Defb34 MGI Mouse Gene Detail - MGI:2672979

Symbol

Defb34
Name

defensin beta 34

Feature Type

protein coding gene
IDs

MGI:2672979
NCBI Gene: 360211
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr8:19173768-19176556 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 10.35 cM
Mapping Data

1 experiment

SNPs within 2kb

244 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2672979	protein coding gene	Chr8:19173744-19176556 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033412	protein coding gene	Chr8:16609813-16612602 (+)
A/J	MGP_AJ_G0033393	protein coding gene	Chr8:16036096-16038885 (+)
AKR/J	MGP_AKRJ_G0033323	protein coding gene	Chr8:16521197-16523985 (+)
BALB/cJ	MGP_BALBcJ_G0033393	protein coding gene	Chr8:16155505-16158294 (+)
C3H/HeJ	MGP_C3HHeJ_G0033105	protein coding gene	Chr8:16719412-16722201 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033906	protein coding gene	Chr8:17150981-17153769 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030873	protein coding gene	Chr8:15319429-15322206 (+)
CAST/EiJ	MGP_CASTEiJ_G0032428	protein coding gene	Chr8:16552273-16555051 (+)
CBA/J	MGP_CBAJ_G0033079	protein coding gene	Chr8:17910870-17913659 (+)
DBA/2J	MGP_DBA2J_G0033233	protein coding gene	Chr8:15989486-15992275 (+)
FVB/NJ	MGP_FVBNJ_G0033181	protein coding gene	Chr8:15997324-16000113 (+)
LP/J	MGP_LPJ_G0033326	protein coding gene	Chr8:16666805-16669589 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033218	protein coding gene	Chr8:18038091-18040880 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033923	protein coding gene	Chr8:16526299-16529087 (+)
PWK/PhJ	MGP_PWKPhJ_G0032141	protein coding gene	Chr8:16009411-16012536 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031982	protein coding gene	Chr8:16446266-16451954 (+)
WSB/EiJ	MGP_WSBEiJ_G0032545	protein coding gene	Chr8:16623830-16626619 (+)

Human Ortholog

DEFB106A, defensin beta 106A

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DEFB106A, defensin beta 106A
Synonyms

BD-6, DEFB106, DEFB-6
Links

HGNC:18088

NCBI Gene ID: 245909

neXtProt AC: NX_Q8N104

UniProt: Q8N104
Chr Location

8p23.1

Human Ortholog

DEFB106B, defensin beta 106B
Synonyms

BD-6, DEFB-6
Links

HGNC:28879

NCBI Gene ID: 503841

neXtProt AC: NX_Q8N104

UniProt: Q8N104
Chr Location

8p23.1

MGI Vertebrate Homology

Defb34 stringent orthology
2 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: DEFB106A, DEFB106B
Gene Tree

Defb34

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

3
Targeted

4
Genomic Mutations

1 involving Defb34
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

15 strains or lines available

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All GO Annotations

9
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas

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All Sequences

28
RefSeq

4
UniProt

1
CCDS

CCDS52497.1

Ensembl

ENSMUSG00000052554 (Evidence)
NCBI Gene

360211

			Length	Strain/Species	Flank
genomic	ENSMUSG00000052554	Ensembl Gene Model \| MGI Sequence Detail	2789	C57BL/6J	± kb
transcript	ENSMUST00000064475	Ensembl \| MGI Sequence Detail	246	Not Applicable
polypeptide	ENSMUSP00000064554	Ensembl \| MGI Sequence Detail	81	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000006809 beta-defensin 34

(term hierarchy)
InterPro Domains

IPR025933 Beta-defensin

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Microarray probesets 1

Summaries

All 19

Gene Ontology 4

Phenotypes 5
Earliest

J:93238 Zaballos A, et al., Identification on mouse chromosome 8 of new beta-defensin genes with regionally specific expression in the male reproductive organ. J Biol Chem. 2004 Apr 26;279(13):12421-6
Latest

J:332494 Dong X, et al., Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection. Immunity. 2022 Jul 15;55(9):1645-1662

TSS for Defb34:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr2506	Chr8:19173730-19173731 (+)	-37 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24