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Tmeff1 Gene Detail
Summary
  • Symbol
    Tmeff1
  • Name
    transmembrane protein with EGF-like and two follistatin-like domains 1
  • Synonyms
    M7365, tomoregulin-like
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926810
    NCBI Gene: 230157
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:48585174-48663131 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 26.15 cM, cytoband B2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2264 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926810
 protein coding gene Chr4:48585064-48663136 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028276
 protein coding gene Chr4:47012137-47094079 (+)
A/J MGP_AJ_G0028236
 protein coding gene Chr4:45269997-45350419 (+)
AKR/J MGP_AKRJ_G0028185
 protein coding gene Chr4:46435133-46517095 (+)
BALB/cJ MGP_BALBcJ_G0028255
 protein coding gene Chr4:45377999-45459007 (+)
C3H/HeJ MGP_C3HHeJ_G0027976
 protein coding gene Chr4:46990135-47076242 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028696
 protein coding gene Chr4:48708329-48803510 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026005
 protein coding gene Chr4:42607775-42686022 (+)
CAST/EiJ MGP_CASTEiJ_G0027415
 protein coding gene Chr4:46590011-46665675 (+)
CBA/J MGP_CBAJ_G0027942
 protein coding gene Chr4:50289295-50376384 (+)
DBA/2J MGP_DBA2J_G0028092
 protein coding gene Chr4:45147871-45227187 (+)
FVB/NJ MGP_FVBNJ_G0028059
 protein coding gene Chr4:44411338-44491615 (+)
LP/J MGP_LPJ_G0028191
 protein coding gene Chr4:47074137-47153871 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028083
 protein coding gene Chr4:53291494-53377254 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028731
 protein coding gene Chr4:46620778-46700663 (+)
PWK/PhJ MGP_PWKPhJ_G0027140
 protein coding gene Chr4:45277351-45360968 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026968
 protein coding gene Chr4:46135444-46217189 (+)
WSB/EiJ MGP_WSBEiJ_G0027493
 protein coding gene Chr4:46554849-46636862 (+)



Homology
more
  • Human Ortholog
    MSANTD3-TMEFF1, MSANTD3-TMEFF1 readthrough
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MSANTD3-TMEFF1, MSANTD3-TMEFF1 readthrough
  • Synonyms
    C9orf2, C9orf30-TMEFF1, C9orf3-TMEFF1, H7365, TMEFF1, TR-1
  • Links
    NCBI Gene ID: 100526694
    neXtProt AC: NX_Q8IYR6

  • Chr Location
    9q31.1; chr9:100441906-100577636 (+)  GRCh38
  • Human Ortholog
    TMEFF1, transmembrane protein with EGF like and two follistatin like domains 1
  • Synonyms
    C9orf2, CT120.1, H7365, TR-1
  • Links
    NCBI Gene ID: 8577
    neXtProt AC: NX_Q8IYR6
    UniProt: Q8IYR6

  • Chr Location
    9q31.1; chr9:100473149-100577636 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    882
  • Tissues
    164
  • cDNA Data
    13
  • Literature Summary
    8
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000028347 Ensembl Gene Model | MGI Sequence Detail 77958 C57BL/6J ±  kb
transcript ENSMUST00000030032 Ensembl | MGI Sequence Detail 2461 Not Applicable  
polypeptide ENSMUSP00000030032 Ensembl | MGI Sequence Detail 372 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    cDNA 14
    Primer pair 2
    Other 1

    Microarray probesets 5
References
more
  • Summaries
    All 38
    Developmental Gene Expression 8
    Gene Ontology 4
    Phenotypes 9
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
  • Latest
    J:354579 Dai Y, et al., TMEFF1 is a neuron-specific restriction factor for herpes simplex virus. Nature. 2024 Aug;632(8024):383-389
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory