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Galnt2 Gene Detail
Summary
  • Symbol
    Galnt2
  • Name
    polypeptide N-acetylgalactosaminyltransferase 2
  • Synonyms
    ppGaNTase-T2
  • Feature Type
    protein coding gene
  • IDs
    MGI:894694
    NCBI Gene: 108148
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:124958133-125072461 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 72.52 cM, cytoband E2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3678 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_894694
 protein coding gene Chr8:124958130-125072463 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034269
 protein coding gene Chr8:127902231-128021597 (+)
A/J MGP_AJ_G0034249
 protein coding gene Chr8:122611518-122728048 (+)
AKR/J MGP_AKRJ_G0034176
 protein coding gene Chr8:126137776-126254356 (+)
BALB/cJ MGP_BALBcJ_G0034242
 protein coding gene Chr8:122794608-122910759 (+)
C3H/HeJ MGP_C3HHeJ_G0033953
 protein coding gene Chr8:126769887-126891475 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034762
 protein coding gene Chr8:132193794-132311714 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031703
 protein coding gene Chr8:115381013-115498986 (+)
CAST/EiJ MGP_CASTEiJ_G0033280
 protein coding gene Chr8:126891003-127008348 (+)
CBA/J MGP_CBAJ_G0033926
 protein coding gene Chr8:137032198-137149711 (+)
DBA/2J MGP_DBA2J_G0034082
 protein coding gene Chr8:121772014-121885980 (+)
FVB/NJ MGP_FVBNJ_G0034026
 protein coding gene Chr8:120932038-121049987 (+)
LP/J MGP_LPJ_G0034171
 protein coding gene Chr8:128061354-128177725 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034073
 protein coding gene Chr8:139141892-139257205 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034781
 protein coding gene Chr8:126375938-126490079 (+)
PWK/PhJ MGP_PWKPhJ_G0032982
 protein coding gene Chr8:121528039-121644725 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032821
 protein coding gene Chr8:125014388-125145523 (+)
WSB/EiJ MGP_WSBEiJ_G0033397
 protein coding gene Chr8:127097937-127213174 (+)



Homology
more
  • Human Ortholog
    GALNT2, polypeptide N-acetylgalactosaminyltransferase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GALNT2, polypeptide N-acetylgalactosaminyltransferase 2
  • Synonyms
    CDG2T, GalNAc-T2
  • Links
    NCBI Gene ID: 2590
    neXtProt AC: NX_Q10471
    UniProt: Q10471

  • Chr Location
    1q42.13; chr1:230057789-230282122 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human GALNT2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased circulating HDL cholesterol levels under both chow- and Western diet-fed conditions, a marked elevation in fasting triglyceride levels, and delayed postprandial triglyceride clearance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    740
  • Tissues
    31
  • cDNA Data
    180
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 108148 NCBI Gene Model | MGI Sequence Detail 114329 C57BL/6J ±  kb
    transcript NM_139272 RefSeq | MGI Sequence Detail 4131 Not Specified  
    polypeptide Q6PB93 UniProt | EBI | MGI Sequence Detail 570 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 183
      cDNA 180
      Primer pair 3

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2142569
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 6
      Gene Ontology 7
      Phenotypes 11
    • Earliest
      J:40489 Hagen FK, et al., cDNA cloning and expression of a novel UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase. J Biol Chem. 1997 May 23;272(21):13843-8
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory