Polr3g MGI Mouse Gene Detail - MGI:1914736 - polymerase (RNA) III (DNA directed) polypeptide G

Symbol

Polr3g
Name

polymerase (RNA) III (DNA directed) polypeptide G
Synonyms

2310047G20Rik, RPC32

Feature Type

protein coding gene
IDs

MGI:1914736
NCBI Gene: 67486
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr13:81821962-81859132 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 43.68 cM
Mapping Data

2 experiments

SNPs within 2kb

1307 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914736	protein coding gene	Chr13:81821956-81859132 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020788	protein coding gene	Chr13:82441108-82480180 (-)
A/J	MGP_AJ_G0020744	protein coding gene	Chr13:79568984-79606693 (-)
AKR/J	MGP_AKRJ_G0020717	protein coding gene	Chr13:81923008-81960082 (-)
BALB/cJ	MGP_BALBcJ_G0020740	protein coding gene	Chr13:80112384-80149430 (-)
C3H/HeJ	MGP_C3HHeJ_G0020534	protein coding gene	Chr13:81669597-81707241 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021177	protein coding gene	Chr13:85122277-85159239 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018745	protein coding gene	Chr13:76035461-76075200 (-)
CAST/EiJ	MGP_CASTEiJ_G0020052	protein coding gene	Chr13:80763427-80800208 (-)
CBA/J	MGP_CBAJ_G0020493	protein coding gene	Chr13:88351439-88395746 (-)
DBA/2J	MGP_DBA2J_G0020618	protein coding gene	Chr13:79221538-79258967 (-)
FVB/NJ	MGP_FVBNJ_G0020598	protein coding gene	Chr13:78307223-78344265 (-)
LP/J	MGP_LPJ_G0020691	protein coding gene	Chr13:82663272-82701090 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020627	protein coding gene	Chr13:87261340-87299724 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021217	protein coding gene	Chr13:81340643-81382030 (-)
PWK/PhJ	MGP_PWKPhJ_G0019805	protein coding gene	Chr13:78139140-78174741 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019628	protein coding gene	Chr13:77582724-77620642 (-)
WSB/EiJ	MGP_WSBEiJ_G0020109	protein coding gene	Chr13:81771994-81810763 (-)

Human Ortholog

POLR3G, RNA polymerase III subunit G

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

POLR3G, RNA polymerase III subunit G
Synonyms

C31, RPC32, RPC7
Links

HGNC:30075

NCBI Gene ID: 10622

neXtProt AC: NX_O15318

UniProt: O15318
Chr Location

5q14.3; chr5:90471748-90514557 (+) GRCh38

MGI Vertebrate Homology

Polr3g stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: POLR3G
Gene Tree

Polr3g

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Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
2 phenotypes from multigenic genotypes
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

33
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

24
Targeted

6
Genomic Mutations

1 involving Polr3g
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

40 strains or lines available

Mice homozygous for a null allele exhibit embryonic lethality between E3.5 and E6.5.

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All GO Annotations

21
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

801
Tissues

95
cDNA Data

66
Literature Summary

2

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase polr3g

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All Sequences

38
RefSeq

2
UniProt

1
CCDS

CCDS36738.1

Ensembl

ENSMUSG00000035834 (Evidence)
NCBI Gene

67486

			Length	Strain/Species	Flank
genomic	ENSMUSG00000035834	Ensembl Gene Model \| MGI Sequence Detail	37171	C57BL/6J	± kb
transcript	ENSMUST00000048993	Ensembl \| MGI Sequence Detail	3054	Not Applicable
polypeptide	ENSMUSP00000035289	Ensembl \| MGI Sequence Detail	223	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000013006 DNA-directed RNA polymerase III subunit RPC7

(term hierarchy)
InterPro Domains

IPR024661 DNA-directed RNA polymerase III, subunit Rpc31

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All nucleic 68

cDNA 66

Primer pair 1

Other 1

Microarray probesets 1

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MGI:2145397

Summaries

All 46

Developmental Gene Expression 2

Gene Ontology 7

Phenotypes 17
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Polr3g:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr123322	Chr13:81859420-81859466 (-)	-311 bp
Tssr123321	Chr13:81859403-81859418 (-)	-279 bp
Tssr123320	Chr13:81859056-81859127 (-)	40 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24