Fgd6 MGI Mouse Gene Detail - MGI:1261419 - FYVE, RhoGEF and PH domain containing 6

Symbol

Fgd6
Name

FYVE, RhoGEF and PH domain containing 6
Synonyms

Etohd4, ZFYVE24

Feature Type

protein coding gene
IDs

MGI:1261419
NCBI Gene: 13998
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr10:93871863-93981201 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 48.76 cM, cytoband C3
Mapping Data

3 experiments

SNPs within 2kb

3542 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1261419	protein coding gene	Chr10:93871862-93981201 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017660	protein coding gene	Chr10:95486980-95609487 (+)
A/J	MGP_AJ_G0017639	protein coding gene	Chr10:92149300-92258449 (+)
AKR/J	MGP_AKRJ_G0017597	protein coding gene	Chr10:94788246-94900402 (+)
BALB/cJ	MGP_BALBcJ_G0017602	protein coding gene	Chr10:92421810-92532826 (+)
C3H/HeJ	MGP_C3HHeJ_G0017425	protein coding gene	Chr10:94781138-94895163 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018059	protein coding gene	Chr10:98650128-98764237 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015740	protein coding gene	Chr10:87730378-87841894 (+)
CAST/EiJ	MGP_CASTEiJ_G0016990	protein coding gene	Chr10:94781387-94897572 (+)
CBA/J	MGP_CBAJ_G0017394	protein coding gene	Chr10:102727247-102848603 (+)
DBA/2J	MGP_DBA2J_G0017500	protein coding gene	Chr10:91242571-91353098 (+)
FVB/NJ	MGP_FVBNJ_G0017492	protein coding gene	Chr10:90481632-90593213 (+)
LP/J	MGP_LPJ_G0017574	protein coding gene	Chr10:96097784-96217823 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017523	protein coding gene	Chr10:103993422-104110538 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018096	protein coding gene	Chr10:94684373-94803377 (+)
PWK/PhJ	MGP_PWKPhJ_G0016771	protein coding gene	Chr10:91336914-91449025 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016559	protein coding gene	Chr10:93489375-93602188 (+)
WSB/EiJ	MGP_WSBEiJ_G0017049	protein coding gene	Chr10:94656643-94769021 (+)

Human Ortholog

FGD6, FYVE, RhoGEF and PH domain containing 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FGD6, FYVE, RhoGEF and PH domain containing 6
Synonyms

ZFYVE24
Links

HGNC:21740

NCBI Gene ID: 55785

neXtProt AC: NX_Q6ZV73

UniProt: Q6ZV73
Chr Location

12q22; chr12:95076749-95217482 (-) GRCh38

MGI Vertebrate Homology

Fgd6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FGD6
Gene Tree

Fgd6

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Phenotype Summary

12 phenotype references

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

4
Targeted

2
Transposon induced

1
Genomic Mutations

2 involving Fgd6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

44 strains or lines available

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All GO Annotations

6
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

710
Tissues

1
cDNA Data

9
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA FGD6

Xenbase fgd6

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All Sequences

47
RefSeq

8
UniProt

2
CCDS

CCDS48674.1

Ensembl

ENSMUSG00000020021 (Evidence)
NCBI Gene

13998

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020021	Ensembl Gene Model \| MGI Sequence Detail	109339	C57BL/6J	± kb
transcript	ENSMUST00000020208	Ensembl \| MGI Sequence Detail	8044	Not Applicable
polypeptide	ENSMUSP00000020208	Ensembl \| MGI Sequence Detail	1399	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000007478 FYVE, RhoGEF and PH domain-containing protein 6

(term hierarchy)
PDB

1WGQ
InterPro Domains

IPR000219 Dbl homology (DH) domain

IPR035899 Dbl homology (DH) domain superfamily

IPR037743 FGD6, N-terminal PH domain

IPR051092 FYVE, RhoGEF and PH domain-containing

IPR000306 FYVE zinc finger

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

IPR017455 Zinc finger, FYVE-related

IPR013083 Zinc finger, RING/FYVE/PHD-type

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All nucleic 10

cDNA 9

Primer pair 1

Microarray probesets 4

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MGI:3034294

Summaries

All 38

Developmental Gene Expression 1

Gene Ontology 3

Phenotypes 12
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:302089 Vezzali R, et al., The FOXG1/FOXO/SMAD network balances proliferation and differentiation of cortical progenitors and activates Kcnh3 expression in mature neurons. Oncotarget. 2016 Jun 21;7(25):37436-37455

TSS for Fgd6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr95293	Chr10:93871311-93871333 (+)	-541 bp
Tssr95294	Chr10:93871906-93871917 (+)	49 bp
Tssr95295	Chr10:93871919-93871983 (+)	88 bp
Tssr3327	Chr10:93872226-93872237 (+)	369 bp
Tssr95296	Chr10:93872808-93872843 (+)	963 bp
Tssr95297	Chr10:93893223-93893228 (+)	21,363 bp
Tssr95298	Chr10:93909258-93909277 (+)	37,405 bp
Tssr95299	Chr10:93909901-93909906 (+)	38,041 bp
Tssr95300	Chr10:93919723-93919724 (+)	47,861 bp
Tssr95301	Chr10:93950576-93950590 (+)	78,720 bp
Tssr95302	Chr10:93969210-93969222 (+)	97,353 bp
Tssr95303	Chr10:93977160-93977190 (+)	105,312 bp
Tssr95304	Chr10:93978700-93978711 (+)	106,843 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24