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Tlcd3b Gene Detail
Summary
  • Symbol
    Tlcd3b
  • Name
    TLC domain containing 3B
  • Synonyms
    1500016O10Rik, A330104J06Rik, Fam57b
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916202
    NCBI Gene: 68952
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:126413213-126429391 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 69.25 cM, cytoband F4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    391 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916202
 protein coding gene Chr7:126396840-126429391 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033001
 protein coding gene Chr7:131096015-131132239 (+)
A/J MGP_AJ_G0032984
 protein coding gene Chr7:127623643-127656200 (+)
AKR/J MGP_AKRJ_G0032916
 protein coding gene Chr7:130857199-130891414 (+)
BALB/cJ MGP_BALBcJ_G0032989
 protein coding gene Chr7:127285347-127319069 (+)
C3H/HeJ MGP_C3HHeJ_G0032699
 protein coding gene Chr7:130794861-130829059 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033495
 protein coding gene Chr7:136190425-136228313 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030467
 protein coding gene Chr7:128816125-128849906 (+)
CAST/EiJ MGP_CASTEiJ_G0032028
 protein coding gene Chr7:122581787-122615106 (+)
CBA/J MGP_CBAJ_G0032672
 protein coding gene Chr7:140773852-140814802 (+)
DBA/2J MGP_DBA2J_G0032824
 protein coding gene Chr7:125597201-125630779 (+)
FVB/NJ MGP_FVBNJ_G0032777
 protein coding gene Chr7:125445899-125481962 (+)
LP/J MGP_LPJ_G0032918
 protein coding gene Chr7:132566394-132601203 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032809
 protein coding gene Chr7:141958265-141992504 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033514
 protein coding gene Chr7:129864398-129900747 (+)
PWK/PhJ MGP_PWKPhJ_G0031735
 protein coding gene Chr7:118592299-118625559 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031581
 protein coding gene Chr7:116714057-116746439 (+)
WSB/EiJ MGP_WSBEiJ_G0032140
 protein coding gene Chr7:130843922-130880578 (+)



Homology
more
  • Human Ortholog
    TLCD3B, TLC domain containing 3B
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TLCD3B, TLC domain containing 3B
  • Synonyms
    CORD22, FAM57B, FP1188
  • Links
    NCBI Gene ID: 83723
    neXtProt AC: NX_Q71RH2
    UniProt: Q71RH2

  • Chr Location
    16p11.2; chr16:30024427-30053040 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Tlcd3b mouse models; 1 with human TLCD3B associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 2 genetic backgrounds
    46 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    878
  • Tissues
    31
  • cDNA Data
    57
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 68952 NCBI Gene Model | MGI Sequence Detail 16179 C57BL/6J ±  kb
    transcript NM_029978 RefSeq | MGI Sequence Detail 2348 C57BL/6  
    polypeptide Q7TNV1 UniProt | EBI | MGI Sequence Detail 275 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 58
      cDNA 58

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1925035, MGI:2141927, MGI:2142201, MGI:6390573
    References
    more
    • Summaries
      All 78
      Developmental Gene Expression 4
      Diseases 4
      Gene Ontology 5
      Phenotypes 46
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:349484 Henis M, et al., The autism susceptibility kinase, TAOK2, phosphorylates eEF2 and modulates translation. Sci Adv. 2024 Apr 12;10(15):eadf7001
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory