Utf1 MGI Mouse Gene Detail - MGI:1276125 - undifferentiated embryonic cell transcription factor 1

Symbol

Utf1
Name

undifferentiated embryonic cell transcription factor 1

Feature Type

protein coding gene
IDs

MGI:1276125
NCBI Gene: 22286
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr7:139523769-139525025 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 84.91 cM, cytoband F5
Mapping Data

4 experiments

SNPs within 2kb

133 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1276125	protein coding gene	Chr7:139523702-139525025 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033155	protein coding gene	Chr7:145019299-145020622 (+)
A/J	MGP_AJ_G0033137	protein coding gene	Chr7:140899797-140901120 (+)
AKR/J	MGP_AKRJ_G0033069	protein coding gene	Chr7:144732837-144734160 (+)
BALB/cJ	MGP_BALBcJ_G0033138	protein coding gene	Chr7:140639238-140640561 (+)
C3H/HeJ	MGP_C3HHeJ_G0032852	protein coding gene	Chr7:144533033-144534356 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033649	protein coding gene	Chr7:150361044-150362367 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030622	protein coding gene	Chr7:142024532-142025852 (+)
CAST/EiJ	MGP_CASTEiJ_G0032182	protein coding gene	Chr7:136834632-136835955 (+)
CBA/J	MGP_CBAJ_G0032825	protein coding gene	Chr7:155430107-155431430 (+)
DBA/2J	MGP_DBA2J_G0032977	protein coding gene	Chr7:138854023-138855346 (+)
FVB/NJ	MGP_FVBNJ_G0032930	protein coding gene	Chr7:138740235-138741558 (+)
LP/J	MGP_LPJ_G0033071	protein coding gene	Chr7:146563714-146565037 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032962	protein coding gene	Chr7:156094982-156096305 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033669	protein coding gene	Chr7:143734742-143736065 (+)
PWK/PhJ	MGP_PWKPhJ_G0031888	protein coding gene	Chr7:132048534-132049857 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031733	protein coding gene	Chr7:130570924-130572247 (+)
WSB/EiJ	MGP_WSBEiJ_G0032293	protein coding gene	Chr7:144631349-144632672 (+)

Human Ortholog

UTF1, undifferentiated embryonic cell transcription factor 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

UTF1, undifferentiated embryonic cell transcription factor 1
Links

HGNC:12634

NCBI Gene ID: 8433

neXtProt AC: NX_Q5T230

UniProt: Q5T230
Chr Location

10q26.3; chr10:133230217-133231558 (+) GRCh38

MGI Vertebrate Homology

Utf1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: UTF1
Gene Tree

Utf1

less

Phenotype Summary

13 phenotypes from 1 allele in 2 genetic backgrounds
6 images
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Endonuclease-mediated

5
Gene trapped

3
Radiation induced

1
Targeted

5
Genomic Mutations

1 involving Utf1
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit growth retardation and background sensitive neo- and postnatal lethality.

less

All GO Annotations

13
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

802
Tissues

46
cDNA Data

11
Literature Summary

14

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

less

All Sequences

37
RefSeq

2
UniProt

2
CCDS

CCDS21958.1

Ensembl

ENSMUSG00000047751 (Evidence)
NCBI Gene

22286

			Length	Strain/Species	Flank
genomic	22286	NCBI Gene Model \| MGI Sequence Detail	1257	C57BL/6J	± kb
transcript	NM_009482	RefSeq \| MGI Sequence Detail	1160	C57BL/6
polypeptide	Q6J1H4	UniProt \| EBI \| MGI Sequence Detail	339	Not Applicable

less

UniProt

2 Sequences
Protein Ontology

PR:000017200 undifferentiated embryonic cell transcription factor 1

(term hierarchy)
InterPro Domains

IPR044822 Myb/SANT-like DNA-binding domain 4
GlyGen

Q6J1H4 2 sites, 1 O-linked glycan (2 sites)

less

All nucleic 15

Genomic 1

cDNA 11

Primer pair 1

Other 2

Microarray probesets 5

less

MGI:2141991

Summaries

All 51

Developmental Gene Expression 14

Gene Ontology 5

Phenotypes 14
Earliest

J:47012 Okuda A, et al., UTF1, a novel transcriptional coactivator expressed in pluripotent embryonic stem cells and extra-embryonic cells. EMBO J. 1998 Apr 1;17(7):2019-32
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Utf1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr69753	Chr7:139523673-139523682 (+)	-91 bp
Tssr69754	Chr7:139523694-139523707 (+)	-68 bp
Tssr69755	Chr7:139523726-139523788 (+)	-12 bp
Tssr69756	Chr7:139523791-139523828 (+)	41 bp
Tssr69757	Chr7:139523881-139523888 (+)	116 bp
Tssr69758	Chr7:139524426-139524449 (+)	669 bp
Tssr69759	Chr7:139524459-139524467 (+)	694 bp
Tssr69760	Chr7:139524492-139524499 (+)	727 bp
Tssr69761	Chr7:139524526-139524536 (+)	762 bp
Tssr69762	Chr7:139524561-139524568 (+)	796 bp
Tssr69763	Chr7:139524579-139524592 (+)	817 bp
Tssr69764	Chr7:139524604-139524623 (+)	845 bp
Tssr69765	Chr7:139524660-139524676 (+)	899 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24