Tppp MGI Mouse Gene Detail - MGI:1920198 - tubulin polymerization promoting protein

Symbol

Tppp
Name

tubulin polymerization promoting protein
Synonyms

2900041A09Rik

Feature Type

protein coding gene
IDs

MGI:1920198
NCBI Gene: 72948
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr13:74157538-74183872 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 40.15 cM
Mapping Data

2 experiments

SNPs within 2kb

703 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920198	protein coding gene	Chr13:74157526-74183872 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020757	protein coding gene	Chr13:74501841-74528163 (+)
A/J	MGP_AJ_G0020713	protein coding gene	Chr13:71835311-71861636 (+)
AKR/J	MGP_AKRJ_G0020687	protein coding gene	Chr13:74085362-74113690 (+)
BALB/cJ	MGP_BALBcJ_G0020710	protein coding gene	Chr13:72330694-72357022 (+)
C3H/HeJ	MGP_C3HHeJ_G0020504	protein coding gene	Chr13:73772243-73801045 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021147	protein coding gene	Chr13:76977791-77004113 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018714	protein coding gene	Chr13:68657249-68684861 (+)
CAST/EiJ	MGP_CASTEiJ_G0020021	protein coding gene	Chr13:72847578-72875885 (+)
CBA/J	MGP_CBAJ_G0020463	protein coding gene	Chr13:79835088-79861425 (+)
DBA/2J	MGP_DBA2J_G0020588	protein coding gene	Chr13:71654427-71680734 (+)
FVB/NJ	MGP_FVBNJ_G0020568	protein coding gene	Chr13:70679897-70706231 (+)
LP/J	MGP_LPJ_G0020661	protein coding gene	Chr13:74738408-74764730 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020596	protein coding gene	Chr13:78244103-78270409 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021186	protein coding gene	Chr13:73409836-73436170 (+)
PWK/PhJ	MGP_PWKPhJ_G0019775	protein coding gene	Chr13:70393596-70420649 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019598	protein coding gene	Chr13:69880073-69912746 (+)
WSB/EiJ	MGP_WSBEiJ_G0020079	protein coding gene	Chr13:73960518-73988220 (+)

Human Ortholog

TPPP, tubulin polymerization promoting protein

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TPPP, tubulin polymerization promoting protein
Synonyms

p24, p25, p25alpha, TPPP1, TPPP/p25
Links

HGNC:24164

NCBI Gene ID: 11076

neXtProt AC: NX_O94811

UniProt: O94811
Chr Location

5p15.33; chr5:659862-700727 (-) GRCh38

MGI Vertebrate Homology

Tppp stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: TPPP
Gene Tree

Tppp

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Phenotype Summary

13 phenotypes from 1 allele in 1 genetic background
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

1
Targeted

5
Genomic Mutations

1 involving Tppp
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

64
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

841
Tissues

46
cDNA Data

35
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

36
RefSeq

4
UniProt

2
CCDS

CCDS26638.1

Ensembl

ENSMUSG00000021573 (Evidence)
NCBI Gene

72948

			Length	Strain/Species	Flank
genomic	72948	NCBI Gene Model \| MGI Sequence Detail	26335	C57BL/6J	± kb
transcript	NM_182839	RefSeq \| MGI Sequence Detail	5108	C57BL/6
polypeptide	Q7TQD2	UniProt \| EBI \| MGI Sequence Detail	218	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000016587 tubulin polymerization-promoting protein

(term hierarchy)
EC

3.6.5.-
InterPro Domains

IPR011992 EF-hand domain pair

IPR008907 Tubulin polymerization-promoting protein
GlyGen

Q7TQD2 4 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (3 sites)

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All nucleic 35

cDNA 35

Microarray probesets 4

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MGI:2145302

Summaries

All 48

Developmental Gene Expression 3

Gene Ontology 10

Phenotypes 15
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tppp:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr120345	Chr13:74157549-74157572 (+)	23 bp
Tssr120346	Chr13:74157579-74157602 (+)	53 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/22/2024 MGI 6.24