Tnfsf18 MGI Mouse Gene Detail - MGI:2673064 - tumor necrosis factor (ligand) superfamily, member 18

Symbol

Tnfsf18
Name

tumor necrosis factor (ligand) superfamily, member 18
Synonyms

Gitrl, GITR ligand

Feature Type

protein coding gene
IDs

MGI:2673064
NCBI Gene: 240873
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr1:161322224-161332859 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 69.75 cM
Mapping Data

1 experiment

SNPs within 2kb

299 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2673064	protein coding gene	Chr1:161322221-161333903 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016653	protein coding gene	Chr1:166777188-166789331 (+)
A/J	MGP_AJ_G0016634	protein coding gene	Chr1:159996316-160006936 (+)
AKR/J	MGP_AKRJ_G0016600	protein coding gene	Chr1:164858669-164869295 (+)
BALB/cJ	MGP_BALBcJ_G0016595	protein coding gene	Chr1:160541843-160552473 (+)
C3H/HeJ	MGP_C3HHeJ_G0016419	protein coding gene	Chr1:165076022-165086654 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017056	protein coding gene	Chr1:172423416-172434051 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014765	protein coding gene	Chr1:152102252-152113471 (+)
CAST/EiJ	MGP_CASTEiJ_G0015999	protein coding gene	Chr1:164694994-164705600 (+)
CBA/J	MGP_CBAJ_G0016394	protein coding gene	Chr1:178549018-178559652 (+)
DBA/2J	MGP_DBA2J_G0016500	protein coding gene	Chr1:158966946-158977384 (+)
FVB/NJ	MGP_FVBNJ_G0016498	protein coding gene	Chr1:157371504-157382143 (+)
LP/J	MGP_LPJ_G0016571	protein coding gene	Chr1:167878453-167889087 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016523	protein coding gene	Chr1:186080428-186094578 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017092	protein coding gene	Chr1:164682378-164693012 (+)
PWK/PhJ	MGP_PWKPhJ_G0015785	protein coding gene	Chr1:158132629-158143305 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015572	protein coding gene	Chr1:163576655-163587295 (+)
WSB/EiJ	MGP_WSBEiJ_G0016061	protein coding gene	Chr1:164873606-164884228 (+)

Human Ortholog

TNFSF18, TNF superfamily member 18

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TNFSF18, TNF superfamily member 18
Synonyms

AITRL, GITRL, hGITRL, TL6, TNLG2A
Links

HGNC:11932

NCBI Gene ID: 8995

neXtProt AC: NX_Q9UNG2

UniProt: Q9UNG2
Chr Location

1q25.1; chr1:173039202-173050941 (-) GRCh38

MGI Vertebrate Homology

Tnfsf18 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TNFSF18
Gene Tree

Tnfsf18

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Phenotype Summary

9 phenotypes from 2 alleles in 2 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

2
Endonuclease-mediated

4
Targeted

7
Genomic Mutations

2 involving Tnfsf18
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Liver progenitor cell-specific conditional knock-out mice show attenuated ductular reaction, liver inflammation and liver fibrosis upon liver injury induced by feeding a choline-deficient diet supplemented with ethionine.

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All GO Annotations

37
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

709
Tissues

3
cDNA Data

4
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN tnfsf18

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All Sequences

36
RefSeq

2
UniProt

2
CCDS

CCDS15417.1

Ensembl

ENSMUSG00000066755 (Evidence)
NCBI Gene

240873

			Length	Strain/Species	Flank
genomic	ENSMUSG00000066755	Ensembl Gene Model \| MGI Sequence Detail	10636	C57BL/6J	± kb
transcript	ENSMUST00000086084	Ensembl \| MGI Sequence Detail	2066	Not Applicable
polypeptide	ENSMUSP00000083251	Ensembl \| MGI Sequence Detail	173	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000016488 tumor necrosis factor ligand superfamily member 18

(term hierarchy)
PDB

2Q8O, 2QDN, 3B9I, 3FC0, 7E57, 7KHX
InterPro Domains

IPR042380 Tumor necrosis factor ligand superfamily member 18

IPR006052 Tumour necrosis factor domain

IPR008983 Tumour necrosis factor-like domain superfamily
GlyGen

Q7TS55 1 site

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All nucleic 4

cDNA 4

Microarray probesets 1

Summaries

All 55

Developmental Gene Expression 1

Gene Ontology 12

Phenotypes 16
Earliest

J:86980 Tone M, et al., Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells. Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15059-64
Latest

J:346395 Li L, et al., GITRL impairs hepatocyte repopulation by liver progenitor cells to aggravate inflammation and fibrosis by GITR(+)CD8(+) T lymphocytes in CDE Mice. Cell Death Dis. 2024 Feb 6;15(2):114

TSS for Tnfsf18:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr9690	Chr1:161322218-161322225 (+)	-2 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24