Dlgap3 MGI Mouse Gene Detail - MGI:3039563

Symbol

Dlgap3
Name

DLG associated protein 3
Synonyms

DAP3, Prpl8, PSD-95/SAP90-binding protein 3, SAP90/PSD 95 associated protein 3, Sapap3

Feature Type

protein coding gene
IDs

MGI:3039563
NCBI Gene: 242667
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr4:127062997-127130815 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 61.33 cM
Mapping Data

4 experiments

SNPs within 2kb

1624 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3039563	protein coding gene	Chr4:127062090-127130815 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028794	protein coding gene	Chr4:128906907-128979805 (+)
A/J	MGP_AJ_G0028753	protein coding gene	Chr4:123823267-123895417 (+)
AKR/J	MGP_AKRJ_G0028706	protein coding gene	Chr4:127224066-127303023 (+)
BALB/cJ	MGP_BALBcJ_G0028776	protein coding gene	Chr4:124390987-124459895 (+)
C3H/HeJ	MGP_C3HHeJ_G0028490	protein coding gene	Chr4:127301206-127372860 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029218	protein coding gene	Chr4:133812226-133889356 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026491	protein coding gene	Chr4:116946264-117013924 (+)
CAST/EiJ	MGP_CASTEiJ_G0027923	protein coding gene	Chr4:125424048-125497644 (+)
CBA/J	MGP_CBAJ_G0028456	protein coding gene	Chr4:137068091-137160409 (+)
DBA/2J	MGP_DBA2J_G0028605	protein coding gene	Chr4:124267048-124335937 (+)
FVB/NJ	MGP_FVBNJ_G0028572	protein coding gene	Chr4:122930200-122997201 (+)
LP/J	MGP_LPJ_G0028706	protein coding gene	Chr4:129193413-129270389 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028598	protein coding gene	Chr4:142067198-142139172 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029256	protein coding gene	Chr4:127602082-127674971 (+)
PWK/PhJ	MGP_PWKPhJ_G0027644	protein coding gene	Chr4:120771448-120846865 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027471	protein coding gene	Chr4:123418113-123490214 (+)
WSB/EiJ	MGP_WSBEiJ_G0028003	protein coding gene	Chr4:127709108-127782027 (+)

Human Ortholog

DLGAP3, DLG associated protein 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DLGAP3, DLG associated protein 3
Synonyms

DAP3, SAPAP3, SPAPA3
Links

HGNC:30368

NCBI Gene ID: 58512

neXtProt AC: NX_O95886

UniProt: O95886
Chr Location

1p34.3; chr1:34865436-34929650 (-) GRCh38

MGI Vertebrate Homology

Dlgap3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DLGAP3
Gene Tree

Dlgap3

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
45 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

49
Chemically induced (other)

2
Endonuclease-mediated

2
Gene trapped

37
Radiation induced

1
Targeted

7
Genomic Mutations

4 involving Dlgap3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

84 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit skin lesions associated with excessive grooming, increased anxiety-related behaviors, altered synaptic transmission and abnormal sleep patterns.

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All GO Annotations

32
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

712
Tissues

1
cDNA Data

28
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dlgap3

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All Sequences

57
RefSeq

18
UniProt

3
CCDS

CCDS18665.1

Ensembl

ENSMUSG00000042388 (Evidence)
NCBI Gene

242667

			Length	Strain/Species	Flank
genomic	ENSMUSG00000042388	Ensembl Gene Model \| MGI Sequence Detail	67819	C57BL/6J	± kb
transcript	ENSMUST00000106094	Ensembl \| MGI Sequence Detail	4207	Not Applicable
polypeptide	ENSMUSP00000101700	Ensembl \| MGI Sequence Detail	977	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000006518 disks large-associated protein 3

(term hierarchy)
PDB

5IZU
InterPro Domains

IPR005026 SAPAP family
GlyGen

Q6PFD5 6 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (5 sites)

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All nucleic 28

cDNA 28

Microarray probesets 4

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MGI:892992

Summaries

All 76

Developmental Gene Expression 2

Gene Ontology 7

Phenotypes 45
Earliest

J:39869 Yehiely F, et al., Identification of candidate proteins binding to prion protein. Neurobiol Dis. 1997;3(4):339-55
Latest

J:358787 Mondragon-Gonzalez SL, et al., Closed-loop recruitment of striatal interneurons prevents compulsive-like grooming behaviors. Nat Neurosci. 2024 Jun;27(6):1148-1156

TSS for Dlgap3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr39050	Chr4:127062551-127062572 (+)	-435 bp
Tssr39051	Chr4:127062749-127062762 (+)	-241 bp
Tssr39052	Chr4:127062924-127063023 (+)	-23 bp
Tssr39053	Chr4:127066659-127066691 (+)	3,678 bp
Tssr39054	Chr4:127067013-127067026 (+)	4,023 bp
Tssr39055	Chr4:127089024-127089055 (+)	26,043 bp
Tssr39056	Chr4:127102084-127102096 (+)	39,093 bp
Tssr39057	Chr4:127104100-127104122 (+)	41,114 bp
Tssr39058	Chr4:127108538-127108570 (+)	45,557 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24