Gimap8 MGI Mouse Gene Detail - MGI:2685303 - GTPase, IMAP family member 8

Symbol

Gimap8
Name

GTPase, IMAP family member 8
Synonyms

IAN9, LOC243374

Feature Type

protein coding gene
IDs

MGI:2685303
NCBI Gene: 243374
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr6:48624168-48637809 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 23.62 cM
Mapping Data

1 experiment

SNPs within 2kb

394 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2685303	protein coding gene	Chr6:48624120-48637809 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030704	protein coding gene	Chr6:47599669-47611777 (+)
A/J	MGP_AJ_G0030675	protein coding gene	Chr6:45438352-45451911 (+)
AKR/J	MGP_AKRJ_G0030600	protein coding gene	Chr6:47031760-47045274 (+)
BALB/cJ	MGP_BALBcJ_G0030685	protein coding gene	Chr6:45768705-45781899 (+)
C3H/HeJ	MGP_C3HHeJ_G0030398	protein coding gene	Chr6:47037809-47052345 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031140	protein coding gene	Chr6:48715688-48727621 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028347	protein coding gene	Chr6:43066485-43078478 (+)
CAST/EiJ	MGP_CASTEiJ_G0029802	protein coding gene	Chr6:46764517-46776499 (+)
CBA/J	MGP_CBAJ_G0030373	protein coding gene	Chr6:50741528-50755009 (+)
DBA/2J	MGP_DBA2J_G0030522	protein coding gene	Chr6:45354899-45368541 (+)
FVB/NJ	MGP_FVBNJ_G0030474	protein coding gene	Chr6:44985797-44999065 (+)
LP/J	MGP_LPJ_G0030607	protein coding gene	Chr6:47579883-47591816 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030508	protein coding gene	Chr6:53547330-53560044 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031169	protein coding gene	Chr6:46901363-46913485 (+)
PWK/PhJ	MGP_PWKPhJ_G0029514	protein coding gene	Chr6:44887379-44899749 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029350	protein coding gene	Chr6:46250474-46263544 (+)
WSB/EiJ	MGP_WSBEiJ_G0029879	protein coding gene	Chr6:46900457-46912532 (+)

Human Ortholog

GIMAP8, GTPase, IMAP family member 8

Vertebrate Orthologs

6

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GIMAP8, GTPase, IMAP family member 8
Synonyms

IAN6, IAN-9, IAN9, IANT
Links

HGNC:21792

NCBI Gene ID: 155038

neXtProt AC: NX_Q8ND71

UniProt: Q8ND71
Chr Location

7q36.1; chr7:150450630-150479393 (+) GRCh38

MGI Vertebrate Homology

Gimap8 stringent orthology
1 human;1 mouse;1 rat;4 zebrafish
HCOP

vertebrate homology predictions: GIMAP8
Gene Tree

Gimap8

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Targeted

3
Incidental Mutations

APF
Find Mice (IMSR)

34 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

7
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

745
Tissues

32
cDNA Data

32
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

47
RefSeq

8
UniProt

2
CCDS

CCDS20108.1, CCDS85043.1

Ensembl

ENSMUSG00000064262 (Evidence)
NCBI Gene

243374

			Length	Strain/Species	Flank
genomic	ENSMUSG00000064262	Ensembl Gene Model \| MGI Sequence Detail	13642	C57BL/6J	± kb
transcript	ENSMUST00000203083	Ensembl \| MGI Sequence Detail	2579	Not Applicable
polypeptide	ENSMUSP00000145286	Ensembl \| MGI Sequence Detail	688	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000007980 GTPase IMAP family member 8

(term hierarchy)
InterPro Domains

IPR006703 AIG1-type guanine nucleotide-binding (G) domain

IPR045058 GTPase GIMA/IAN/Toc

IPR027417 P-loop containing nucleoside triphosphate hydrolase
GlyGen

Q75N62 1 site, 1 O-linked glycan (1 site)

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All nucleic 32

cDNA 32

Microarray probesets 2

Summaries

All 26

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 5
Earliest

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Gimap8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr56151	Chr6:48624142-48624153 (+)	-20 bp
Tssr56152	Chr6:48624158-48624232 (+)	27 bp
Tssr56153	Chr6:48624243-48624252 (+)	80 bp
Tssr56154	Chr6:48624256-48624261 (+)	91 bp
Tssr56155	Chr6:48624322-48624338 (+)	162 bp
Tssr56156	Chr6:48624346-48624357 (+)	184 bp
Tssr56157	Chr6:48624358-48624371 (+)	197 bp
Tssr56158	Chr6:48628706-48628709 (+)	4,540 bp
Tssr56159	Chr6:48636390-48636400 (+)	12,227 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24