Ric1 MGI Mouse Gene Detail - MGI:1924893 - RAB6A GEF complex partner 1

Symbol

Ric1
Name

RAB6A GEF complex partner 1
Synonyms

C030046E11Rik, C130057E09Rik

Feature Type

protein coding gene
IDs

MGI:1924893
NCBI Gene: 226089
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr19:29499637-29583909 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 24.07 cM
Mapping Data

3 experiments

SNPs within 2kb

1891 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1924893	protein coding gene	Chr19:29499637-29584229 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025024	protein coding gene	Chr19:27987891-28072900 (+)
A/J	MGP_AJ_G0025001	protein coding gene	Chr19:26574939-26661455 (+)
AKR/J	MGP_AKRJ_G0024969	protein coding gene	Chr19:27544319-27630198 (+)
BALB/cJ	MGP_BALBcJ_G0025000	protein coding gene	Chr19:26624783-26715414 (+)
C3H/HeJ	MGP_C3HHeJ_G0024756	protein coding gene	Chr19:27511817-27599467 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025441	protein coding gene	Chr19:28761740-28850871 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022860	protein coding gene	Chr19:26546454-26632707 (+)
CAST/EiJ	MGP_CASTEiJ_G0024226	protein coding gene	Chr19:27355612-27456592 (+)
CBA/J	MGP_CBAJ_G0024734	protein coding gene	Chr19:30106428-30203195 (+)
DBA/2J	MGP_DBA2J_G0024866	protein coding gene	Chr19:26532367-26616238 (+)
FVB/NJ	MGP_FVBNJ_G0024828	protein coding gene	Chr19:26390116-26471913 (+)
LP/J	MGP_LPJ_G0024951	protein coding gene	Chr19:27984656-28071735 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024855	protein coding gene	Chr19:30049918-30140709 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025496	protein coding gene	Chr19:27552818-27645287 (+)
PWK/PhJ	MGP_PWKPhJ_G0023974	protein coding gene	Chr19:26208794-26307473 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023778	protein coding gene	Chr19:26836618-26922561 (+)
WSB/EiJ	MGP_WSBEiJ_G0024293	protein coding gene	Chr19:27610983-27697124 (+)

Human Ortholog

RIC1, RIC1 homolog, RAB6A GEF complex partner 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RIC1, RIC1 homolog, RAB6A GEF complex partner 1
Synonyms

bA207C16.1, CATIFA, CIP150, KIAA1432
Links

HGNC:17686

NCBI Gene ID: 57589

neXtProt AC: NX_Q4ADV7

UniProt: Q4ADV7
Chr Location

9p24.1; chr9:5629025-5778633 (+) GRCh38

MGI Vertebrate Homology

Ric1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RIC1
Gene Tree

Ric1

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Phenotype Summary

13 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Gene trapped

6
Targeted

5
Genomic Mutations

3 involving Ric1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

58 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

26
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

35

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ric1

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All Sequences

59
RefSeq

7
UniProt

6
CCDS

CCDS37951.1

Ensembl

ENSMUSG00000038658 (Evidence)
NCBI Gene

226089

			Length	Strain/Species	Flank
genomic	226089	NCBI Gene Model \| MGI Sequence Detail	84273	C57BL/6J	± kb
transcript	NM_001081319	RefSeq \| MGI Sequence Detail	6282	Not Specified
polypeptide	Q69ZJ7	UniProt \| EBI \| MGI Sequence Detail	1422	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000060150 guanine nucleotide exchange factor subunit RIC1

(term hierarchy)
InterPro Domains

IPR011044 Quinoprotein amine dehydrogenase, beta chain-like

IPR040096 RAB6A-GEF complex partner protein 1

IPR009771 Ribosome control protein 1

IPR036322 WD40-repeat-containing domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily

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All nucleic 35

cDNA 35

Microarray probesets 3

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MGI:3041191

Summaries

All 31

Gene Ontology 4

Phenotypes 6
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ric1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr155900	Chr19:29499663-29499741 (+)	65 bp
Tssr155901	Chr19:29499780-29499791 (+)	149 bp
Tssr155902	Chr19:29499812-29499823 (+)	181 bp
Tssr155903	Chr19:29514561-29514570 (+)	14,929 bp
Tssr155904	Chr19:29561450-29561477 (+)	61,827 bp
Tssr155905	Chr19:29583151-29583166 (+)	83,522 bp
Tssr155906	Chr19:29583619-29583623 (+)	83,984 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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