Snx6 MGI Mouse Gene Detail - MGI:1919433

Symbol

Snx6
Name

sorting nexin 6
Synonyms

2010006G21Rik, 2610032J07Rik, 2810425K19Rik

Feature Type

protein coding gene
IDs

MGI:1919433
NCBI Gene: 72183
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr12:54793124-54842464 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 23.46 cM
Mapping Data

2 experiments

SNPs within 2kb

1178 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919433	protein coding gene	Chr12:54793124-54842488 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019738	protein coding gene	Chr12:53691683-53738997 (-)
A/J	MGP_AJ_G0019700	protein coding gene	Chr12:51804449-51848105 (-)
AKR/J	MGP_AKRJ_G0019671	protein coding gene	Chr12:53351083-53392973 (-)
BALB/cJ	MGP_BALBcJ_G0019678	protein coding gene	Chr12:52087858-52128838 (-)
C3H/HeJ	MGP_C3HHeJ_G0019481	protein coding gene	Chr12:53461556-53505744 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020126	protein coding gene	Chr12:55356247-55402112 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017749	protein coding gene	Chr12:50072376-50113588 (-)
CAST/EiJ	MGP_CASTEiJ_G0019034	protein coding gene	Chr12:48470281-48511461 (-)
CBA/J	MGP_CBAJ_G0019453	protein coding gene	Chr12:57244017-57291416 (-)
DBA/2J	MGP_DBA2J_G0019567	protein coding gene	Chr12:51646127-51701653 (-)
FVB/NJ	MGP_FVBNJ_G0019556	protein coding gene	Chr12:51066218-51110767 (-)
LP/J	MGP_LPJ_G0019639	protein coding gene	Chr12:53754519-53801609 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019592	protein coding gene	Chr12:58844120-58902525 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020164	protein coding gene	Chr12:52838313-52890448 (-)
PWK/PhJ	MGP_PWKPhJ_G0018801	protein coding gene	Chr12:46221891-46265040 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018595	protein coding gene	Chr12:47429166-47474699 (-)
WSB/EiJ	MGP_WSBEiJ_G0019085	protein coding gene	Chr12:53316757-53360298 (-)

Human Ortholog

SNX6, sorting nexin 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SNX6, sorting nexin 6
Synonyms

MSTP010, TFAF2
Links

HGNC:14970

NCBI Gene ID: 58533

neXtProt AC: NX_Q9UNH7

UniProt: Q9UNH7
Chr Location

14q13.1; chr14:34561093-34630160 (-) GRCh38

MGI Vertebrate Homology

Snx6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SNX6
Protein SuperFamily

Snx5_Snx6
Gene Tree

Snx6

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Phenotype Summary

12 phenotypes from 2 alleles in 2 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

64
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

58
Targeted

3
Genomic Mutations

1 involving Snx6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

62 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a conditional allele activated in neurons exhibit impaired spatial learning and memory, decreased dendritic spine density in CA1 neurons, and reduced AMPA-mediated eEPSCs.

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All GO Annotations

41
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

709
Tissues

3
cDNA Data

9
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase snx6

ZFIN snx6

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All Sequences

53
RefSeq

4
UniProt

4
CCDS

CCDS36447.1

Ensembl

ENSMUSG00000005656 (Evidence)
NCBI Gene

72183

			Length	Strain/Species	Flank
genomic	72183	NCBI Gene Model \| MGI Sequence Detail	49341	C57BL/6J	± kb
transcript	NM_026998	RefSeq \| MGI Sequence Detail	1914	C57BL/6
polypeptide	Q6P8X1	UniProt \| EBI \| MGI Sequence Detail	406	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000015385 sorting nexin-6

(term hierarchy)
InterPro Domains

IPR027267 AH/BAR domain superfamily

IPR001683 Phox homology

IPR036871 PX domain superfamily

IPR042136 SNX6, PX domain

IPR014637 Sorting nexin-5/6/32

IPR028657 Sorting nexin-6, BAR domain

IPR015404 Sorting nexin/Vps5-like, C-terminal
GlyGen

Q6P8X1 1 site, 1 O-linked glycan (1 site)

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All nucleic 11

cDNA 10

Primer pair 1

Microarray probesets 7

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MGI:1916480, MGI:1917093, MGI:2144946, MGI:2145122

Summaries

All 44

Developmental Gene Expression 2

Gene Ontology 10

Phenotypes 13
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Snx6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr116309	Chr12:54842502-54842509 (-)	-42 bp
Tssr116308	Chr12:54842483-54842499 (-)	-27 bp
Tssr116307	Chr12:54842445-54842481 (-)	1 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24