Plekhg2 MGI Mouse Gene Detail - MGI:2141874 - pleckstrin homology domain containing, family G (with RhoGef domain) member 2

Symbol

Plekhg2
Name

pleckstrin homology domain containing, family G (with RhoGef domain) member 2
Synonyms

Clg

Feature Type

protein coding gene
IDs

MGI:2141874
NCBI Gene: 101497
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr7:28059029-28072024 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 16.71 cM
Mapping Data

1 experiment

SNPs within 2kb

421 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2141874	protein coding gene	Chr7:28059028-28072818 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0031941	protein coding gene	Chr7:27142339-27155345 (-)
A/J	MGP_AJ_G0031920	protein coding gene	Chr7:26482974-26496317 (-)
AKR/J	MGP_AKRJ_G0031851	protein coding gene	Chr7:27159280-27171998 (-)
BALB/cJ	MGP_BALBcJ_G0031926	protein coding gene	Chr7:26641770-26654708 (-)
C3H/HeJ	MGP_C3HHeJ_G0031648	protein coding gene	Chr7:27537508-27550927 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0032391	protein coding gene	Chr7:28014017-28027014 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029443	protein coding gene	Chr7:27556942-27569854 (-)
CAST/EiJ	MGP_CASTEiJ_G0030983	protein coding gene	Chr7:20843505-20856274 (-)
CBA/J	MGP_CBAJ_G0031611	protein coding gene	Chr7:29282755-29295708 (-)
DBA/2J	MGP_DBA2J_G0031764	protein coding gene	Chr7:26246400-26259225 (-)
FVB/NJ	MGP_FVBNJ_G0031721	protein coding gene	Chr7:26314504-26327247 (-)
LP/J	MGP_LPJ_G0031845	protein coding gene	Chr7:27466278-27479157 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031756	protein coding gene	Chr7:28773860-28786804 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032421	protein coding gene	Chr7:26644397-26658407 (-)
PWK/PhJ	MGP_PWKPhJ_G0030706	protein coding gene	Chr7:21247792-21261123 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0030541	protein coding gene	Chr7:17649270-17662511 (-)
WSB/EiJ	MGP_WSBEiJ_G0031090	protein coding gene	Chr7:26973786-26986752 (-)

Human Ortholog

PLEKHG2, pleckstrin homology and RhoGEF domain containing G2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PLEKHG2, pleckstrin homology and RhoGEF domain containing G2
Synonyms

ARHGEF42, CLG, CTB-60E11.4, LDAMD
Links

HGNC:29515

NCBI Gene ID: 64857

neXtProt AC: NX_Q9H7P9

UniProt: Q9H7P9
Chr Location

19q13.2; chr19:39412669-39428415 (+) GRCh38

MGI Vertebrate Homology

Plekhg2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PLEKHG2
Gene Tree

Plekhg2

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

1
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

36 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

6
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

98
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase plekhg2

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All Sequences

85
RefSeq

28
UniProt

8
CCDS

CCDS21040.2, CCDS52162.1

Ensembl

ENSMUSG00000037552 (Evidence)
NCBI Gene

101497

			Length	Strain/Species	Flank
genomic	ENSMUSG00000037552	Ensembl Gene Model \| MGI Sequence Detail	12996	C57BL/6J	± kb
transcript	ENSMUST00000121085	Ensembl \| MGI Sequence Detail	4649	Not Applicable
polypeptide	ENSMUSP00000113449	Ensembl \| MGI Sequence Detail	1365	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000012860 pleckstrin homology domain-containing family G member 2

(term hierarchy)
InterPro Domains

IPR000219 Dbl homology (DH) domain

IPR035899 Dbl homology (DH) domain superfamily

IPR011993 PH-like domain superfamily

IPR043324 PKHG1/2/3, pleckstrin homology (PH) domain

IPR001849 Pleckstrin homology domain
GlyGen

Q6KAU7 1 site, 1 O-linked glycan (1 site)

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All nucleic 98

cDNA 98

Microarray probesets 3

Summaries

All 30

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 6
Earliest

J:74401 Himmel KL, et al., Activation of clg, a novel dbl family guanine nucleotide exchange factor gene, by proviral insertion at evi24, a common integration site in B cell and myeloid leukemias. J Biol Chem. 2002 Apr 19;277(16):13463-72
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Plekhg2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr71488	Chr7:28072082-28072091 (-)	-63 bp
Tssr71487	Chr7:28072055-28072062 (-)	-35 bp
Tssr71486	Chr7:28072022-28072035 (-)	-5 bp
Tssr71485	Chr7:28071988-28072008 (-)	26 bp
Tssr71484	Chr7:28071973-28071982 (-)	46 bp
Tssr71483	Chr7:28071959-28071972 (-)	58 bp
Tssr71482	Chr7:28071935-28071944 (-)	84 bp
Tssr71481	Chr7:28071765-28071796 (-)	243 bp
Tssr71480	Chr7:28067137-28067147 (-)	4,882 bp
Tssr71479	Chr7:28067085-28067090 (-)	4,936 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24