Arrdc3 MGI Mouse Gene Detail - MGI:2145242 - arrestin domain containing 3

Symbol

Arrdc3
Name

arrestin domain containing 3
Synonyms

mKIAA1376

Feature Type

protein coding gene
IDs

MGI:2145242
NCBI Gene: 105171
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr13:81031508-81044161 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 41.95 cM
Mapping Data

1 experiment

SNPs within 2kb

284 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2145242	protein coding gene	Chr13:81031503-81044161 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020785	protein coding gene	Chr13:81614971-81627634 (+)
A/J	MGP_AJ_G0020741	protein coding gene	Chr13:78778195-78790846 (+)
AKR/J	MGP_AKRJ_G0020714	protein coding gene	Chr13:81113704-81126355 (+)
BALB/cJ	MGP_BALBcJ_G0020737	protein coding gene	Chr13:79305467-79318118 (+)
C3H/HeJ	MGP_C3HHeJ_G0020531	protein coding gene	Chr13:80811437-80824091 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021174	protein coding gene	Chr13:84267611-84280379 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018742	protein coding gene	Chr13:75294899-75307581 (+)
CAST/EiJ	MGP_CASTEiJ_G0020049	protein coding gene	Chr13:79937836-79950494 (+)
CBA/J	MGP_CBAJ_G0020490	protein coding gene	Chr13:87491086-87503740 (+)
DBA/2J	MGP_DBA2J_G0020615	protein coding gene	Chr13:78431365-78444279 (+)
FVB/NJ	MGP_FVBNJ_G0020595	protein coding gene	Chr13:77526778-77539429 (+)
LP/J	MGP_LPJ_G0020688	protein coding gene	Chr13:81832801-81845525 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020624	protein coding gene	Chr13:86355919-86369609 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021214	protein coding gene	Chr13:80497839-80510490 (+)
PWK/PhJ	MGP_PWKPhJ_G0019802	protein coding gene	Chr13:77330389-77343368 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019625	protein coding gene	Chr13:76742579-76821583 (+)
WSB/EiJ	MGP_WSBEiJ_G0020106	protein coding gene	Chr13:80954464-80967156 (+)

Human Ortholog

ARRDC3, arrestin domain containing 3

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ARRDC3, arrestin domain containing 3
Synonyms

TLIMP
Links

HGNC:29263

NCBI Gene ID: 57561

neXtProt AC: NX_Q96B67

UniProt: Q96B67
Chr Location

5q14.3; chr5:91368631-91383317 (-) GRCh38

MGI Vertebrate Homology

Arrdc3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ARRDC3
Gene Tree

Arrdc3

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Phenotype Summary

28 phenotypes from 2 alleles in 2 genetic backgrounds
1 images
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

21
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

17
Targeted

2
Genomic Mutations

1 involving Arrdc3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

36 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene trap allele exhibit resistance to age-related obesity, insulin resistance, and hepatic steatosis. Mice homozygous for a different gene trap allele exhibit resistance to obesity, embryonic lethality when dams are fed a standard chow and dandruff due to very thin skin.

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All GO Annotations

21
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

723
Tissues

11
cDNA Data

116
Literature Summary

3

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase arrdc3

ZFIN arrdc3a, arrdc3b

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All Sequences

57
RefSeq

10
UniProt

4
CCDS

CCDS36736.1

Ensembl

ENSMUSG00000074794 (Evidence)
NCBI Gene

105171

			Length	Strain/Species	Flank
genomic	105171	NCBI Gene Model \| MGI Sequence Detail	12654	C57BL/6J	± kb
transcript	NR_153410	RefSeq \| MGI Sequence Detail	4137	C57BL/6
polypeptide	Q7TPQ9	UniProt \| EBI \| MGI Sequence Detail	414	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000032649 arrestin domain-containing protein 3

(term hierarchy)
InterPro Domains

IPR011022 Arrestin C-terminal-like domain

IPR050357 Arrestin domain-containing protein

IPR014752 Arrestin-like, C-terminal

IPR011021 Arrestin-like, N-terminal

IPR014756 Immunoglobulin E-set

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All nucleic 117

cDNA 117

Microarray probesets 3

Summaries

All 46

Developmental Gene Expression 3

Gene Ontology 7

Phenotypes 16
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:345061 La Marca JE, et al., Genome-wide CRISPR screening identifies a role for ARRDC3 in TRP53-mediated responses. Cell Death Differ. 2024 Feb;31(2):150-158

TSS for Arrdc3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr4125	Chr13:81031477-81031495 (+)	-22 bp
Tssr4126	Chr13:81031498-81031505 (+)	-6 bp
Tssr120467	Chr13:81031514-81031517 (+)	8 bp
Tssr120468	Chr13:81031522-81031541 (+)	24 bp
Tssr4127	Chr13:81031659-81031669 (+)	156 bp
Tssr4128	Chr13:81033039-81033071 (+)	1,547 bp
Tssr120469	Chr13:81033784-81033799 (+)	2,284 bp
Tssr120470	Chr13:81033804-81033830 (+)	2,309 bp
Tssr120471	Chr13:81033864-81033884 (+)	2,366 bp
Tssr120472	Chr13:81034279-81034320 (+)	2,792 bp
Tssr120473	Chr13:81034340-81034370 (+)	2,847 bp
Tssr120474	Chr13:81034407-81034431 (+)	2,911 bp
Tssr120475	Chr13:81034610-81034623 (+)	3,109 bp
Tssr120476	Chr13:81041916-81041926 (+)	10,413 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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