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Ncapd3 Gene Detail
Summary
  • Symbol
    Ncapd3
  • Name
    non-SMC condensin II complex, subunit D3
  • Synonyms
    2810487N22Rik, 4632407J06Rik, B130055D15Rik, mKIAA0056
  • Feature Type
    protein coding gene
  • IDs
    MGI:2142989
    NCBI Gene: 78658
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:26941471-27006611 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 12.12 cM, cytoband A4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1477 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2142989
 protein coding gene Chr9:26941455-27008667 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034506
 protein coding gene Chr9:24492058-24558463 (+)
A/J MGP_AJ_G0034484
 protein coding gene Chr9:23949494-24016166 (+)
AKR/J MGP_AKRJ_G0034410
 protein coding gene Chr9:24428300-24492973 (+)
BALB/cJ MGP_BALBcJ_G0034475
 protein coding gene Chr9:23833646-23897844 (+)
C3H/HeJ MGP_C3HHeJ_G0034187
 protein coding gene Chr9:24800507-24868876 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034996
 protein coding gene Chr9:25398391-25477403 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031926
 protein coding gene Chr9:22866576-22929079 (+)
CAST/EiJ MGP_CASTEiJ_G0033510
 protein coding gene Chr9:24598152-24665813 (+)
CBA/J MGP_CBAJ_G0034160
 protein coding gene Chr9:26305766-26377591 (+)
DBA/2J MGP_DBA2J_G0034318
 protein coding gene Chr9:23980319-24046584 (+)
FVB/NJ MGP_FVBNJ_G0034261
 protein coding gene Chr9:23407973-23473271 (+)
LP/J MGP_LPJ_G0034404
 protein coding gene Chr9:24690938-24756087 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034305
 protein coding gene Chr9:28001567-28069038 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035016
 protein coding gene Chr9:24417902-24485555 (+)
PWK/PhJ MGP_PWKPhJ_G0033215
 protein coding gene Chr9:23883344-23945285 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033049
 protein coding gene Chr9:24472269-24547621 (+)
WSB/EiJ MGP_WSBEiJ_G0033625
 protein coding gene Chr9:24139253-24205005 (+)



Homology
more
  • Human Ortholog
    NCAPD3, non-SMC condensin II complex subunit D3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NCAPD3, non-SMC condensin II complex subunit D3
  • Synonyms
    CAP-D3, CAPD3, hCAP-D3, hcp-6, hHCP-6, MCPH22
  • Links
    NCBI Gene ID: 23310
    neXtProt AC: NX_P42695
    UniProt: P42695

  • Chr Location
    11q25; chr11:134150113-134225504 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human NCAPD3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    1 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit complete embryonic lethality between implantation and somite formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    707
  • Tissues
    1
  • cDNA Data
    117
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035024 Ensembl Gene Model | MGI Sequence Detail 65141 C57BL/6J ±  kb
    transcript ENSMUST00000216677 Ensembl | MGI Sequence Detail 5149 Not Applicable  
    polypeptide ENSMUSP00000150938 Ensembl | MGI Sequence Detail 1506 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000011021 condensin-2 complex subunit D3
      (term hierarchy)
    • InterPro Domains
      IPR011989 Armadillo-like helical
      IPR016024 Armadillo-type fold
      IPR012371 Condensin-2 complex subunit D3
      IPR032682 Condensin complex subunit 1, C-terminal
      IPR026971 Condensin subunit 1/Condensin-2 complex subunit D3
    • GlyGen
      Q6ZQK0 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 118
      cDNA 117
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1922964, MGI:1925908, MGI:2143198
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 1
      Gene Ontology 8
      Phenotypes 10
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory