Inca1 MGI Mouse Gene Detail - MGI:2144284 - inhibitor of CDK, cyclin A1 interacting protein 1

Symbol

Inca1
Name

inhibitor of CDK, cyclin A1 interacting protein 1

Feature Type

protein coding gene
IDs

MGI:2144284
NCBI Gene: 103844
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr11:70579187-70590981 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 43.21 cM
Mapping Data

1 experiment

SNPs within 2kb

110 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2144284	protein coding gene	Chr11:70579187-70593177 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018613	protein coding gene	Chr11:71235731-71250901 (-)
A/J	MGP_AJ_G0018581	protein coding gene	Chr11:68542910-68557174 (-)
AKR/J	MGP_AKRJ_G0018550	protein coding gene	Chr11:70601389-70613034 (-)
BALB/cJ	MGP_BALBcJ_G0018553	protein coding gene	Chr11:68852096-68864320 (-)
C3H/HeJ	MGP_C3HHeJ_G0018366	protein coding gene	Chr11:70619258-70634450 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019004	protein coding gene	Chr11:73393283-73406402 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016649	protein coding gene	Chr11:65450211-65460937 (-)
CAST/EiJ	MGP_CASTEiJ_G0017921	protein coding gene	Chr11:70892743-70905687 (-)
CBA/J	MGP_CBAJ_G0018338	protein coding gene	Chr11:76695779-76711106 (-)
DBA/2J	MGP_DBA2J_G0018448	protein coding gene	Chr11:68116151-68127795 (-)
FVB/NJ	MGP_FVBNJ_G0018438	protein coding gene	Chr11:67757939-67769537 (-)
LP/J	MGP_LPJ_G0018518	protein coding gene	Chr11:71813875-71827777 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018461	protein coding gene	Chr11:77247464-77260719 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019046	protein coding gene	Chr11:70858965-70872058 (-)
PWK/PhJ	MGP_PWKPhJ_G0017695	protein coding gene	Chr11:68763458-68775506 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017485	protein coding gene	Chr11:70677125-70688728 (-)
WSB/EiJ	MGP_WSBEiJ_G0017975	protein coding gene	Chr11:70520215-70533162 (-)

Human Ortholog

INCA1, inhibitor of CDK, cyclin A1 interacting protein 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

INCA1, inhibitor of CDK, cyclin A1 interacting protein 1
Synonyms

HSD45
Links

HGNC:32224

NCBI Gene ID: 388324

neXtProt AC: NX_Q0VD86

UniProt: Q0VD86
Chr Location

17p13.2; chr17:4988130-4997610 (-) GRCh38

MGI Vertebrate Homology

Inca1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: INCA1
Gene Tree

Inca1

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
1 images
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

2
Targeted

3
Genomic Mutations

2 involving Inca1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit decreased cell proliferation in mouse embryonic fibroblasts and older mice exhibit abnormal spleen architecture, particularly in the white pulp, and extramedullary hematopoiesis.

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All GO Annotations

29
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

724
Tissues

18
cDNA Data

19
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

73
RefSeq

32
UniProt

1
CCDS

CCDS24964.1, CCDS56789.1

Ensembl

ENSMUSG00000057054 (Evidence)
NCBI Gene

103844

			Length	Strain/Species	Flank
genomic	ENSMUSG00000057054	Ensembl Gene Model \| MGI Sequence Detail	11795	C57BL/6J	± kb
transcript	ENSMUST00000108542	Ensembl \| MGI Sequence Detail	1080	Not Applicable
polypeptide	ENSMUSP00000104182	Ensembl \| MGI Sequence Detail	231	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000009028 protein INCA1

(term hierarchy)
InterPro Domains

IPR026238 Protein INCA1
GlyGen

Q6PKN7 1 site, 1 N-linked glycan (1 site)

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All nucleic 19

cDNA 19

Microarray probesets 3

Summaries

All 37

Developmental Gene Expression 1

Gene Ontology 7

Phenotypes 14
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Inca1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr109037	Chr11:70590931-70590996 (-)	17 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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