Tmem94 MGI Mouse Gene Detail - MGI:1919197

Symbol

Tmem94
Name

transmembrane protein 94
Synonyms

2310067B10Rik, mKIAA0195

Feature Type

protein coding gene
IDs

MGI:1919197
NCBI Gene: 71947
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr11:115656245-115689859 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 80.91 cM, cytoband E2
Mapping Data

2 experiments

SNPs within 2kb

931 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919197	protein coding gene	Chr11:115656245-115690192 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019399	protein coding gene	Chr11:119829140-119866033 (+)
A/J	MGP_AJ_G0019368	protein coding gene	Chr11:114591032-114623241 (+)
AKR/J	MGP_AKRJ_G0019338	protein coding gene	Chr11:118010124-118044782 (+)
BALB/cJ	MGP_BALBcJ_G0019342	protein coding gene	Chr11:115007657-115040726 (+)
C3H/HeJ	MGP_C3HHeJ_G0019148	protein coding gene	Chr11:118361471-118393943 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019792	protein coding gene	Chr11:123486699-123528827 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017415	protein coding gene	Chr11:111610605-111646484 (+)
CAST/EiJ	MGP_CASTEiJ_G0018703	protein coding gene	Chr11:119694270-119733452 (+)
CBA/J	MGP_CBAJ_G0019120	protein coding gene	Chr11:128384587-128418159 (+)
DBA/2J	MGP_DBA2J_G0019231	protein coding gene	Chr11:114014806-114049448 (+)
FVB/NJ	MGP_FVBNJ_G0019223	protein coding gene	Chr11:113509152-113549750 (+)
LP/J	MGP_LPJ_G0019301	protein coding gene	Chr11:120215492-120247897 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019256	protein coding gene	Chr11:127494536-127530242 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019830	protein coding gene	Chr11:118660328-118696527 (+)
PWK/PhJ	MGP_PWKPhJ_G0018467	protein coding gene	Chr11:115324749-115360281 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018260	protein coding gene	Chr11:118408796-118444397 (+)
WSB/EiJ	MGP_WSBEiJ_G0018755	protein coding gene	Chr11:118624478-118658886 (+)

Human Ortholog

TMEM94, transmembrane protein 94

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TMEM94, transmembrane protein 94
Synonyms

ERMA, IDDCDF, KIAA0195
Links

HGNC:28983

NCBI Gene ID: 9772

neXtProt AC: NX_Q12767

UniProt: Q12767
Chr Location

17q25.1; chr17:75441159-75500452 (+) GRCh38

MGI Vertebrate Homology

Tmem94 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TMEM94
Gene Tree

Tmem94

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Phenotype Summary

20 phenotypes from 2 alleles in 2 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Endonuclease-mediated

3
Gene trapped

14
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

70 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice show lethality by P1, growth retardation, craniofacial and cardiac abnormalities, and abnormal neuronal migration pattern.

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All GO Annotations

12
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

724
Tissues

12
cDNA Data

11
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tmem94

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All Sequences

89
RefSeq

34
UniProt

9
CCDS

CCDS25646.1

Ensembl

ENSMUSG00000020747 (Evidence)
NCBI Gene

71947

			Length	Strain/Species	Flank
genomic	71947	NCBI Gene Model \| MGI Sequence Detail	33615	C57BL/6J	± kb
transcript	NM_028014	RefSeq \| MGI Sequence Detail	4996	C57BL/6
polypeptide	Q7TSH8	UniProt \| EBI \| MGI Sequence Detail	1360	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000059778 transmembrane protein 94

(term hierarchy)
InterPro Domains

IPR023298 P-type ATPase, transmembrane domain superfamily

IPR039720 Transmembrane protein 94
GlyGen

Q7TSH8 7 sites, 2 N-linked glycans (2 sites)

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All nucleic 12

cDNA 12

Microarray probesets 2

Summaries

All 33

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 12
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:347153 Vishnu N, et al., ERMA (TMEM94) is a P-type ATPase transporter for Mg(2+) uptake in the endoplasmic reticulum. Mol Cell. 2024 Apr 4;84(7):1321-1337.e11

TSS for Tmem94:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr105895	Chr11:115656246-115656292 (+)	24 bp
Tssr105896	Chr11:115656326-115656359 (+)	98 bp
Tssr105897	Chr11:115657502-115657564 (+)	1,288 bp
Tssr105898	Chr11:115657606-115657622 (+)	1,369 bp
Tssr105899	Chr11:115657627-115657647 (+)	1,392 bp
Tssr105900	Chr11:115667062-115667103 (+)	10,838 bp
Tssr105901	Chr11:115671486-115671514 (+)	15,255 bp
Tssr105902	Chr11:115671524-115671544 (+)	15,289 bp
Tssr105903	Chr11:115671563-115671582 (+)	15,328 bp
Tssr105904	Chr11:115671591-115671612 (+)	15,357 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24