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P4ha3 Gene Detail
Summary
  • Symbol
    P4ha3
  • Name
    procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide III
  • Synonyms
    D930031A02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444049
    NCBI Gene: 320452
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:99934727-99968906 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 7, 54.34 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1087 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444049
protein coding gene Chr7:99934637-99968908 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032566
protein coding gene Chr7:103159366-103194324 (+)
A/J MGP_AJ_G0032540
protein coding gene Chr7:100566621-100601791 (+)
AKR/J MGP_AKRJ_G0032476
protein coding gene Chr7:102956368-102992402 (+)
BALB/cJ MGP_BALBcJ_G0032551
protein coding gene Chr7:100241364-100276204 (+)
C3H/HeJ MGP_C3HHeJ_G0032266
protein coding gene Chr7:103326465-103361545 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033049
protein coding gene Chr7:107076208-107117671 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030043
protein coding gene Chr7:102969627-103003917 (+)
CAST/EiJ MGP_CASTEiJ_G0031593
protein coding gene Chr7:94874408-94911559 (+)
CBA/J MGP_CBAJ_G0032233
protein coding gene Chr7:110761567-110795117 (+)
DBA/2J MGP_DBA2J_G0032384
protein coding gene Chr7:98898755-98932694 (+)
FVB/NJ MGP_FVBNJ_G0032341
protein coding gene Chr7:98686346-98720359 (+)
LP/J MGP_LPJ_G0032474
protein coding gene Chr7:104515571-104551528 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032374
protein coding gene Chr7:112177845-112224405 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033071
protein coding gene Chr7:102227030-102260950 (+)
PWK/PhJ MGP_PWKPhJ_G0031311
protein coding gene Chr7:92002117-92036823 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031154
protein coding gene Chr7:89537241-89573740 (+)
WSB/EiJ MGP_WSBEiJ_G0031710
protein coding gene Chr7:102928343-102962142 (+)



Homology
more
  • Human Ortholog
    P4HA3, prolyl 4-hydroxylase subunit alpha 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    P4HA3, prolyl 4-hydroxylase subunit alpha 3
  • Links
    NCBI Gene ID: 283208
    neXtProt AC: NX_Q7Z4N8
    UniProt: Q7Z4N8

  • Chr Location
    11q13.4; chr11:74235801-74311640 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000051048 Ensembl Gene Model | MGI Sequence Detail 34180 C57BL/6J ±  kb
    transcript ENSMUST00000057023 Ensembl | MGI Sequence Detail 2361 Not Applicable  
    polypeptide ENSMUSP00000055297 Ensembl | MGI Sequence Detail 542 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 6
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 4
      Gene Ontology 7
      Phenotypes 15
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    10/22/2024
    MGI 6.24
    The Jackson Laboratory