Atg9a MGI Mouse Gene Detail - MGI:2138446

Symbol

Atg9a
Name

autophagy related 9A
Synonyms

Apg9l1

Feature Type

protein coding gene
IDs

MGI:2138446
NCBI Gene: 245860
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr1:75157509-75168654 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 38.62 cM
Mapping Data

1 experiment

SNPs within 2kb

305 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2138446	protein coding gene	Chr1:75157504-75168840 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016175	protein coding gene	Chr1:75743098-75755590 (-)
A/J	MGP_AJ_G0016158	protein coding gene	Chr1:73102641-73114366 (-)
AKR/J	MGP_AKRJ_G0016115	protein coding gene	Chr1:75131627-75142968 (-)
BALB/cJ	MGP_BALBcJ_G0016113	protein coding gene	Chr1:73164660-73175995 (-)
C3H/HeJ	MGP_C3HHeJ_G0015944	protein coding gene	Chr1:75462221-75474363 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0016566	protein coding gene	Chr1:78693608-78704944 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014287	protein coding gene	Chr1:68663596-68675074 (-)
CAST/EiJ	MGP_CASTEiJ_G0015528	protein coding gene	Chr1:74800516-74811823 (-)
CBA/J	MGP_CBAJ_G0015917	protein coding gene	Chr1:81251818-81263148 (-)
DBA/2J	MGP_DBA2J_G0016018	protein coding gene	Chr1:72421550-72432655 (-)
FVB/NJ	MGP_FVBNJ_G0016021	protein coding gene	Chr1:71619825-71631172 (-)
LP/J	MGP_LPJ_G0016090	protein coding gene	Chr1:76867018-76878354 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016041	protein coding gene	Chr1:84610047-84622632 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016613	protein coding gene	Chr1:75201455-75212799 (-)
PWK/PhJ	MGP_PWKPhJ_G0015315	protein coding gene	Chr1:71891202-71902559 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015093	protein coding gene	Chr1:74561895-74573234 (-)
WSB/EiJ	MGP_WSBEiJ_G0015590	protein coding gene	Chr1:75012710-75025226 (-)

Human Ortholog

ATG9A, autophagy related 9A

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ATG9A, autophagy related 9A
Synonyms

APG9L1, mATG9, MGD3208
Links

HGNC:22408

NCBI Gene ID: 79065

neXtProt AC: NX_Q7Z3C6

UniProt: Q7Z3C6
Chr Location

2q35; chr2:219219380-219229717 (-) GRCh38

MGI Vertebrate Homology

Atg9a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ATG9A
Gene Tree

Atg9a

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References

1 with disease annotations

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
32 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

1
Endonuclease-mediated

4
Radiation induced

2
Spontaneous

1
Targeted

5
Genomic Mutations

4 involving Atg9a
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

44 strains or lines available

Mice homozygous for a null mutation all die within 1 day of birth and display impaired autophagy.

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All GO Annotations

48
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

739
Tissues

11
cDNA Data

43
Literature Summary

6

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase atg9a

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All Sequences

82
RefSeq

20
UniProt

7
CCDS

CCDS35622.1

Ensembl

ENSMUSG00000033124 (Evidence)
NCBI Gene

245860

			Length	Strain/Species	Flank
genomic	245860	NCBI Gene Model \| MGI Sequence Detail	11146	C57BL/6J	± kb
transcript	NR_176609	RefSeq \| MGI Sequence Detail	4032	C57BL/6
polypeptide	Q68FE2	UniProt \| EBI \| MGI Sequence Detail	839	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000004420 autophagy-related protein 9A

(term hierarchy)
InterPro Domains

IPR007241 Autophagy-related protein 9
GlyGen

Q68FE2 1 site, 1 N-linked glycan (1 site)

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All nucleic 45

Genomic 1

cDNA 43

Primer pair 1

Microarray probesets 3

Summaries

All 75

Developmental Gene Expression 6

Diseases 1

Gene Ontology 16

Phenotypes 32
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:341021 Zhang J, et al., HSF4 Transcriptionally Activates Autophagy by Regulating ATG9a During Lens Terminal Differentiation. Invest Ophthalmol Vis Sci. 2023 Jun 1;64(7):5

TSS for Atg9a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr12366	Chr1:75169275-75169326 (-)	-647 bp
Tssr12365	Chr1:75168648-75168660 (-)	0 bp
Tssr12364	Chr1:75168578-75168641 (-)	44 bp
Tssr12363	Chr1:75168326-75168379 (-)	301 bp
Tssr12362	Chr1:75166994-75167025 (-)	1,644 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24