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Fbxo11 Gene Detail
Summary
  • Symbol
    Fbxo11
  • Name
    F-box protein 11
  • Synonyms
    GENA 104, Jf
  • Feature Type
    protein coding gene
  • IDs
    MGI:2147134
    NCBI Gene: 225055
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:88298287-88372719 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 57.87 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1687 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2147134
 protein coding gene Chr17:88298287-88373473 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024108
 protein coding gene Chr17:91443225-91524166 (-)
A/J MGP_AJ_G0024068
 protein coding gene Chr17:88495921-88572099 (-)
AKR/J MGP_AKRJ_G0024037
 protein coding gene Chr17:89969384-90046048 (-)
BALB/cJ MGP_BALBcJ_G0024069
 protein coding gene Chr17:88326585-88403705 (-)
C3H/HeJ MGP_C3HHeJ_G0023834
 protein coding gene Chr17:90873759-90950235 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024514
 protein coding gene Chr17:94617239-94704809 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021952
 protein coding gene Chr17:83568632-83649126 (-)
CAST/EiJ MGP_CASTEiJ_G0023313
 protein coding gene Chr17:91704129-91783051 (-)
CBA/J MGP_CBAJ_G0023807
 protein coding gene Chr17:98614083-98701491 (-)
DBA/2J MGP_DBA2J_G0023936
 protein coding gene Chr17:86894091-86968554 (-)
FVB/NJ MGP_FVBNJ_G0023902
 protein coding gene Chr17:86412025-86487149 (-)
LP/J MGP_LPJ_G0024020
 protein coding gene Chr17:92240255-92318559 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023930
 protein coding gene Chr17:98437331-98515199 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024559
 protein coding gene Chr17:90517956-90603435 (-)
PWK/PhJ MGP_PWKPhJ_G0023058
 protein coding gene Chr17:86568384-86645604 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022869
 protein coding gene Chr17:87259230-87287125 (-)
WSB/EiJ MGP_WSBEiJ_G0023379
 protein coding gene Chr17:91331464-91372660 (-)



Homology
more
  • Human Ortholog
    FBXO11, F-box protein 11
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FBXO11, F-box protein 11
  • Synonyms
    FBX11, IDDFBA, PRMT9, UBR6, UG063H01, VIT1
  • Links
    NCBI Gene ID: 80204
    neXtProt AC: NX_Q86XK2
    UniProt: Q86XK2

  • Chr Location
    2p16.3; chr2:47789316-47906498 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Fbxo11 mouse models; 2 with human FBXO11 associations

Human Disease Mouse Models
      
IDs
 View 3 models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    43 phenotypes from 4 alleles in 6 genetic backgrounds
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for ENU-induced mutations exhibit cleft palate, facial clefting, and perinatal lethality. Mice homozygous for a knock-out allele show neonatal lethality, thick epidermis, decreased hair follicle number, absent keratohyalin granules, and increased epidermal Snail protein levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    873
  • Tissues
    120
  • cDNA Data
    22
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000005371 Ensembl Gene Model | MGI Sequence Detail 74433 C57BL/6J ±  kb
    transcript ENSMUST00000005504 Ensembl | MGI Sequence Detail 4019 Not Applicable  
    polypeptide ENSMUSP00000005504 Ensembl | MGI Sequence Detail 930 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      Genomic 2
      cDNA 22

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1861993
    References
    more
    • Summaries
      All 69
      Developmental Gene Expression 11
      Diseases 2
      Gene Ontology 11
      Phenotypes 28
    • Earliest
      J:8500 Van der Bliek AM, et al., Overexpression and amplification of five genes in a multidrug-resistant Chinese hamster ovary cell line. Mol Cell Biol. 1986 May;6(5):1671-8
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory