Bend6 MGI Mouse Gene Detail - MGI:2444572

Symbol

Bend6
Name

BEN domain containing 6
Synonyms

B230209C24Rik

Feature Type

protein coding gene
IDs

MGI:2444572
NCBI Gene: 320705
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr1:33891133-33946897 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 12.85 cM
Mapping Data

1 experiment

SNPs within 2kb

2263 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2444572	protein coding gene	Chr1:33891133-33946925 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0015905	protein coding gene	Chr1:32226980-32282493 (-)
A/J	MGP_AJ_G0015889	protein coding gene	Chr1:31457371-31513112 (-)
AKR/J	MGP_AKRJ_G0015845	protein coding gene	Chr1:31816783-31872276 (-)
BALB/cJ	MGP_BALBcJ_G0015843	protein coding gene	Chr1:31094085-31149698 (-)
C3H/HeJ	MGP_C3HHeJ_G0015677	protein coding gene	Chr1:32025251-32081040 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0016296	protein coding gene	Chr1:33703221-33758863 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014018	protein coding gene	Chr1:28631144-28689842 (-)
CAST/EiJ	MGP_CASTEiJ_G0015257	protein coding gene	Chr1:31861550-31924572 (-)
CBA/J	MGP_CBAJ_G0015648	protein coding gene	Chr1:34624832-34680491 (-)
DBA/2J	MGP_DBA2J_G0015749	protein coding gene	Chr1:30782204-30839935 (-)
FVB/NJ	MGP_FVBNJ_G0015751	protein coding gene	Chr1:30327260-30383387 (-)
LP/J	MGP_LPJ_G0015819	protein coding gene	Chr1:32569778-32625362 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015771	protein coding gene	Chr1:36912748-36970304 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016343	protein coding gene	Chr1:31799239-31857458 (-)
PWK/PhJ	MGP_PWKPhJ_G0015040	protein coding gene	Chr1:30505469-30565347 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0014823	protein coding gene	Chr1:31783311-31838919 (-)
WSB/EiJ	MGP_WSBEiJ_G0015319	protein coding gene	Chr1:31788221-31846149 (-)

Human Ortholog

BEND6, BEN domain containing 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BEND6, BEN domain containing 6
Synonyms

C6orf65
Links

HGNC:20871

NCBI Gene ID: 221336

neXtProt AC: NX_Q5SZJ8

UniProt: Q5SZJ8
Chr Location

6p12.1; chr6:56955107-57027346 (+) GRCh38

MGI Vertebrate Homology

Bend6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: BEND6
Gene Tree

Bend6

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

5
Targeted

2
Genomic Mutations

1 involving Bend6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

15 strains or lines available

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All GO Annotations

14
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

721
Tissues

12
cDNA Data

16
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas

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All Sequences

48
RefSeq

6
UniProt

2
CCDS

CCDS35533.1, CCDS78557.1

Ensembl

ENSMUSG00000042182 (Evidence)
NCBI Gene

320705

			Length	Strain/Species	Flank
genomic	ENSMUSG00000042182	Ensembl Gene Model \| MGI Sequence Detail	55765	C57BL/6J	± kb
transcript	ENSMUST00000062289	Ensembl \| MGI Sequence Detail	2487	Not Applicable
polypeptide	ENSMUSP00000052919	Ensembl \| MGI Sequence Detail	281	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000032301 BEN domain-containing protein 6

(term hierarchy)
InterPro Domains

IPR018379 BEN domain

IPR037496 BEN domain-containing protein 6-like
GlyGen

Q6PFX2 1 site, 1 N-linked glycan (1 site)

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All nucleic 17

cDNA 16

Primer pair 1

Microarray probesets 3

Summaries

All 34

Developmental Gene Expression 3

Gene Ontology 7

Phenotypes 9
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Bend6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr11214	Chr1:33946930-33946941 (-)	-39 bp
Tssr11213	Chr1:33946907-33946918 (-)	-16 bp
Tssr11212	Chr1:33946802-33946890 (-)	51 bp
Tssr11211	Chr1:33946780-33946791 (-)	111 bp
Tssr11210	Chr1:33946762-33946772 (-)	130 bp
Tssr11209	Chr1:33926676-33926679 (-)	20,219 bp
Tssr11208	Chr1:33903744-33903760 (-)	43,145 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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