Spag5 MGI Mouse Gene Detail - MGI:1927470 - sperm associated antigen 5

Symbol

Spag5
Name

sperm associated antigen 5
Synonyms

Astrin, D11Bhm180e, Deepest, MAP126, Mastrin, s17, S17

Feature Type

protein coding gene
IDs

MGI:1927470
NCBI Gene: 54141
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr11:78192412-78213283 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 46.74 cM, cytoband B5
Mapping Data

5 experiments

SNPs within 2kb

498 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1927470	protein coding gene	Chr11:78192355-78213283 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018774	protein coding gene	Chr11:79294522-79317744 (+)
A/J	MGP_AJ_G0018740	protein coding gene	Chr11:76264368-76285718 (+)
AKR/J	MGP_AKRJ_G0018710	protein coding gene	Chr11:78569163-78591160 (+)
BALB/cJ	MGP_BALBcJ_G0018714	protein coding gene	Chr11:76672365-76694406 (+)
C3H/HeJ	MGP_C3HHeJ_G0018527	protein coding gene	Chr11:78609970-78631062 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019165	protein coding gene	Chr11:81767681-81791286 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016800	protein coding gene	Chr11:73240829-73261622 (+)
CAST/EiJ	MGP_CASTEiJ_G0018081	protein coding gene	Chr11:79058469-79080538 (+)
CBA/J	MGP_CBAJ_G0018497	protein coding gene	Chr11:85345890-85371407 (+)
DBA/2J	MGP_DBA2J_G0018606	protein coding gene	Chr11:75843229-75863881 (+)
FVB/NJ	MGP_FVBNJ_G0018596	protein coding gene	Chr11:75432305-75452648 (+)
LP/J	MGP_LPJ_G0018677	protein coding gene	Chr11:79830873-79852847 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018622	protein coding gene	Chr11:85750221-85776384 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019205	protein coding gene	Chr11:78813414-78838845 (+)
PWK/PhJ	MGP_PWKPhJ_G0017852	protein coding gene	Chr11:76630693-76652291 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017643	protein coding gene	Chr11:78427157-78449974 (+)
WSB/EiJ	MGP_WSBEiJ_G0018134	protein coding gene	Chr11:78633686-78659390 (+)

Human Ortholog

SPAG5, sperm associated antigen 5

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SPAG5, sperm associated antigen 5
Synonyms

DEEPEST, hMAP126, MAP126
Links

HGNC:13452

NCBI Gene ID: 10615

neXtProt AC: NX_Q96R06

UniProt: Q96R06
Chr Location

17q11.2; chr17:28577565-28599025 (-) GRCh38

MGI Vertebrate Homology

Spag5 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SPAG5
Gene Tree

Spag5

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
17 phenotype references

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

3
Targeted

4
Genomic Mutations

2 involving Spag5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

40 strains or lines available

Mice homozygous for a targeted mutation are viable and fertile with normal breeding and mating behavio; no abnormalities in male reproductive system anatomy or histology or in spermatogenesis were detectable.

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All GO Annotations

44
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

862
Tissues

140
cDNA Data

9
Literature Summary

11

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase spag5

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All Sequences

52
RefSeq

10
UniProt

2
CCDS

CCDS25098.1

Ensembl

ENSMUSG00000002055 (Evidence)
NCBI Gene

54141

			Length	Strain/Species	Flank
genomic	54141	NCBI Gene Model \| MGI Sequence Detail	20872	C57BL/6J	± kb
transcript	NR_156178	RefSeq \| MGI Sequence Detail	3852	ZRU/MplStud
polypeptide	Q7TME2	UniProt \| EBI \| MGI Sequence Detail	1165	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000015459 sperm-associated antigen 5

(term hierarchy)
InterPro Domains

IPR028728 Sperm-associated antigen 5
GlyGen

Q7TME2 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)

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All nucleic 19

Genomic 5

cDNA 10

Primer pair 3

Other 1

Microarray probesets 7

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MGD-MRK-35274, MGI:106814, MGI:2144324

Summaries

All 55

Developmental Gene Expression 11

Gene Ontology 10

Phenotypes 17
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:327275 Mora-Bermudez F, et al., Longer metaphase and fewer chromosome segregation errors in modern human than Neanderthal brain development. Sci Adv. 2022 Jul 29;8(30):eabn7702

TSS for Spag5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr103264	Chr11:78192405-78192432 (+)	7 bp
Tssr103265	Chr11:78192436-78192460 (+)	36 bp
Tssr103266	Chr11:78205886-78205902 (+)	13,482 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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