About   Help   FAQ
Kdsr Gene Detail
Summary
  • Symbol
    Kdsr
  • Name
    3-ketodihydrosphingosine reductase
  • Synonyms
    6330410P18Rik, 9430079B08Rik, Fvt1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918000
    NCBI Gene: 70750
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:106648189-106687457 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 49.99 cM, cytoband D
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1119 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918000
 protein coding gene Chr1:106648140-106689544 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016372
 protein coding gene Chr1:108900258-108942653 (-)
A/J MGP_AJ_G0016356
 protein coding gene Chr1:105083943-105122364 (-)
AKR/J MGP_AKRJ_G0016316
 protein coding gene Chr1:107956140-107994618 (-)
BALB/cJ MGP_BALBcJ_G0016312
 protein coding gene Chr1:105181456-105218941 (-)
C3H/HeJ MGP_C3HHeJ_G0016139
 protein coding gene Chr1:108407268-108447685 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016771
 protein coding gene Chr1:113041437-113081152 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014489
 protein coding gene Chr1:99389926-99427173 (-)
CAST/EiJ MGP_CASTEiJ_G0015721
 protein coding gene Chr1:107328649-107371998 (-)
CBA/J MGP_CBAJ_G0016112
 protein coding gene Chr1:116910307-116951280 (-)
DBA/2J MGP_DBA2J_G0016217
 protein coding gene Chr1:104153229-104191600 (-)
FVB/NJ MGP_FVBNJ_G0016218
 protein coding gene Chr1:103085718-103123490 (-)
LP/J MGP_LPJ_G0016291
 protein coding gene Chr1:110141898-110178521 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016244
 protein coding gene Chr1:121319768-121358616 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016810
 protein coding gene Chr1:108044742-108085360 (-)
PWK/PhJ MGP_PWKPhJ_G0015509
 protein coding gene Chr1:103176515-103212939 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015294
 protein coding gene Chr1:106702102-106740368 (-)
WSB/EiJ MGP_WSBEiJ_G0015784
 protein coding gene Chr1:107873842-107912944 (-)



Homology
more
  • Human Ortholog
    KDSR, 3-ketodihydrosphingosine reductase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KDSR, 3-ketodihydrosphingosine reductase
  • Synonyms
    DHSR, EKVP4, FVT1, SDR35C1
  • Links
    NCBI Gene ID: 2531
    neXtProt AC: NX_Q06136
    UniProt: Q06136

  • Chr Location
    18q21.33; chr18:63327726-63367228 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human KDSR associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    805
  • Tissues
    97
  • cDNA Data
    9
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000009905 Ensembl Gene Model | MGI Sequence Detail 39269 C57BL/6J ±  kb
transcript ENSMUST00000010049 Ensembl | MGI Sequence Detail 5518 Not Applicable  
polypeptide ENSMUSP00000010049 Ensembl | MGI Sequence Detail 332 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 10
    cDNA 9
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGI:2444125
References
more
  • Summaries
    All 43
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 10
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:335426 Butera A, et al., ZFP750 affects the cutaneous barrier through regulating lipid metabolism. Sci Adv. 2023 Apr 28;9(17):eadg5423
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory