P4ha3 MGI Mouse Gene Detail - MGI:2444049 - procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide III

Symbol

P4ha3
Name

procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide III
Synonyms

D930031A02Rik

Feature Type

protein coding gene
IDs

MGI:2444049
NCBI Gene: 320452
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr7:99934727-99968906 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 54.34 cM
Mapping Data

1 experiment

SNPs within 2kb

1087 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2444049	protein coding gene	Chr7:99934637-99968908 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032566	protein coding gene	Chr7:103159366-103194324 (+)
A/J	MGP_AJ_G0032540	protein coding gene	Chr7:100566621-100601791 (+)
AKR/J	MGP_AKRJ_G0032476	protein coding gene	Chr7:102956368-102992402 (+)
BALB/cJ	MGP_BALBcJ_G0032551	protein coding gene	Chr7:100241364-100276204 (+)
C3H/HeJ	MGP_C3HHeJ_G0032266	protein coding gene	Chr7:103326465-103361545 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033049	protein coding gene	Chr7:107076208-107117671 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030043	protein coding gene	Chr7:102969627-103003917 (+)
CAST/EiJ	MGP_CASTEiJ_G0031593	protein coding gene	Chr7:94874408-94911559 (+)
CBA/J	MGP_CBAJ_G0032233	protein coding gene	Chr7:110761567-110795117 (+)
DBA/2J	MGP_DBA2J_G0032384	protein coding gene	Chr7:98898755-98932694 (+)
FVB/NJ	MGP_FVBNJ_G0032341	protein coding gene	Chr7:98686346-98720359 (+)
LP/J	MGP_LPJ_G0032474	protein coding gene	Chr7:104515571-104551528 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032374	protein coding gene	Chr7:112177845-112224405 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033071	protein coding gene	Chr7:102227030-102260950 (+)
PWK/PhJ	MGP_PWKPhJ_G0031311	protein coding gene	Chr7:92002117-92036823 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031154	protein coding gene	Chr7:89537241-89573740 (+)
WSB/EiJ	MGP_WSBEiJ_G0031710	protein coding gene	Chr7:102928343-102962142 (+)

Human Ortholog

P4HA3, prolyl 4-hydroxylase subunit alpha 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

P4HA3, prolyl 4-hydroxylase subunit alpha 3
Links

HGNC:30135

NCBI Gene ID: 283208

neXtProt AC: NX_Q7Z4N8

UniProt: Q7Z4N8
Chr Location

11q13.4; chr11:74235801-74311640 (-) GRCh38

MGI Vertebrate Homology

P4ha3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: P4HA3
Gene Tree

P4ha3

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

2
Radiation induced

1
Genomic Mutations

2 involving P4ha3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

29 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

9
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1087
Tissues

135
cDNA Data

6
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

45
RefSeq

7
UniProt

4
CCDS

CCDS21496.1

Ensembl

ENSMUSG00000051048 (Evidence)
NCBI Gene

320452

			Length	Strain/Species	Flank
genomic	ENSMUSG00000051048	Ensembl Gene Model \| MGI Sequence Detail	34180	C57BL/6J	± kb
transcript	ENSMUST00000057023	Ensembl \| MGI Sequence Detail	2361	Not Applicable
polypeptide	ENSMUSP00000055297	Ensembl \| MGI Sequence Detail	542	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000012198 prolyl 4-hydroxylase subunit alpha-3

(term hierarchy)
EC

1.14.11.2
InterPro Domains

IPR005123 Oxoglutarate/iron-dependent dioxygenase

IPR045054 Prolyl 4-hydroxylase

IPR006620 Prolyl 4-hydroxylase, alpha subunit

IPR044862 Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain

IPR013547 Prolyl 4-hydroxylase alpha-subunit, N-terminal

IPR011990 Tetratricopeptide-like helical domain superfamily
GlyGen

Q6W3F0 2 sites

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All nucleic 7

cDNA 6

Primer pair 1

Microarray probesets 2

Summaries

All 40

Developmental Gene Expression 4

Gene Ontology 7

Phenotypes 15
Earliest

J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for P4ha3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr68110	Chr7:99934685-99934771 (+)	1 bp
Tssr68111	Chr7:99968237-99968255 (+)	33,519 bp
Tssr68112	Chr7:99968301-99968312 (+)	33,580 bp
Tssr68113	Chr7:99968456-99968479 (+)	33,741 bp
Tssr68114	Chr7:99968611-99968640 (+)	33,899 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/22/2024 MGI 6.24