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Zmiz1 Gene Detail
Summary
  • Symbol
    Zmiz1
  • Name
    zinc finger, MIZ-type containing 1
  • Synonyms
    Rai17, Zimp10
  • Feature Type
    protein coding gene
  • IDs
    MGI:3040693
    NCBI Gene: 328365
  • Alliance
    gene page
  • Transcription Start Sites
    41 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:25459609-25667167 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 15.03 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    4573 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3040693
 protein coding gene Chr14:25458299-25667167 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021065
 protein coding gene Chr14:18387201-18597766 (+)
A/J MGP_AJ_G0021014
 protein coding gene Chr14:17931790-18143268 (+)
AKR/J MGP_AKRJ_G0020991
 protein coding gene Chr14:18567916-18779163 (+)
BALB/cJ MGP_BALBcJ_G0021017
 protein coding gene Chr14:18034110-18245159 (+)
C3H/HeJ MGP_C3HHeJ_G0020801
 protein coding gene Chr14:18490242-18700216 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021450
 protein coding gene Chr14:18958774-19171810 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019018
 protein coding gene Chr14:18136518-18342578 (+)
CAST/EiJ MGP_CASTEiJ_G0020325
 protein coding gene Chr14:18369522-18577153 (+)
CBA/J MGP_CBAJ_G0020767
 protein coding gene Chr14:19890289-20112101 (+)
DBA/2J MGP_DBA2J_G0020890
 protein coding gene Chr14:17736551-17944677 (+)
FVB/NJ MGP_FVBNJ_G0020873
 protein coding gene Chr14:17610386-17824857 (+)
LP/J MGP_LPJ_G0020966
 protein coding gene Chr14:18664642-18876885 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020899
 protein coding gene Chr14:19589325-19804596 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021483
 protein coding gene Chr14:18364589-18577563 (+)
PWK/PhJ MGP_PWKPhJ_G0020074
 protein coding gene Chr14:17354671-17566823 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019896
 protein coding gene Chr14:18201351-18406874 (+)
WSB/EiJ MGP_WSBEiJ_G0020381
 protein coding gene Chr14:18356423-18568266 (+)



Homology
more
  • Human Ortholog
    ZMIZ1, zinc finger MIZ-type containing 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZMIZ1, zinc finger MIZ-type containing 1
  • Synonyms
    MIZ, NEDDFSA, RAI17, TRAFIP10, ZIMP10
  • Links
    NCBI Gene ID: 57178
    neXtProt AC: NX_Q9ULJ6
    UniProt: Q9ULJ6

  • Chr Location
    10q22.3; chr10:79068966-79316519 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 2 alleles in 3 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display embryonic lethality during organogenesis with failure of yolk sac vascular remodeling and abnormal embryonic vascular development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    842
  • Tissues
    76
  • cDNA Data
    19
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000007817 Ensembl Gene Model | MGI Sequence Detail 207559 C57BL/6J ±  kb
    transcript ENSMUST00000162645 Ensembl | MGI Sequence Detail 7482 Not Applicable  
    polypeptide ENSMUSP00000124863 Ensembl | MGI Sequence Detail 1072 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 19
      Primer pair 2
      Other 1

      Microarray probesets 9
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 11
      Gene Ontology 9
      Phenotypes 15
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:356248 K C R, et al., Zmiz1 is a novel regulator of brain development associated with autism and intellectual disability. Front Psychiatry. 2024;15:1375492
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory