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Huwe1 Gene Detail
Summary
  • Symbol
    Huwe1
  • Name
    HECT, UBA and WWE domain containing 1
  • Synonyms
    5430439H10Rik, Arf-bp1, C430014N20Rik, Ib772, LOC382250, mKIAA0312, Mule, Ureb1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926884
    NCBI Gene: 59026
  • Alliance
  • Transcription Start Sites
    23 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:150583803-150718413 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome X, 68.46 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1784 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926884
protein coding gene ChrX:150583779-150718413 (+)
129S1/SvImJ MGP_129S1SvImJ_G0036179
protein coding gene ChrX:149553263-149688073 (+)
A/J MGP_AJ_G0036155
protein coding gene ChrX:148744014-148880853 (+)
AKR/J MGP_AKRJ_G0036081
protein coding gene ChrX:153552852-153692407 (+)
BALB/cJ MGP_BALBcJ_G0036146
protein coding gene ChrX:146931107-147072970 (+)
C3H/HeJ MGP_C3HHeJ_G0035854
protein coding gene ChrX:149764355-149900020 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036671
protein coding gene ChrX:153793944-153931339 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033495
protein coding gene ChrX:140439842-140577828 (+)
CAST/EiJ MGP_CASTEiJ_G0035145
protein coding gene ChrX:129167633-129309811 (+)
CBA/J MGP_CBAJ_G0035831
protein coding gene ChrX:158342649-158479585 (+)
DBA/2J MGP_DBA2J_G0035989
protein coding gene ChrX:147822066-147957567 (+)
FVB/NJ MGP_FVBNJ_G0035923
protein coding gene ChrX:146942843-147078814 (+)
LP/J MGP_LPJ_G0036080
protein coding gene ChrX:150637075-150774433 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035959
protein coding gene ChrX:166483459-166641896 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036706
protein coding gene ChrX:149065668-149204731 (+)
PWK/PhJ MGP_PWKPhJ_G0034839
protein coding gene ChrX:126129558-126268770 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034665
protein coding gene ChrX:129640768-129782009 (+)
WSB/EiJ MGP_WSBEiJ_G0035280
protein coding gene ChrX:147127777-147267007 (+)



Homology
more
  • Human Ortholog
    HUWE1, HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HUWE1, HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  • Synonyms
    ARF-BP1, HECTH9, HSPC272, Ib772, LASU1, MRXST, MULE, URE-B1, UREB1
  • Links
    NCBI Gene ID: 10075
    neXtProt AC: NX_Q7Z6Z7
    UniProt: Q7Z6Z7

  • Chr Location
    Xp11.22; chrX:53532096-53686752 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with human HUWE1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    64 phenotypes from 7 alleles in 10 genetic backgrounds
    9 phenotypes from multigenic genotypes
    39 images
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in neurons results in neonatal lethality, poorly developed dentate gyrus, small cerebellum, increased cortex density, and increased neuronal precursor cell proliferation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025261 Ensembl Gene Model | MGI Sequence Detail 134611 C57BL/6J ±  kb
    transcript ENSMUST00000026292 Ensembl | MGI Sequence Detail 14579 Not Applicable  
    polypeptide ENSMUSP00000026292 Ensembl | MGI Sequence Detail 4378 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      Genomic 1
      cDNA 26

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:1918622, MGI:2147973, MGI:2148063, MGI:2443454, MGI:2686564
    References
    more
    • Summaries
      All 80
      Developmental Gene Expression 6
      Gene Ontology 9
      Phenotypes 36
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:348964 Amici DR, et al., Tight regulation of a nuclear HAPSTR1-HUWE1 pathway essential for mammalian life. Life Sci Alliance. 2024 May;7(5)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    11/19/2024
    MGI 6.24
    The Jackson Laboratory