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Mpp4 Gene Detail
Summary
  • Symbol
    Mpp4
  • Name
    membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
  • Synonyms
    DLG6
  • Feature Type
    protein coding gene
  • IDs
    MGI:2386681
    NCBI Gene: 227157
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:59160094-59202548 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 29.20 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1394 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2386681
 protein coding gene Chr1:59160094-59202548 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016063
 protein coding gene Chr1:59069196-59111700 (-)
A/J MGP_AJ_G0016046
 protein coding gene Chr1:57014836-57057685 (-)
AKR/J MGP_AKRJ_G0016002
 protein coding gene Chr1:58611662-58654750 (-)
BALB/cJ MGP_BALBcJ_G0016001
 protein coding gene Chr1:57057648-57099537 (-)
C3H/HeJ MGP_C3HHeJ_G0015833
 protein coding gene Chr1:58858563-58900680 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016454
 protein coding gene Chr1:61403105-61448956 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014175
 protein coding gene Chr1:52838801-52883283 (-)
CAST/EiJ MGP_CASTEiJ_G0015415
 protein coding gene Chr1:57996453-58039888 (-)
CBA/J MGP_CBAJ_G0015805
 protein coding gene Chr1:63318212-63364632 (-)
DBA/2J MGP_DBA2J_G0015906
 protein coding gene Chr1:56440003-56481884 (-)
FVB/NJ MGP_FVBNJ_G0015908
 protein coding gene Chr1:55743584-55787431 (-)
LP/J MGP_LPJ_G0015978
 protein coding gene Chr1:59950352-59991600 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015928
 protein coding gene Chr1:66256300-66299811 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016501
 protein coding gene Chr1:58520816-58563156 (-)
PWK/PhJ MGP_PWKPhJ_G0015202
 protein coding gene Chr1:55780620-55822969 (-)
SPRET/EiJ MGP_SPRETEiJ_G0014982
 protein coding gene Chr1:58045931-58087532 (-)
WSB/EiJ MGP_WSBEiJ_G0015478
 protein coding gene Chr1:58223990-58267013 (-)



Homology
more
  • Human Ortholog
    MPP4, MAGUK p55 scaffold protein 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MPP4, MAGUK p55 scaffold protein 4
  • Synonyms
    ALS2CR5, DLG6
  • Links
    NCBI Gene ID: 58538
    neXtProt AC: NX_Q96JB8
    UniProt: Q96JB8

  • Chr Location
    2q33.1; chr2:201644870-201698694 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for mutations display sporadic photorecptor displacement. Correct protein localization at the presynaptic photoreceptor membrane.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    729
  • Tissues
    15
  • cDNA Data
    12
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 227157 NCBI Gene Model | MGI Sequence Detail 42455 C57BL/6J ±  kb
    transcript NM_001164682 RefSeq | MGI Sequence Detail 2982 C57BL/6  
    polypeptide Q6P7F1 UniProt | EBI | MGI Sequence Detail 635 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 13
      Primer pair 2

      Microarray probesets 2
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 5
      Gene Ontology 5
      Phenotypes 10
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:231433 Xiao J, et al., Motor phenotypes and molecular networks associated with germline deficiency of Ciz1. Exp Neurol. 2016 Sep;283(Pt A):110-20
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory