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Cfap119 Gene Detail
Summary
  • Symbol
    Cfap119
  • Name
    cilia and flagella associated protein 119
  • Synonyms
    Ccdc189, Gm166, LOC233899
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685012
    NCBI Gene: 233899
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:127182527-127187819 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 69.61 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    182 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685012
 protein coding gene Chr7:127181555-127187819 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033045
 protein coding gene Chr7:131944616-131950828 (-)
A/J MGP_AJ_G0033028
 protein coding gene Chr7:128434545-128440762 (-)
AKR/J MGP_AKRJ_G0032960
 protein coding gene Chr7:131740179-131746390 (-)
BALB/cJ MGP_BALBcJ_G0033029
 protein coding gene Chr7:128080858-128087071 (-)
C3H/HeJ MGP_C3HHeJ_G0032743
 protein coding gene Chr7:131642642-131648855 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033538
 protein coding gene Chr7:137088759-137094971 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030511
 protein coding gene Chr7:129623036-129629430 (-)
CAST/EiJ MGP_CASTEiJ_G0032072
 protein coding gene Chr7:123438291-123444503 (-)
CBA/J MGP_CBAJ_G0032716
 protein coding gene Chr7:141716519-141722731 (-)
DBA/2J MGP_DBA2J_G0032868
 protein coding gene Chr7:126408533-126414745 (-)
FVB/NJ MGP_FVBNJ_G0032821
 protein coding gene Chr7:126255076-126261288 (-)
LP/J MGP_LPJ_G0032962
 protein coding gene Chr7:133424637-133430849 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032853
 protein coding gene Chr7:142832452-142838669 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033558
 protein coding gene Chr7:130735505-130741718 (-)
PWK/PhJ MGP_PWKPhJ_G0031779
 protein coding gene Chr7:119417907-119424199 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031625
 protein coding gene Chr7:117544670-117550900 (-)
WSB/EiJ MGP_WSBEiJ_G0032184
 protein coding gene Chr7:131702335-131708552 (-)



Homology
more
  • Human Ortholog
    CFAP119, cilia and flagella associated protein 119
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CFAP119, cilia and flagella associated protein 119
  • Synonyms
    C16orf93, CCDC189
  • Links
    NCBI Gene ID: 90835
    neXtProt AC: NX_A1A4V9
    UniProt: A1A4V9

  • Chr Location
    16p11.2; chr16:30757423-30762221 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 3 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit male infertility, decreased testis size and weight, oligozoospermia, asthenozoospermia, and teratozoospermia with abnormal sperm head morphology and multiple morphological abnormalities of the sperm flagella.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    836
  • Tissues
    16
  • cDNA Data
    18
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 233899 NCBI Gene Model | MGI Sequence Detail 5293 C57BL/6J ±  kb
    transcript NR_175799 RefSeq | MGI Sequence Detail 1158 C57BL/6  
    polypeptide Q6NZQ0 UniProt | EBI | MGI Sequence Detail 333 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 18

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:7413980
    References
    more
    • Summaries
      All 31
      Developmental Gene Expression 2
      Gene Ontology 3
      Phenotypes 9
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/22/2024
    MGI 6.24     		The Jackson Laboratory