Scap MGI Mouse Gene Detail - MGI:2135958

Symbol

Scap
Name

SREBF chaperone

Feature Type

protein coding gene
IDs

MGI:2135958
NCBI Gene: 235623
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr9:110162356-110214017 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 59.91 cM
Mapping Data

5 experiments

SNPs within 2kb

1215 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2135958	protein coding gene	Chr9:110162356-110214018 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035345	protein coding gene	Chr9:112476785-112530388 (+)
A/J	MGP_AJ_G0035326	protein coding gene	Chr9:108390652-108442328 (+)
AKR/J	MGP_AKRJ_G0035257	protein coding gene	Chr9:111082989-111135483 (+)
BALB/cJ	MGP_BALBcJ_G0035321	protein coding gene	Chr9:108134256-108187574 (+)
C3H/HeJ	MGP_C3HHeJ_G0035029	protein coding gene	Chr9:111587257-111639735 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035843	protein coding gene	Chr9:115529257-115583108 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032729	protein coding gene	Chr9:105615268-105664158 (+)
CAST/EiJ	MGP_CASTEiJ_G0034335	protein coding gene	Chr9:111373633-111426079 (+)
CBA/J	MGP_CBAJ_G0034996	protein coding gene	Chr9:119831798-119890169 (+)
DBA/2J	MGP_DBA2J_G0035155	protein coding gene	Chr9:107852361-107904253 (+)
FVB/NJ	MGP_FVBNJ_G0035102	protein coding gene	Chr9:106676636-106728392 (+)
LP/J	MGP_LPJ_G0035234	protein coding gene	Chr9:112770817-112826150 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035142	protein coding gene	Chr9:121190773-121244391 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035863	protein coding gene	Chr9:111411309-111462422 (+)
PWK/PhJ	MGP_PWKPhJ_G0034042	protein coding gene	Chr9:108092751-108146618 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033877	protein coding gene	Chr9:111501887-111554678 (+)
WSB/EiJ	MGP_WSBEiJ_G0034456	protein coding gene	Chr9:111288506-111341025 (+)

Human Ortholog

SCAP, SREBF chaperone

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SCAP, SREBF chaperone
Links

HGNC:30634

NCBI Gene ID: 22937

neXtProt AC: NX_Q12770

UniProt: Q12770
Chr Location

3p21.31; chr3:47413681-47477127 (-) GRCh38

MGI Vertebrate Homology

Scap stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SCAP
Gene Tree

Scap

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Phenotype Summary

6 phenotypes from 2 alleles in 2 genetic backgrounds
48 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

35
Endonuclease-mediated

7
Gene trapped

24
Targeted

3
Transgenic

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

62 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a transgenic gene disruption exhibit decreased body size.

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All GO Annotations

30
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

721
Tissues

11
cDNA Data

21
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase scap

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All Sequences

101
RefSeq

10
UniProt

4
CCDS

CCDS23564.1

Ensembl

ENSMUSG00000032485 (Evidence)
NCBI Gene

235623

			Length	Strain/Species	Flank
genomic	235623	NCBI Gene Model \| MGI Sequence Detail	51662	C57BL/6J	± kb
transcript	NM_001410582	RefSeq \| MGI Sequence Detail	4418	ZRU/MplStud
polypeptide	Q6GQT6	UniProt \| EBI \| MGI Sequence Detail	1276	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000014489 sterol regulatory element-binding protein cleavage-activating protein

(term hierarchy)
InterPro Domains

IPR030225 Sterol regulatory element-binding protein cleavage-activating protein

IPR000731 Sterol-sensing domain

IPR001680 WD40 repeat

IPR019775 WD40 repeat, conserved site

IPR036322 WD40-repeat-containing domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily
GlyGen

Q6GQT6 3 sites, 4 N-linked glycans (2 sites)

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All nucleic 25

cDNA 24

Primer pair 1

Microarray probesets 3

Summaries

All 93

Developmental Gene Expression 7

Gene Ontology 11

Phenotypes 48
Earliest

J:69592 Matsuda M, et al., SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation. Genes Dev. 2001 May 15;15(10):1206-16
Latest

J:355268 Huang Y, et al., The role of KLF2 in regulating hepatic lipogenesis and blood cholesterol homeostasis via the SCAP/SREBP pathway. J Lipid Res. 2024 Jan;65(1):100472

TSS for Scap:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr87345	Chr9:110162344-110162390 (+)	11 bp
Tssr87346	Chr9:110162408-110162457 (+)	77 bp
Tssr87347	Chr9:110162470-110162503 (+)	131 bp
Tssr87348	Chr9:110173139-110173145 (+)	10,786 bp
Tssr87349	Chr9:110173231-110173248 (+)	10,884 bp
Tssr87350	Chr9:110173253-110173272 (+)	10,907 bp
Tssr87351	Chr9:110173277-110173297 (+)	10,931 bp
Tssr87352	Chr9:110173319-110173330 (+)	10,969 bp
Tssr87353	Chr9:110191501-110191538 (+)	29,164 bp
Tssr87354	Chr9:110210009-110210017 (+)	47,657 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24