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Zic5 Gene Detail
Summary
  • Symbol
    Zic5
  • Name
    zinc finger protein of the cerebellum 5
  • Synonyms
    1700049L20Rik, odd-paired related, Opr
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929518
    NCBI Gene: 65100
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:122696572-122703127 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 65.96 cM, cytoband E5
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    115 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929518
 protein coding gene Chr14:122694207-122703127 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021671
 protein coding gene Chr14:120371455-120380583 (-)
A/J MGP_AJ_G0021631
 protein coding gene Chr14:115694528-115704767 (-)
AKR/J MGP_AKRJ_G0021607
 protein coding gene Chr14:119439486-119447990 (-)
BALB/cJ MGP_BALBcJ_G0021637
 protein coding gene Chr14:116244652-116253532 (-)
C3H/HeJ MGP_C3HHeJ_G0018086
 protein coding gene Chr11:55642829-55650539 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022077
 protein coding gene Chr14:124987312-124996518 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019615
 protein coding gene Chr14:111556197-111565002 (-)
CAST/EiJ MGP_CASTEiJ_G0020930
 protein coding gene Chr14:117247639-117256576 (-)
CBA/J MGP_CBAJ_G0021383
 protein coding gene Chr14:129737113-129745995 (-)
DBA/2J MGP_DBA2J_G0021506
 protein coding gene Chr14:115552931-115561811 (-)
FVB/NJ MGP_FVBNJ_G0021484
 protein coding gene Chr14:113906241-113916181 (-)
LP/J MGP_LPJ_G0021574
 protein coding gene Chr14:121280058-121291772 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021511
 protein coding gene Chr14:134719991-134730097 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022100
 protein coding gene Chr14:119033811-119042713 (-)
PWK/PhJ MGP_PWKPhJ_G0020674
 protein coding gene Chr14:112616001-112624946 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020512
 protein coding gene Chr14:115205604-115218714 (-)
WSB/EiJ MGP_WSBEiJ_G0020986
 protein coding gene Chr14:119700855-119709714 (-)



Homology
more
  • Human Ortholog
    ZIC5, Zic family member 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZIC5, Zic family member 5
  • Links
    NCBI Gene ID: 85416
    neXtProt AC: NX_Q96T25
    UniProt: Q96T25

  • Chr Location
    13q32.3; chr13:99962964-99971909 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    37 phenotypes from 2 alleles in 2 genetic backgrounds
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display postnatal lethality and reduced life spans with exencephaly, abnormal cerebral cortex and diencephalon morphology, abnormal gait and posture, and impaired growth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    875
  • Tissues
    127
  • cDNA Data
    6
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 65100 NCBI Gene Model | MGI Sequence Detail 6556 C57BL/6J ±  kb
    transcript NM_022987 RefSeq | MGI Sequence Detail 2383 C57BL/6  
    polypeptide Q7TQ40 UniProt | EBI | MGI Sequence Detail 622 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 6
      Primer pair 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1920601
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 17
      Gene Ontology 8
      Phenotypes 5
    • Earliest
      J:65637 Furushima K, et al., A new murine zinc finger gene, Opr. Mech Dev. 2000 Nov;98(1-2):161-4
    • Latest
      J:342617 Dali O, et al., Transgenerational epigenetic effects imposed by neonicotinoid thiacloprid exposure. Life Sci Alliance. 2024 Feb;7(2)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory