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Fhod1 Gene Detail
Summary
  • Symbol
    Fhod1
  • Name
    formin homology 2 domain containing 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2679008
    NCBI Gene: 234686
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:106055795-106074585 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 53.04 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    422 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2679008
 protein coding gene Chr8:106055792-106074650 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034041
 protein coding gene Chr8:107601475-107621838 (-)
A/J MGP_AJ_G0034022
 protein coding gene Chr8:103307570-103326351 (-)
AKR/J MGP_AKRJ_G0033948
 protein coding gene Chr8:106292044-106310653 (-)
BALB/cJ MGP_BALBcJ_G0034015
 protein coding gene Chr8:103483135-103501864 (-)
C3H/HeJ MGP_C3HHeJ_G0033727
 protein coding gene Chr8:107043208-107061809 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034535
 protein coding gene Chr8:111548094-111566872 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031477
 protein coding gene Chr8:96457002-96475573 (-)
CAST/EiJ MGP_CASTEiJ_G0033053
 protein coding gene Chr8:106538080-106557892 (-)
CBA/J MGP_CBAJ_G0033700
 protein coding gene Chr8:115146968-115175266 (-)
DBA/2J MGP_DBA2J_G0033855
 protein coding gene Chr8:102652255-102671465 (-)
FVB/NJ MGP_FVBNJ_G0033801
 protein coding gene Chr8:101576402-101595322 (-)
LP/J MGP_LPJ_G0033946
 protein coding gene Chr8:107804435-107825718 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033844
 protein coding gene Chr8:118357749-118379090 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034553
 protein coding gene Chr8:106265868-106287832 (-)
PWK/PhJ MGP_PWKPhJ_G0032754
 protein coding gene Chr8:102039335-102059064 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032595
 protein coding gene Chr8:104941455-104961602 (-)
WSB/EiJ MGP_WSBEiJ_G0033169
 protein coding gene Chr8:106918457-106940110 (-)



Homology
more
  • Human Ortholog
    FHOD1, formin homology 2 domain containing 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FHOD1, formin homology 2 domain containing 1
  • Synonyms
    FHOS
  • Links
    NCBI Gene ID: 29109
    neXtProt AC: NX_Q9Y613
    UniProt: Q9Y613

  • Chr Location
    16q22.1; chr16:67229387-67247481 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit normal developed and morphology with normal cardiac development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    902
  • Tissues
    61
  • cDNA Data
    28
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000014778 Ensembl Gene Model | MGI Sequence Detail 18791 C57BL/6J ±  kb
    transcript ENSMUST00000014922 Ensembl | MGI Sequence Detail 3928 Not Applicable  
    polypeptide ENSMUSP00000014922 Ensembl | MGI Sequence Detail 1197 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000007516 FH1/FH2 domain-containing protein 1
      (term hierarchy)
    • InterPro Domains
      IPR011989 Armadillo-like helical
      IPR016024 Armadillo-type fold
      IPR041387 FHOD1, N-terminal GTPase-binding domain
      IPR015425 Formin, FH2 domain
      IPR042201 Formin, FH2 domain superfamily
      IPR014768 Rho GTPase-binding/formin homology 3 (GBD/FH3) domain
    • GlyGen
      Q6P9Q4 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 30
      cDNA 28
      Primer pair 2

      Microarray probesets 2
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 5
      Gene Ontology 8
      Phenotypes 8
    • Earliest
      J:21932 Lake S, et al., Cloning of the rat and human prostaglandin F2 alpha receptors and the expression of the rat prostaglandin F2 alpha receptor. FEBS Lett. 1994 Dec 5;355(3):317-25
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory