Tfap2e MGI Mouse Gene Detail - MGI:2679630 - transcription factor AP-2, epsilon

Symbol

Tfap2e
Name

transcription factor AP-2, epsilon
Synonyms

AP-2e, Tcfap2e

Feature Type

protein coding gene
IDs

MGI:2679630
NCBI Gene: 332937
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr4:126609799-126630033 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 60.91 cM
Mapping Data

1 experiment

SNPs within 2kb

749 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2679630	protein coding gene	Chr4:126609796-126630062 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0028786	protein coding gene	Chr4:128424105-128445702 (-)
A/J	MGP_AJ_G0028745	protein coding gene	Chr4:123364663-123384894 (-)
AKR/J	MGP_AKRJ_G0028698	protein coding gene	Chr4:126751743-126771945 (-)
BALB/cJ	MGP_BALBcJ_G0028768	protein coding gene	Chr4:123936820-123957498 (-)
C3H/HeJ	MGP_C3HHeJ_G0028482	protein coding gene	Chr4:126826154-126847177 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0029210	protein coding gene	Chr4:133313866-133335211 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026483	protein coding gene	Chr4:116494683-116515058 (-)
CAST/EiJ	MGP_CASTEiJ_G0027915	protein coding gene	Chr4:124938668-124958876 (-)
CBA/J	MGP_CBAJ_G0028448	protein coding gene	Chr4:136537030-136559619 (-)
DBA/2J	MGP_DBA2J_G0028597	protein coding gene	Chr4:123810476-123830463 (-)
FVB/NJ	MGP_FVBNJ_G0028564	protein coding gene	Chr4:122467601-122487940 (-)
LP/J	MGP_LPJ_G0028698	protein coding gene	Chr4:128705423-128725670 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028590	protein coding gene	Chr4:141552542-141574608 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029248	protein coding gene	Chr4:127112497-127132569 (-)
PWK/PhJ	MGP_PWKPhJ_G0027636	protein coding gene	Chr4:120307895-120328438 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0027462	protein coding gene	Chr4:122945092-122966159 (-)
WSB/EiJ	MGP_WSBEiJ_G0027995	protein coding gene	Chr4:127227545-127248416 (-)

Human Ortholog

TFAP2E, transcription factor AP-2 epsilon

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TFAP2E, transcription factor AP-2 epsilon
Synonyms

AP2E, AP-2epsilon
Links

HGNC:30774

NCBI Gene ID: 339488

neXtProt AC: NX_Q6VUC0

UniProt: Q6VUC0
Chr Location

1p34.3; chr1:35573314-35595591 (+) GRCh38

MGI Vertebrate Homology

Tfap2e stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TFAP2E
Gene Tree

Tfap2e

less

Phenotype Summary

2 phenotypes from 2 alleles in 2 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

2
Radiation induced

1
Targeted

7
Genomic Mutations

4 involving Tfap2e
Find Mice (IMSR)

10 strains or lines available
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a knock-in allele exhibit impaired olfactory bulb neuronal layer development.

less

All GO Annotations

16
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

869
Tissues

75
cDNA Data

21
Literature Summary

22

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA TFAP2E

Xenbase tfap2e

ZFIN tfap2e

less

All Sequences

35
RefSeq

2
UniProt

1
CCDS

CCDS18658.1

Ensembl

ENSMUSG00000042477 (Evidence)
NCBI Gene

332937

			Length	Strain/Species	Flank
genomic	ENSMUSG00000042477	Ensembl Gene Model \| MGI Sequence Detail	20235	C57BL/6J	± kb
transcript	ENSMUST00000048194	Ensembl \| MGI Sequence Detail	2085	Not Applicable
polypeptide	ENSMUSP00000035902	Ensembl \| MGI Sequence Detail	442	Not Applicable

less

UniProt

1 Sequence
Protein Ontology

PR:000031571 transcription factor AP-2-epsilon

(term hierarchy)
InterPro Domains

IPR004979 Transcription factor AP-2

IPR013854 Transcription factor AP-2, C-terminal

less

All nucleic 26

cDNA 21

Primer pair 5

Microarray probesets 2

less

MGI:2140317

Summaries

All 51

Developmental Gene Expression 22

Gene Ontology 4

Phenotypes 14
Earliest

J:84714 Nishijima I, et al., Two new balancer chromosomes on mouse chromosome 4 to facilitate functional annotation of human chromosome 1p. Genesis. 2003 Jul;36(3):142-8
Latest

J:348733 Staebler S, et al., Transcription factor activating enhancer-binding protein 2epsilon (AP2epsilon) modulates phenotypic plasticity and progression of malignant melanoma. Cell Death Dis. 2024 May 21;15(5):351

TSS for Tfap2e:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr43389	Chr4:126630029-126630038 (-)	-1 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24