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Inpp4b Gene Detail
Summary
  • Symbol
    Inpp4b
  • Name
    inositol polyphosphate-4-phosphatase, type II
  • Synonyms
    E130107I17Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2158925
    NCBI Gene: 234515
  • Alliance
    gene page
  • Transcription Start Sites
    49 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:82069185-82854543 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 39.02 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    22526 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2158925
 protein coding gene Chr8:82068895-82865553 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033822
 protein coding gene Chr8:82097770-82896137 (+)
A/J MGP_AJ_G0033805
 protein coding gene Chr8:78845057-79647343 (+)
AKR/J MGP_AKRJ_G0033731
 protein coding gene Chr8:81187169-81991366 (+)
BALB/cJ MGP_BALBcJ_G0033798
 protein coding gene Chr8:78959544-79751578 (+)
C3H/HeJ MGP_C3HHeJ_G0033507
 protein coding gene Chr8:81822004-82637074 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034318
 protein coding gene Chr8:85255759-86102348 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031259
 protein coding gene Chr8:72809185-73554612 (+)
CAST/EiJ MGP_CASTEiJ_G0032838
 protein coding gene Chr8:81195187-82024554 (+)
CBA/J MGP_CBAJ_G0033486
 protein coding gene Chr8:88286291-89143376 (+)
DBA/2J MGP_DBA2J_G0033639
 protein coding gene Chr8:78531019-79315258 (+)
FVB/NJ MGP_FVBNJ_G0033584
 protein coding gene Chr8:77454061-78233811 (+)
LP/J MGP_LPJ_G0033729
 protein coding gene Chr8:82168046-83015508 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033627
 protein coding gene Chr8:90730229-91686294 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034335
 protein coding gene Chr8:81206557-82009641 (+)
PWK/PhJ MGP_PWKPhJ_G0032541
 protein coding gene Chr8:77764685-78532811 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032379
 protein coding gene Chr8:79982172-80783146 (+)
WSB/EiJ MGP_WSBEiJ_G0032951
 protein coding gene Chr8:81553371-82381648 (+)



Homology
more
  • Human Ortholog
    INPP4B, inositol polyphosphate-4-phosphatase type II B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    INPP4B, inositol polyphosphate-4-phosphatase type II B
  • Links
    NCBI Gene ID: 8821
    neXtProt AC: NX_O15327
    UniProt: O15327

  • Chr Location
    4q31.21; chr4:142023160-142847432 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 1 allele in 1 genetic background
    47 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit osteoporosis, reduced long bone length, increased osteoclast numbers and size, increased osteoblast numbers, and increased bone resorption and resorption.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    879
  • Tissues
    109
  • cDNA Data
    22
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037940 Ensembl Gene Model | MGI Sequence Detail 785359 C57BL/6J ±  kb
    transcript ENSMUST00000109852 Ensembl | MGI Sequence Detail 4095 Not Applicable  
    polypeptide ENSMUSP00000105478 Ensembl | MGI Sequence Detail 941 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 22

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2444740
    References
    more
    • Summaries
      All 79
      Developmental Gene Expression 4
      Gene Ontology 9
      Phenotypes 47
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
    • Latest
      J:352007 Peng V, et al., Inositol phosphatase INPP4B sustains ILC1s and intratumoral NK cells through an AKT-driven pathway. J Exp Med. 2024 Mar 4;221(3)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory