Larp1 MGI Mouse Gene Detail - MGI:1890165 - La ribonucleoprotein 1, translational regulator

Symbol

Larp1
Name

La ribonucleoprotein 1, translational regulator
Synonyms

1810024J12Rik, 3110040D16Rik, Larp, mKIAA0731

Feature Type

protein coding gene
IDs

MGI:1890165
NCBI Gene: 73158
Alliance

gene page
Transcription Start Sites

17 TSS

Sequence Map

Chr11:57899890-57952860 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 35.55 cM, cytoband B2
Mapping Data

2 experiments

SNPs within 2kb

978 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1890165	protein coding gene	Chr11:57899711-57952860 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018341	protein coding gene	Chr11:57675434-57730846 (+)
A/J	MGP_AJ_G0018311	protein coding gene	Chr11:55490548-55543304 (+)
AKR/J	MGP_AKRJ_G0018280	protein coding gene	Chr11:57318103-57376604 (+)
BALB/cJ	MGP_BALBcJ_G0018282	protein coding gene	Chr11:55835264-55887831 (+)
C3H/HeJ	MGP_C3HHeJ_G0018093	protein coding gene	Chr11:57241264-57297177 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018733	protein coding gene	Chr11:59436141-59494880 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016383	protein coding gene	Chr11:52846088-52899208 (+)
CAST/EiJ	MGP_CASTEiJ_G0017658	protein coding gene	Chr11:57326219-57385021 (+)
CBA/J	MGP_CBAJ_G0018068	protein coding gene	Chr11:62193364-62249003 (+)
DBA/2J	MGP_DBA2J_G0018177	protein coding gene	Chr11:55142194-55195148 (+)
FVB/NJ	MGP_FVBNJ_G0018168	protein coding gene	Chr11:54839653-54893673 (+)
LP/J	MGP_LPJ_G0018252	protein coding gene	Chr11:58209022-58265397 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018194	protein coding gene	Chr11:63317578-63374410 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018776	protein coding gene	Chr11:57338470-57393620 (+)
PWK/PhJ	MGP_PWKPhJ_G0017430	protein coding gene	Chr11:55739781-55794498 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017225	protein coding gene	Chr11:57231613-57291982 (+)
WSB/EiJ	MGP_WSBEiJ_G0017705	protein coding gene	Chr11:56989301-57046409 (+)

Human Ortholog

LARP1, La ribonucleoprotein 1, translational regulator

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LARP1, La ribonucleoprotein 1, translational regulator
Synonyms

Lar1, LARP, Lhp1
Links

HGNC:29531

NCBI Gene ID: 23367

neXtProt AC: NX_Q6PKG0

UniProt: Q6PKG0
Chr Location

5q33.2; chr5:154682979-154817605 (+) GRCh38

MGI Vertebrate Homology

Larp1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LARP1
Gene Tree

Larp1

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Phenotype Summary

19 phenotypes from 2 alleles in 3 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

27
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

21
Targeted

3
Genomic Mutations

1 involving Larp1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

56 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

52
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

747
Tissues

39
cDNA Data

10
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase larp1

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All Sequences

46
RefSeq

6
UniProt

4
CCDS

CCDS56771.1

Ensembl

ENSMUSG00000037331 (Evidence)
NCBI Gene

73158

			Length	Strain/Species	Flank
genomic	ENSMUSG00000037331	Ensembl Gene Model \| MGI Sequence Detail	52971	C57BL/6J	± kb
transcript	ENSMUST00000071487	Ensembl \| MGI Sequence Detail	6614	Not Applicable
polypeptide	ENSMUSP00000071421	Ensembl \| MGI Sequence Detail	1072	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000009668 La-related protein 1

(term hierarchy)
InterPro Domains

IPR045180 La domain containing protein

IPR006607 LARP1-like, DM15 repeat

IPR006630 La-type HTH domain

IPR036390 Winged helix DNA-binding domain superfamily

IPR036388 Winged helix-like DNA-binding domain superfamily
GlyGen

Q6ZQ58 2 sites, 1 O-linked glycan (2 sites)

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All nucleic 11

cDNA 10

Primer pair 1

Microarray probesets 5

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MGI:1916410, MGI:1920408

Summaries

All 42

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 16
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Larp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr101652	Chr11:57899687-57899761 (+)	-166 bp
Tssr101653	Chr11:57899763-57899785 (+)	-116 bp
Tssr101654	Chr11:57899792-57899813 (+)	-87 bp
Tssr101655	Chr11:57899905-57899916 (+)	21 bp
Tssr101656	Chr11:57899957-57899970 (+)	74 bp
Tssr101657	Chr11:57899987-57900032 (+)	120 bp
Tssr101661	Chr11:57903357-57903361 (+)	3,469 bp
Tssr101662	Chr11:57931239-57931248 (+)	31,354 bp
Tssr101663	Chr11:57933930-57933935 (+)	34,043 bp
Tssr101664	Chr11:57940421-57940469 (+)	40,555 bp
Tssr101665	Chr11:57940473-57940485 (+)	40,589 bp
Tssr101666	Chr11:57942132-57942152 (+)	42,252 bp
Tssr101667	Chr11:57942161-57942171 (+)	42,276 bp
Tssr101668	Chr11:57950052-57950074 (+)	50,173 bp
Tssr101669	Chr11:57950147-57950163 (+)	50,265 bp
Tssr101670	Chr11:57950208-57950253 (+)	50,341 bp
Tssr101671	Chr11:57951825-57951837 (+)	51,941 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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