle domain

IPR028084 Folliculin-interacting protein, N-terminal domain

IPR037545 Tripartite DENN domain, FNIP1/2-type
GlyGen

Q68FD7 1 site

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All nucleic 61

cDNA 61

Microarray probesets 7

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MGI:2144273, MGI:2144575

Summaries

All 52

Diseases 1

Gene Ontology 8

Phenotypes 21
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:350273 Shillingford JM, et al., Functional TFEB activation characterizes multiple models of renal cystic disease and loss of polycystin-1. Am J Physiol Renal Physiol. 2023 Apr 1;324(4):F404-F422

TSS for Fnip1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr101495	Chr11:54328594-54328599 (+)	-428 bp
Tssr101496	Chr11:54328985-54329013 (+)	-26 bp
Tssr101497	Chr11:54329014-54329046 (+)	5 bp
Tssr101498	Chr11:54329099-54329110 (+)	80 bp
Tssr101503	Chr11:54377247-54377250 (+)	48,224 bp
Tssr101504	Chr11:54386861-54386865 (+)	57,838 bp
Tssr101505	Chr11:54398104-54398113 (+)	69,084 bp
Tssr101506	Chr11:54406982-54406993 (+)	77,963 bp
Tssr101507	Chr11:54407124-54407146 (+)	78,110 bp
Tssr101508	Chr11:54407541-54407554 (+)	78,523 bp
Tssr101509	Chr11:54407603-54407615 (+)	78,584 bp
Tssr101510	Chr11:54407625-54407628 (+)	78,602 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24