Dcstamp MGI Mouse Gene Detail - MGI:1923016 - dendrocyte expressed seven transmembrane protein

Symbol

Dcstamp
Name

dendrocyte expressed seven transmembrane protein
Synonyms

4833414I07Rik, DC-STAMP, Tm7sf4

Feature Type

protein coding gene
IDs

MGI:1923016
NCBI Gene: 75766
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr15:39609326-39624334 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 15.51 cM, cytoband C
Mapping Data

2 experiments

SNPs within 2kb

620 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1923016	protein coding gene	Chr15:39609326-39624334 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021816	protein coding gene	Chr15:38196968-38211716 (+)
A/J	MGP_AJ_G0021776	protein coding gene	Chr15:36703081-36717779 (+)
AKR/J	MGP_AKRJ_G0021757	protein coding gene	Chr15:37798225-37814148 (+)
BALB/cJ	MGP_BALBcJ_G0021783	protein coding gene	Chr15:36757778-36773215 (+)
C3H/HeJ	MGP_C3HHeJ_G0021557	protein coding gene	Chr15:37717593-37736526 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022222	protein coding gene	Chr15:39648304-39664430 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019759	protein coding gene	Chr15:34463400-34478641 (+)
CAST/EiJ	MGP_CASTEiJ_G0021074	protein coding gene	Chr15:38179364-38197236 (+)
CBA/J	MGP_CBAJ_G0021526	protein coding gene	Chr15:41062125-41086547 (+)
DBA/2J	MGP_DBA2J_G0021650	protein coding gene	Chr15:36547471-36567384 (+)
FVB/NJ	MGP_FVBNJ_G0021628	protein coding gene	Chr15:35929521-35945174 (+)
LP/J	MGP_LPJ_G0021720	protein coding gene	Chr15:38008007-38026451 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021652	protein coding gene	Chr15:44069879-44084498 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022245	protein coding gene	Chr15:37954170-37974138 (+)
PWK/PhJ	MGP_PWKPhJ_G0020819	protein coding gene	Chr15:36601384-36618965 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020656	protein coding gene	Chr15:37634265-37650818 (+)
WSB/EiJ	MGP_WSBEiJ_G0021129	protein coding gene	Chr15:37870062-37884878 (+)

Human Ortholog

DCSTAMP, dendrocyte expressed seven transmembrane protein

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DCSTAMP, dendrocyte expressed seven transmembrane protein
Synonyms

FIND, hDC-STAMP, TM7SF4
Links

HGNC:18549

NCBI Gene ID: 81501

neXtProt AC: NX_Q9H295

UniProt: Q9H295
Chr Location

8q22.3; chr8:104339087-104356689 (+) GRCh38

MGI Vertebrate Homology

Dcstamp stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: DCSTAMP
Gene Tree

Dcstamp

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

2
Endonuclease-mediated

5
Gene trapped

1
Targeted

1
Genomic Mutations

2 involving Dcstamp
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

29 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Targeted disruption of this gene causes complete loss of osteoclast and macrophage cell fusion and leads to reduced bone-resorbing activity and mild osteopetrosis.

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All GO Annotations

28
GO References

14

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

4

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

58
RefSeq

12
UniProt

5
CCDS

CCDS27444.1, CCDS88757.1, CCDS88758.1, CCDS88759.1

Ensembl

ENSMUSG00000022303 (Evidence)
NCBI Gene

75766

			Length	Strain/Species	Flank
genomic	75766	NCBI Gene Model \| MGI Sequence Detail	15009	C57BL/6J	± kb
transcript	NM_029422	RefSeq \| MGI Sequence Detail	1999	C57BL/6
polypeptide	Q7TNJ0	UniProt \| EBI \| MGI Sequence Detail	470	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000016389 dendritic cell-specific transmembrane protein

(term hierarchy)
InterPro Domains

IPR051856 Cell Surface Receptor and E3 Ligase Protein

IPR012858 Dendritic cell-specific transmembrane protein-like

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All nucleic 4

cDNA 4

Microarray probesets 2

Summaries

All 51

Gene Ontology 14

Phenotypes 18
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:347442 Garcia-Hernandez ML, et al., Dendritic cell-specific transmembrane protein is required for synovitis and bone resorption in inflammatory arthritis. Front Immunol. 2022;13:1026574

TSS for Dcstamp:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr131164	Chr15:39609322-39609333 (+)	2 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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