Gpr135 MGI Mouse Gene Detail - MGI:2676315 - G protein-coupled receptor 135

Symbol

Gpr135
Name

G protein-coupled receptor 135

Feature Type

protein coding gene
IDs

MGI:2676315
NCBI Gene: 238252
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr12:72114748-72117875 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 30.20 cM
Mapping Data

1 experiment

SNPs within 2kb

223 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2676315	protein coding gene	Chr12:72114748-72117899 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019820	protein coding gene	Chr12:71881378-71882751 (-)
A/J	MGP_AJ_G0019778	protein coding gene	Chr12:69207701-69209074 (-)
AKR/J	MGP_AKRJ_G0019754	protein coding gene	Chr12:71287577-71288950 (-)
BALB/cJ	MGP_BALBcJ_G0019758	protein coding gene	Chr12:69685365-69686738 (-)
C3H/HeJ	MGP_C3HHeJ_G0019563	protein coding gene	Chr12:71749239-71750612 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020210	protein coding gene	Chr12:74153096-74154469 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017830	protein coding gene	Chr12:66693552-66694925 (-)
CAST/EiJ	MGP_CASTEiJ_G0019115	protein coding gene	Chr12:66499254-66500627 (-)
CBA/J	MGP_CBAJ_G0019533	protein coding gene	Chr12:76903187-76904560 (-)
DBA/2J	MGP_DBA2J_G0019649	protein coding gene	Chr12:69114126-69115499 (-)
FVB/NJ	MGP_FVBNJ_G0019636	protein coding gene	Chr12:67984790-67986163 (-)
LP/J	MGP_LPJ_G0019721	protein coding gene	Chr12:71885758-71887131 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019675	protein coding gene	Chr12:80095647-80097020 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020245	protein coding gene	Chr12:70784802-70786175 (-)
PWK/PhJ	MGP_PWKPhJ_G0018880	protein coding gene	Chr12:63407130-63408503 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018675	protein coding gene	Chr12:65195595-65196968 (-)
WSB/EiJ	MGP_WSBEiJ_G0019166	protein coding gene	Chr12:71387810-71389183 (-)

Human Ortholog

GPR135, G protein-coupled receptor 135

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GPR135, G protein-coupled receptor 135
Synonyms

HUMNPIIY20
Links

HGNC:19991

NCBI Gene ID: 64582

neXtProt AC: NX_Q8IZ08

UniProt: Q8IZ08
Chr Location

14q23.1; chr14:59429022-59465380 (-) GRCh38

MGI Vertebrate Homology

Gpr135 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: GPR135
Gene Tree

Gpr135

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Endonuclease-mediated

4
Genomic Mutations

1 involving Gpr135
Incidental Mutations

APF
Find Mice (IMSR)

13 strains or lines available

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All GO Annotations

10
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

11

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gpr135

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All Sequences

38
RefSeq

2
UniProt

3
CCDS

CCDS25965.1

Ensembl

ENSMUSG00000043398 (Evidence)
NCBI Gene

238252

			Length	Strain/Species	Flank
genomic	238252	NCBI Gene Model \| MGI Sequence Detail	3128	C57BL/6J	± kb
transcript	NM_181752	RefSeq \| MGI Sequence Detail	3128	C57BL/6
polypeptide	Q7TQP2	UniProt \| EBI \| MGI Sequence Detail	457	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000001505 G-protein coupled receptor 135

(term hierarchy)
InterPro Domains

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like
GlyGen

Q7TQP2 1 site

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All nucleic 11

cDNA 11

Microarray probesets 3

Summaries

All 27

Gene Ontology 5

Phenotypes 7
Earliest

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Gpr135:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr116583	Chr12:72117867-72117880 (-)	1 bp
Tssr116582	Chr12:72117841-72117853 (-)	28 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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