Mapkbp1 MGI Mouse Gene Detail - MGI:1347004 - mitogen-activated protein kinase binding protein 1

Symbol

Mapkbp1
Name

mitogen-activated protein kinase binding protein 1
Synonyms

2810483F24Rik, Jnkbp1

Feature Type

protein coding gene
IDs

MGI:1347004
NCBI Gene: 26390
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr2:119803180-119857889 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 60.03 cM, cytoband E5
Mapping Data

3 experiments

SNPs within 2kb

1077 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1347004	protein coding gene	Chr2:119802868-119857889 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026355	protein coding gene	Chr2:122826983-122882371 (+)
A/J	MGP_AJ_G0026316	protein coding gene	Chr2:117791055-117846003 (+)
AKR/J	MGP_AKRJ_G0026295	protein coding gene	Chr2:121076025-121134190 (+)
BALB/cJ	MGP_BALBcJ_G0026329	protein coding gene	Chr2:118029724-118085217 (+)
C3H/HeJ	MGP_C3HHeJ_G0026075	protein coding gene	Chr2:121543869-121599829 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026776	protein coding gene	Chr2:126831460-126893716 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024156	protein coding gene	Chr2:112810957-112866505 (+)
CAST/EiJ	MGP_CASTEiJ_G0025537	protein coding gene	Chr2:121860558-121917583 (+)
CBA/J	MGP_CBAJ_G0026051	protein coding gene	Chr2:131269176-131326909 (+)
DBA/2J	MGP_DBA2J_G0026190	protein coding gene	Chr2:117180134-117234871 (+)
FVB/NJ	MGP_FVBNJ_G0026152	protein coding gene	Chr2:116014521-116069088 (+)
LP/J	MGP_LPJ_G0026291	protein coding gene	Chr2:123084911-123141094 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026171	protein coding gene	Chr2:135586815-135640790 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026831	protein coding gene	Chr2:121200880-121256354 (+)
PWK/PhJ	MGP_PWKPhJ_G0025273	protein coding gene	Chr2:116776235-116832522 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025072	protein coding gene	Chr2:120393813-120452141 (+)
WSB/EiJ	MGP_WSBEiJ_G0025606	protein coding gene	Chr2:122042078-122098420 (+)

Human Ortholog

MAPKBP1, mitogen-activated protein kinase binding protein 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MAPKBP1, mitogen-activated protein kinase binding protein 1
Synonyms

JNKBP-1, JNKBP1, NPHP20
Links

HGNC:29536

NCBI Gene ID: 23005

neXtProt AC: NX_O60336

UniProt: O60336
Chr Location

15q15.1; chr15:41774434-41827855 (+) GRCh38

MGI Vertebrate Homology

Mapkbp1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MAPKBP1
Gene Tree

Mapkbp1

Diseases

1 with human MAPKBP1 associations

				Human Disease	Mouse Models
				nephronophthisis 20 IDs nephronophthisis 20 DOID:0111127 OMIM:617271

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

1
Radiation induced

1
Targeted

5
Genomic Mutations

2 involving Mapkbp1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

61 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

20
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

890
Tissues

150
cDNA Data

11
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mapkbp1

ZFIN mapkbp1

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All Sequences

57
RefSeq

12
UniProt

4
CCDS

CCDS16612.1, CCDS89541.1

Ensembl

ENSMUSG00000033902 (Evidence)
NCBI Gene

26390

			Length	Strain/Species	Flank
genomic	ENSMUSG00000033902	Ensembl Gene Model \| MGI Sequence Detail	54710	C57BL/6J	± kb
transcript	ENSMUST00000229024	Ensembl \| MGI Sequence Detail	4687	Not Applicable
polypeptide	ENSMUSP00000155163	Ensembl \| MGI Sequence Detail	1509	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000010168 mitogen-activated protein kinase-binding protein 1

(term hierarchy)
InterPro Domains

IPR001680 WD40 repeat

IPR036322 WD40-repeat-containing domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily

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All nucleic 13

cDNA 12

Primer pair 1

Microarray probesets 5

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MGI:1920079, MGI:2139315

Summaries

All 39

Developmental Gene Expression 5

Gene Ontology 5

Phenotypes 11
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Mapkbp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr19673	Chr2:119802862-119802875 (+)	-311 bp
Tssr19674	Chr2:119802876-119802911 (+)	-286 bp
Tssr19675	Chr2:119802916-119802930 (+)	-257 bp
Tssr19676	Chr2:119802936-119802943 (+)	-240 bp
Tssr19677	Chr2:119803210-119803227 (+)	39 bp
Tssr19678	Chr2:119803230-119803241 (+)	56 bp
Tssr19679	Chr2:119843644-119843692 (+)	40,488 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24